doi: 10.1086/595618 ABSTRACT A representative sample of unevolved early B-type stars in nearby OB associations and the field is analyzed to unprecedented precision using NLTE techniques. The resulting chemical composition is found to be more metal-rich and much more homogeneous than indicated by previous work. A rms scatter of 10% in abundances is found for the six stars (and confirmed by six evolved stars), the same as reported for ISM gas-phase abundances. A cosmic abundance standard for the present-day solar neighborhood is proposed, implying mass fractions for hydrogen, helium, and metals of $X=0.715$ , $Y=0.271$ , and $Z=0.014$ . Good agreement with solar photospheric abundances as reported from recent 3D radiative-hydrodynamical simulations of the solar atmosphere is obtained. As a first application we use the cosmic abundance standard as a proxy for the determination of the local ISM dust-phase composition, putting tight observational constraints on dust models.