Decreased Expression of Murine PPARgamma in Adipose Tissue during Endotoxemia Export

@article{citeulike:3042514, abstract = {Infection-induced hyperlipidemia develops due to a combination of factors, one of which is decreased clearance of lipids from the bloodstream due to depressed synthesis of lipoprotein lipase (LPL). Recently, the peroxisome proliferator activated receptors (PPARs) have been shown to be important in the regulation of LPL, particularly PPAR{gamma}. PPAR{gamma} and its heterodimerization partner, RXR{alpha} have been shown to be transcriptional activators of LPL in co-transfection analysis. Therefore, we hypothesized that the decrease in LPL expression during endotoxemia may be a result of depressed PPAR{gamma} expression. In these studies, we examined the effect of endotoxin or its proximal mediator, tumor necrosis factor (TNF), on the expression of PPAR{gamma} in white (WAT) and brown adipose tissue (BAT) in CD-1 mice. We report that treatment with endotoxin, but not TNF, transiently decreased PPAR{gamma} mRNA levels 4 hr after treatment. However, endotoxin or TNF treatment decreased PPAR{gamma} protein levels after 18 hr, which was at a time when LPL mRNA levels were also depressed. These data suggest that decreased PPAR{gamma} expression following endotoxin or TNF treatment may contribute to the hyperlipidemia due to decreased expression of LPL, which would impair triglyceride clearance. 10.1210/en.138.7.3073}, author = {Hill, Molly R. and Young, Misty D. and Mccurdy, Caren M. and Gimble, Jeffrey M.}, citeulike-article-id = {3042514}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/en.138.7.3073}, citeulike-linkout-1 = {http://endo.endojournals.org/cgi/content/abstract/138/7/3073}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/9202256}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=9202256}, day = {1}, doi = {10.1210/en.138.7.3073}, journal = {Endocrinology}, keywords = {adipose\_tissue, endotoxemia, ppar-gamma}, month = {July}, number = {7}, pages = {3073+}, posted-at = {2009-04-17 00:00:00}, priority = {3}, title = {Decreased Expression of Murine PPAR{gamma} in Adipose Tissue during Endotoxemia}, url = {http://dx.doi.org/10.1210/en.138.7.3073}, volume = {138}, year = {1997} }

TY - JOUR ID - citeulike:3042514 L3 - citeulike-article-id:3042514 N2 - Infection-induced hyperlipidemia develops due to a combination of factors, one of which is decreased clearance of lipids from the bloodstream due to depressed synthesis of lipoprotein lipase (LPL). Recently, the peroxisome proliferator activated receptors (PPARs) have been shown to be important in the regulation of LPL, particularly PPAR{gamma}. PPAR{gamma} and its heterodimerization partner, RXR{alpha} have been shown to be transcriptional activators of LPL in co-transfection analysis. Therefore, we hypothesized that the decrease in LPL expression during endotoxemia may be a result of depressed PPAR{gamma} expression. In these studies, we examined the effect of endotoxin or its proximal mediator, tumor necrosis factor (TNF), on the expression of PPAR{gamma} in white (WAT) and brown adipose tissue (BAT) in CD-1 mice. We report that treatment with endotoxin, but not TNF, transiently decreased PPAR{gamma} mRNA levels 4 hr after treatment. However, endotoxin or TNF treatment decreased PPAR{gamma} protein levels after 18 hr, which was at a time when LPL mRNA levels were also depressed. These data suggest that decreased PPAR{gamma} expression following endotoxin or TNF treatment may contribute to the hyperlipidemia due to decreased expression of LPL, which would impair triglyceride clearance. 10.1210/en.138.7.3073 IS - 7 JF - Endocrinology TI - Decreased Expression of Murine PPAR{gamma} in Adipose Tissue during Endotoxemia VL - 138 SP - 3073 KW - adipose_tissue KW - endotoxemia KW - ppar-gamma AU - Hill, Molly AU - Young, Misty AU - Mccurdy, Caren AU - Gimble, Jeffrey PY - 1997/07/01/ UR - http://dx.doi.org/10.1210/en.138.7.3073 ER -