Bad seeds produce bad crops: A single stage-process of breast carcinogenesis☆☆☆ Export

@article{citeulike:3726753, abstract = {Loss of the myoepithelial (ME) cell layer is the most distinct sign associated with invasion. Our recent studies revealed that a subset of normal appearing duct clusters harbored a high frequency of focal ME cell layer disruptions (FMCLD). The residual ME cells of these duct clusters had significantly reduced expression of tumor suppressors, elevated rates of apoptosis and infiltration of immunoreactive cells, and the epithelial cell clusters overlying these disruptions had a significantly elevated frequency of tumor-associated phenotypes. Based on these and other findings, we have proposed that these morphologically normal appearing duct clusters are derived from genetically damaged stem cells, and could progress directly to invasion or metastasis through two pathways: (1) the entire ME basal cell layer is gradually degenerated or disappeared, allowing direct physical contact of epithelial cells with stromal and immunoreactive cells, which induce invasive properties without morphological alterations and (2) ER negative cell clusters overlying FMCLD retain the potential for multi-lineage differentiation that continuously proliferate and provide new cells and their own vascular structures for invasion and metastasis.}, author = {Man, Y.}, citeulike-article-id = {3726753}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bihy.2008.04.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1756239208000396}, doi = {10.1016/j.bihy.2008.04.002}, issn = {17562392}, journal = {Bioscience Hypotheses}, keywords = {alternative, breast, cancer, carcinogenesis, hypothesis, review}, number = {3}, pages = {147--155}, posted-at = {2008-11-29 10:03:02}, priority = {2}, title = {Bad seeds produce bad crops: A single stage-process of breast carcinogenesis☆☆☆}, url = {http://dx.doi.org/10.1016/j.bihy.2008.04.002}, volume = {1}, year = {2008} }

TY - JOUR ID - citeulike:3726753 L3 - citeulike-article-id:3726753 N2 - Loss of the myoepithelial (ME) cell layer is the most distinct sign associated with invasion. Our recent studies revealed that a subset of normal appearing duct clusters harbored a high frequency of focal ME cell layer disruptions (FMCLD). The residual ME cells of these duct clusters had significantly reduced expression of tumor suppressors, elevated rates of apoptosis and infiltration of immunoreactive cells, and the epithelial cell clusters overlying these disruptions had a significantly elevated frequency of tumor-associated phenotypes. Based on these and other findings, we have proposed that these morphologically normal appearing duct clusters are derived from genetically damaged stem cells, and could progress directly to invasion or metastasis through two pathways: (1) the entire ME basal cell layer is gradually degenerated or disappeared, allowing direct physical contact of epithelial cells with stromal and immunoreactive cells, which induce invasive properties without morphological alterations and (2) ER negative cell clusters overlying FMCLD retain the potential for multi-lineage differentiation that continuously proliferate and provide new cells and their own vascular structures for invasion and metastasis. IS - 3 JF - Bioscience Hypotheses SN - 17562392 EP - 155 TI - Bad seeds produce bad crops: A single stage-process of breast carcinogenesis☆☆☆ VL - 1 SP - 147 KW - alternative KW - breast KW - cancer KW - carcinogenesis KW - hypothesis KW - review AU - Man, Y PY - 2008/// UR - http://dx.doi.org/10.1016/j.bihy.2008.04.002 ER -