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The meaning of gene positioning.
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Cell, Vol. 135, No. 1. (3 October 2008), pp. 9-13.
Abstract
There is no doubt that genomes are organized nonrandomly in the nucleus of higher eukaryotes. But what is the functional relevance of this nonrandomness? In this Essay, we explore the biological meaning of spatial gene positioning by examining the functional link between the activity of a gene and its radial position in the nucleus.
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