Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells Export

@article{citeulike:3372688, abstract = {Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ERbeta2, ERbeta5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine.}, author = {Treeck, O. and Lattrich, C. and Juhasz-Boess, I. and Buchholz, S. and Pfeiler, G. and Ortmann, O.}, citeulike-article-id = {3372688}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.bjc.6604692}, comment = {In the latest issue of JAMA, a study links a SNP variant of the adiponectin gene and the risk for developing colorectal cancer.}, day = {30}, doi = {10.1038/sj.bjc.6604692}, journal = {British Journal of Cancer}, keywords = {adiponectin, adipose, breast, cancer, cytokine, immunology, mcf-7}, month = {September}, posted-at = {2008-10-04 08:18:30}, priority = {2}, publisher = {Cancer Research UK}, title = {Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells}, url = {http://dx.doi.org/10.1038/sj.bjc.6604692}, year = {2008} }

TY - JOUR ID - citeulike:3372688 L3 - citeulike-article-id:3372688 N2 - Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ERbeta2, ERbeta5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine. JF - British Journal of Cancer TI - Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells PB - Cancer Research UK KW - adiponectin KW - adipose KW - breast KW - cancer KW - cytokine KW - immunology KW - mcf-7 N1 - In the latest issue of JAMA, a study links a SNP variant of the adiponectin gene and the risk for developing colorectal cancer. AU - Treeck, O AU - Lattrich, C AU - Juhasz-Boess, I AU - Buchholz, S AU - Pfeiler, G AU - Ortmann, O PY - 2008/09/30/online UR - http://dx.doi.org/10.1038/sj.bjc.6604692 ER -