Dysfunction of Ca2+/CaM kinase IIalpha cascades in the amygdala in post-traumatic stress disorder. Export

@article{citeulike:6081031, abstract = {Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The calcium (Ca2+)-calmodulin (CaM)-CaM kinase (K)IIalpha signal passage plays an important role in the plasticity of central nervous, learning and memory, mind and behavior and other types of cognitive activities. The amygdala is known to play an important role in fear, rage and emotional memory. In this study, we investigated changes in Ca2+-CaM-CaMKIIalpha in the basolateral amygdala of rats after SPS which may reveal part of the pathogenesis of PTSD. The intracellular free calcium level in the basolateral amygdala was examined by fluorescence spectrophotometry. CaM and CaMKIIalpha expression in basolateral amygdala was examined using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction. The intracellular free calcium level in the basolateral amygdala was increased when compared to that in the control group 1 day after SPS exposure (P<0.05). CaM expression significantly increased, and CaMKIIalpha expression significantly decreased (P<0.05) in the basolateral amygdala after SPS. These findings suggest dysfunction of Ca2+-CaM-CaMKIIalpha in the basolateral amygdala of SPS rats, which may play important roles in the pathogenesis of PTSD rats.}, author = {Xiao, Bing and Han, Fang and Shi, Yu-Xiu X.}, citeulike-article-id = {6081031}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19885620}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19885620}, issn = {1791-244X}, journal = {International journal of molecular medicine}, keywords = {camkiiptsd}, month = {December}, number = {6}, pages = {795--799}, posted-at = {2009-11-06 15:14:57}, priority = {3}, title = {Dysfunction of Ca2+/CaM kinase IIalpha cascades in the amygdala in post-traumatic stress disorder.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/19885620}, volume = {24}, year = {2009} }

TY - JOUR ID - citeulike:6081031 L3 - citeulike-article-id:6081031 N2 - Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The calcium (Ca2+)-calmodulin (CaM)-CaM kinase (K)IIalpha signal passage plays an important role in the plasticity of central nervous, learning and memory, mind and behavior and other types of cognitive activities. The amygdala is known to play an important role in fear, rage and emotional memory. In this study, we investigated changes in Ca2+-CaM-CaMKIIalpha in the basolateral amygdala of rats after SPS which may reveal part of the pathogenesis of PTSD. The intracellular free calcium level in the basolateral amygdala was examined by fluorescence spectrophotometry. CaM and CaMKIIalpha expression in basolateral amygdala was examined using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction. The intracellular free calcium level in the basolateral amygdala was increased when compared to that in the control group 1 day after SPS exposure (P<0.05). CaM expression significantly increased, and CaMKIIalpha expression significantly decreased (P<0.05) in the basolateral amygdala after SPS. These findings suggest dysfunction of Ca2+-CaM-CaMKIIalpha in the basolateral amygdala of SPS rats, which may play important roles in the pathogenesis of PTSD rats. IS - 6 JF - International journal of molecular medicine SN - 1791-244X EP - 799 TI - Dysfunction of Ca2+/CaM kinase IIalpha cascades in the amygdala in post-traumatic stress disorder. VL - 24 SP - 795 KW - camkiiptsd AU - Xiao, Bing AU - Han, Fang AU - Shi, Yu-Xiu PY - 2009/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/19885620 ER -