Pulmonary toxicity of endotoxins: comparison of lipopolysaccharides from various bacterial species. Export

@article{citeulike:3577904, abstract = {Lipopolysaccharides from three gram-negative bacteria isolated from bale cotton and piggery air were analyzed for their chemical composition, and their pulmonary toxicity for guinea pigs, lethal toxicity for mice, and pyrogenicity for rabbits were measured. Lipopolysaccharides from Enterobacter agglomerans and Citrobacter freundii had closely related chemical compositions; both were pyrogenic for rabbits and caused a dose-dependent influx of polymorphonuclear leukocytes into the airways of guinea pigs. The lethal toxicities of these lipopolysaccharides in mice were comparable to that of Salmonella typhimurium lipopolysaccharide, which was used as a reference. Lipopolysaccharide from Agrobacterium sp. was chemically different from those of E. agglomerans and C. freundii, did not induce any influx of polymorphonuclear leukocytes, and was only weakly toxic or pyrogenic. The low biological activity of the agrobacterial lipopolysaccharide may be due to its different chemical composition.}, author = {Helander, I. and Sax\'{e}n, H. and Salkinoja-Salonen, M. and Rylander, R.}, citeulike-article-id = {3577904}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7056574}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7056574}, issn = {0019-9567}, journal = {Infection and immunity}, keywords = {endotoxins, gram-negative\_bacteria, lipopolysaccharides}, month = {February}, number = {2}, pages = {528--532}, posted-at = {2008-11-19 11:43:33}, priority = {3}, title = {Pulmonary toxicity of endotoxins: comparison of lipopolysaccharides from various bacterial species.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7056574}, volume = {35}, year = {1982} }

TY - JOUR ID - citeulike:3577904 L3 - citeulike-article-id:3577904 N2 - Lipopolysaccharides from three gram-negative bacteria isolated from bale cotton and piggery air were analyzed for their chemical composition, and their pulmonary toxicity for guinea pigs, lethal toxicity for mice, and pyrogenicity for rabbits were measured. Lipopolysaccharides from Enterobacter agglomerans and Citrobacter freundii had closely related chemical compositions; both were pyrogenic for rabbits and caused a dose-dependent influx of polymorphonuclear leukocytes into the airways of guinea pigs. The lethal toxicities of these lipopolysaccharides in mice were comparable to that of Salmonella typhimurium lipopolysaccharide, which was used as a reference. Lipopolysaccharide from Agrobacterium sp. was chemically different from those of E. agglomerans and C. freundii, did not induce any influx of polymorphonuclear leukocytes, and was only weakly toxic or pyrogenic. The low biological activity of the agrobacterial lipopolysaccharide may be due to its different chemical composition. IS - 2 JF - Infection and immunity SN - 0019-9567 EP - 532 TI - Pulmonary toxicity of endotoxins: comparison of lipopolysaccharides from various bacterial species. VL - 35 SP - 528 KW - endotoxins KW - gram-negative_bacteria KW - lipopolysaccharides AU - Helander, I AU - Saxén, H AU - Salkinoja-Salonen, M AU - Rylander, R PY - 1982/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/7056574 ER -