Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus Export

@article{citeulike:2260795, abstract = {10.1073/pnas.0705273104 It is well established that the medial-temporal lobe (MTL) is critical for recognition memory. The MTL is known to be composed of distinct structures that are organized in a hierarchical manner. At present, it remains controversial whether lower structures in this hierarchy, such as perirhinal cortex, support memory functions that are distinct from those of higher structures, in particular the hippocampus. Perirhinal cortex has been proposed to play a specific role in the assessment of familiarity during recognition, which can be distinguished from the selective contributions of the hippocampus to the recollection of episodic detail. Some researchers have argued, however, that the distinction between familiarity and recollection cannot capture functional specialization within the MTL and have proposed single-process accounts. Evidence supporting the dual-process view comes from demonstrations that selective hippocampal damage can produce isolated recollection impairments. It is unclear, however, whether temporal-lobe lesions that spare the hippocampus can produce selective familiarity impairments. Without this demonstration, single-process accounts cannot be ruled out. We examined recognition memory in NB, an individual who underwent surgical resection of left anterior temporal-lobe structures for treatment of intractable epilepsy. Her resection included a large portion of perirhinal cortex but spared the hippocampus. The results of four experiments based on three different experimental procedures (remember-know paradigm, receiver operating characteristics, and response-deadline procedure) indicate that NB exhibits impaired familiarity with preserved recollection. The present findings thus provide a crucial missing piece of support for functional specialization in the MTL.}, author = {Bowles, Ben and Crupi, Carina and Mirsattari, Seyed M. and Pigott, Susan E. and Parrent, Andrew G. and Pruessner, Jens C. and Yonelinas, Andrew P. and K\~{A}{\P}hler, Stefan}, citeulike-article-id = {2260795}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0705273104}, citeulike-linkout-1 = {http://www.pnas.org/content/104/41/16382.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/104/41/16382.full.pdf}, citeulike-linkout-3 = {http://www.pnas.org/cgi/content/abstract/104/41/16382}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17905870}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17905870}, day = {9}, doi = {10.1073/pnas.0705273104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {familiarity, hippocampus, memory, mtl, novelty, prh, recognition\_memory, recollection}, month = {October}, number = {41}, pages = {16382--16387}, posted-at = {2009-11-08 21:21:53}, priority = {4}, title = {Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus}, url = {http://dx.doi.org/10.1073/pnas.0705273104}, volume = {104}, year = {2007} }

TY - JOUR ID - citeulike:2260795 L3 - citeulike-article-id:2260795 N2 - 10.1073/pnas.0705273104 It is well established that the medial-temporal lobe (MTL) is critical for recognition memory. The MTL is known to be composed of distinct structures that are organized in a hierarchical manner. At present, it remains controversial whether lower structures in this hierarchy, such as perirhinal cortex, support memory functions that are distinct from those of higher structures, in particular the hippocampus. Perirhinal cortex has been proposed to play a specific role in the assessment of familiarity during recognition, which can be distinguished from the selective contributions of the hippocampus to the recollection of episodic detail. Some researchers have argued, however, that the distinction between familiarity and recollection cannot capture functional specialization within the MTL and have proposed single-process accounts. Evidence supporting the dual-process view comes from demonstrations that selective hippocampal damage can produce isolated recollection impairments. It is unclear, however, whether temporal-lobe lesions that spare the hippocampus can produce selective familiarity impairments. Without this demonstration, single-process accounts cannot be ruled out. We examined recognition memory in NB, an individual who underwent surgical resection of left anterior temporal-lobe structures for treatment of intractable epilepsy. Her resection included a large portion of perirhinal cortex but spared the hippocampus. The results of four experiments based on three different experimental procedures (remember-know paradigm, receiver operating characteristics, and response-deadline procedure) indicate that NB exhibits impaired familiarity with preserved recollection. The present findings thus provide a crucial missing piece of support for functional specialization in the MTL. IS - 41 JF - Proceedings of the National Academy of Sciences EP - 16387 TI - Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus VL - 104 SP - 16382 KW - familiarity KW - hippocampus KW - memory KW - mtl KW - novelty KW - prh KW - recognition_memory KW - recollection AU - Bowles, Ben AU - Crupi, Carina AU - Mirsattari, Seyed AU - Pigott, Susan AU - Parrent, Andrew AU - Pruessner, Jens AU - Yonelinas, Andrew AU - Köhler, Stefan PY - 2007/10/09/ UR - http://dx.doi.org/10.1073/pnas.0705273104 ER -