Androgens and androgen receptors in breast cancer Export

@article{citeulike:3498635, abstract = {Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are displacing antiestrogens as the first-line treatment for estrogen receptor positive breast cancers. Androgens can act as estrogen precursors, but besides this capability they can also directly act on breast cancer cells by binding to androgen receptors, which are present in the majority of breast cancer specimens. Epidemiological and clinical evidences suggest that higher levels of circulating androgen increase the risk of developing breast cancer. Androgen receptor gene polymorphisms which render the more transcriptionally active receptors have been related to a lower risk of breast cancer. It is currently accepted that androgens act as antiproliferative agents in the presence of estrogens in some breast cancer cell lines. However, emerging evidence suggests that direct androgenic activity might also stimulate cell growth in a subset of estrogen-resistant breast tumors. Here we discuss the supporting evidence which proposes that androgens themselves are actively involved in breast carcinogenesis and its clinical behaviour.}, author = {Nicolasdiazchico, B. and Germanrodriguez, F. and Gonzalez, A. and Ramirez, R. and Bilbao, C. and Cabreradeleon, A. and Aguirrejaime, A. and Chirino, R. and Navarro, D. and Diazchico, J.}, citeulike-article-id = {3498635}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jsbmb.2006.11.019}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0960076007000982}, doi = {10.1016/j.jsbmb.2006.11.019}, issn = {09600760}, journal = {The Journal of Steroid Biochemistry and Molecular Biology}, keywords = {androgen, aromatase, breast, cancer, estrogen, hormone, measurement, receptor}, month = {June}, number = {1-5}, pages = {1--15}, posted-at = {2008-11-09 18:23:12}, priority = {2}, title = {Androgens and androgen receptors in breast cancer}, url = {http://dx.doi.org/10.1016/j.jsbmb.2006.11.019}, volume = {105}, year = {2007} }

TY - JOUR ID - citeulike:3498635 L3 - citeulike-article-id:3498635 N2 - Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are displacing antiestrogens as the first-line treatment for estrogen receptor positive breast cancers. Androgens can act as estrogen precursors, but besides this capability they can also directly act on breast cancer cells by binding to androgen receptors, which are present in the majority of breast cancer specimens. Epidemiological and clinical evidences suggest that higher levels of circulating androgen increase the risk of developing breast cancer. Androgen receptor gene polymorphisms which render the more transcriptionally active receptors have been related to a lower risk of breast cancer. It is currently accepted that androgens act as antiproliferative agents in the presence of estrogens in some breast cancer cell lines. However, emerging evidence suggests that direct androgenic activity might also stimulate cell growth in a subset of estrogen-resistant breast tumors. Here we discuss the supporting evidence which proposes that androgens themselves are actively involved in breast carcinogenesis and its clinical behaviour. IS - 1-5 JF - The Journal of Steroid Biochemistry and Molecular Biology SN - 09600760 EP - 15 TI - Androgens and androgen receptors in breast cancer VL - 105 SP - 1 KW - androgen KW - aromatase KW - breast KW - cancer KW - estrogen KW - hormone KW - measurement KW - receptor AU - Nicolasdiazchico, B AU - Germanrodriguez, F AU - Gonzalez, A AU - Ramirez, R AU - Bilbao, C AU - Cabreradeleon, A AU - Aguirrejaime, A AU - Chirino, R AU - Navarro, D AU - Diazchico, J PY - 2007/06// UR - http://dx.doi.org/10.1016/j.jsbmb.2006.11.019 ER -