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Suppression of serum adrenal cortex hormones by chronic low-dose polychiorobiphenyl or polybromobiphenyl treatments Export

Archives of Environmental Contamination and Toxicology, Vol. 17, No. 1. (1 January 1988), pp. 47-53.

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adrenal_cortex pbde pcb

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Studies evaluate serum adrenal cortical hormones during chronic intoxication with low levels of polychlorinated biphenyls (PCB) and polybrominated biphenyl (PBB). Serum levels of corticosterone (B) (the principal glucocorticoid in rats), dehydroepiandrosterone (DHEA) (an androgen), and dehydroepiandrosterone sulfate (DHS) were assessed at regular intervals over 5–7 months treatment in female Sprague-Dawley rats. Aroclors® 1254, 1242, 1016 or hexabromobiphenyl (Fire master BP-6®) were supplemented in the food at following concentrations: 0, 1, 5, 10 or 50 ppm wt/wt in the food.


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