Prefrontal phase locking to hippocampal theta oscillations.

@article{citeulike:335412, abstract = {The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hippocampal theta rhythm. In addition, we show that prefrontal neurons phase lock best to theta oscillations delayed by approximately 50 ms and confirm this hippocampo-prefrontal directionality and timing at the level of correlations between single cells. Finally, we find that phase locking of prefrontal cells is predicted by the presence of significant correlations with hippocampal cells at positive delays up to 150 ms. The theta-entrained activity across cortico-hippocampal circuits described here may be important for gating information flow and guiding the plastic changes that are believed to underlie the storage of information across these networks.}, address = {Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA. thanos@caltech.edu}, author = {Siapas, A. G. and Lubenov, E. V. and Wilson, M. A. }, citeulike-article-id = {335412}, doi = {10.1016/j.neuron.2005.02.028}, issn = {0896-6273}, journal = {Neuron}, keywords = {hippocampus, phaselocking, prefrontal, rat, theta}, month = {April}, number = {1}, pages = {141--151}, posted-at = {2005-09-29 19:34:07}, priority = {0}, title = {Prefrontal phase locking to hippocampal theta oscillations.}, url = {http://dx.doi.org/10.1016/j.neuron.2005.02.028}, volume = {46}, year = {2005} }

TY - JOUR ID - citeulike:335412 L3 - citeulike-article-id:335412 TI - Prefrontal phase locking to hippocampal theta oscillations. JF - Neuron VL - 46 IS - 1 SP - 141 EP - 151 AD - Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA. thanos@caltech.edu SN - 0896-6273 N2 - The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hippocampal theta rhythm. In addition, we show that prefrontal neurons phase lock best to theta oscillations delayed by approximately 50 ms and confirm this hippocampo-prefrontal directionality and timing at the level of correlations between single cells. Finally, we find that phase locking of prefrontal cells is predicted by the presence of significant correlations with hippocampal cells at positive delays up to 150 ms. The theta-entrained activity across cortico-hippocampal circuits described here may be important for gating information flow and guiding the plastic changes that are believed to underlie the storage of information across these networks. KW - hippocampus KW - phaselocking KW - prefrontal KW - rat KW - theta AU - Siapas, AG AU - Lubenov, EV AU - Wilson, MA PY - 2005/04/07/ UR - http://dx.doi.org/10.1016/j.neuron.2005.02.028 ER -