Tracking the hemodynamic responses to reward and punishment in the striatum.

@article{citeulike:1240022, abstract = {Research suggests that the basal ganglia complex is a major component of the neural circuitry that mediates reward-related processing. However, human studies have not yet characterized the response of the basal ganglia to an isolated reward, as has been done in animals. We developed an event-related functional magnetic resonance imaging paradigm to identify brain areas that are activated after presentation of a reward. Subjects guessed whether the value of a card was higher or lower than the number 5, with monetary rewards as an incentive for correct guesses. They received reward, punishment, or neutral feedback on different trials. Regions in the dorsal and ventral striatum were activated by the paradigm, showing differential responses to reward and punishment. Activation was sustained following a reward feedback, but decreased below baseline following a punishment feedback.}, address = {Department of Neuroscience, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15260, USA. delgado@brain.bns.pitt.edu}, author = {Delgado, M. R. and Nystrom, L. E. and Fissell, C. and Noll, D. C. and Fiez, J. A. }, citeulike-article-id = {1240022}, issn = {0022-3077}, journal = {J Neurophysiol}, keywords = {caudate, fmri, hemodynamic\_response, punishment, reward, striatum}, month = {December}, number = {6}, pages = {3072--3077}, posted-at = {2007-04-20 17:35:25}, priority = {2}, title = {Tracking the hemodynamic responses to reward and punishment in the striatum.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11110834}, volume = {84}, year = {2000} }

TY - JOUR ID - citeulike:1240022 L3 - citeulike-article-id:1240022 TI - Tracking the hemodynamic responses to reward and punishment in the striatum. JF - J Neurophysiol VL - 84 IS - 6 SP - 3072 EP - 3077 AD - Department of Neuroscience, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15260, USA. delgado@brain.bns.pitt.edu SN - 0022-3077 N2 - Research suggests that the basal ganglia complex is a major component of the neural circuitry that mediates reward-related processing. However, human studies have not yet characterized the response of the basal ganglia to an isolated reward, as has been done in animals. We developed an event-related functional magnetic resonance imaging paradigm to identify brain areas that are activated after presentation of a reward. Subjects guessed whether the value of a card was higher or lower than the number 5, with monetary rewards as an incentive for correct guesses. They received reward, punishment, or neutral feedback on different trials. Regions in the dorsal and ventral striatum were activated by the paradigm, showing differential responses to reward and punishment. Activation was sustained following a reward feedback, but decreased below baseline following a punishment feedback. KW - caudate KW - fmri KW - hemodynamic_response KW - punishment KW - reward KW - striatum AU - Delgado, MR AU - Nystrom, LE AU - Fissell, C AU - Noll, DC AU - Fiez, JA PY - 2000/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/11110834 ER -