Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice. Export

@article{citeulike:4564934, abstract = {We report herein a study of aging using in vitro and in vivo models. Glial fibrillary acidic protein and ferritin expression levels increased, and the levels of glutamate transporter 1 and transferrin receptor 1 decreased in aging mouse spinal cord and its astrocytes. Mitochondrial transmembrane potential in astrocytes decreased after 60 d of culture. Given the relationship between aging and loss of antioxidant tolerance capacity, we examined the expression of heme oxygenase 1 (HO1) and NAD(P)H/quinone oxidoreductase 1 (NQO1) in the old mouse astrocytes and spinal cord. Indeed, both antioxidant enzymes decreased there. Total nuclear factor E2-related factor 2, which governs basal and inducible expression of HO1 and NQO1, decreased significantly. Significantly, epigallocatechin gallate restored the Nrf2 activity.}, author = {Duan, Weisong and Zhang, Ruiyan and Guo, Yansu and Jiang, Yifang and Huang, Yanli and Jiang, Hong and Li, Chunyan}, citeulike-article-id = {4564934}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s11626-009-9194-5}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19452231}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19452231}, day = {19}, doi = {10.1007/s11626-009-9194-5}, issn = {1543-706X}, journal = {In vitro cellular \& developmental biology. Animal}, keywords = {aging, astrocytes, nrf2, spinal\_cord}, month = {May}, number = {7}, pages = {388--397}, posted-at = {2009-05-20 23:22:13}, priority = {3}, title = {Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice.}, url = {http://dx.doi.org/10.1007/s11626-009-9194-5}, volume = {45}, year = {2009} }

TY - JOUR ID - citeulike:4564934 L3 - citeulike-article-id:4564934 N2 - We report herein a study of aging using in vitro and in vivo models. Glial fibrillary acidic protein and ferritin expression levels increased, and the levels of glutamate transporter 1 and transferrin receptor 1 decreased in aging mouse spinal cord and its astrocytes. Mitochondrial transmembrane potential in astrocytes decreased after 60 d of culture. Given the relationship between aging and loss of antioxidant tolerance capacity, we examined the expression of heme oxygenase 1 (HO1) and NAD(P)H/quinone oxidoreductase 1 (NQO1) in the old mouse astrocytes and spinal cord. Indeed, both antioxidant enzymes decreased there. Total nuclear factor E2-related factor 2, which governs basal and inducible expression of HO1 and NQO1, decreased significantly. Significantly, epigallocatechin gallate restored the Nrf2 activity. IS - 7 JF - In vitro cellular & developmental biology. Animal SN - 1543-706X EP - 397 TI - Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice. VL - 45 SP - 388 KW - aging KW - astrocytes KW - nrf2 KW - spinal_cord AU - Duan, Weisong AU - Zhang, Ruiyan AU - Guo, Yansu AU - Jiang, Yifang AU - Huang, Yanli AU - Jiang, Hong AU - Li, Chunyan PY - 2009/05/19/g UR - http://dx.doi.org/10.1007/s11626-009-9194-5 ER -