The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes? Export

@article{citeulike:3510337, abstract = {Obesity and type 2 diabetes arise from a set of complex gene-environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the ldquothrifty genotyperdquo and the ldquothrifty phenotyperdquo hypotheses. Here, the merits of both models are discussed and elements of them are used to synthesize a ldquothrifty epigenotyperdquo hypothesis. I propose that: (1) metabolic thrift, the capacity for efficient acquisition, storage and use of energy, is an ancient, complex trait, (2) the environmentally responsive gene network encoding this trait is subject to genetic canalization and thereby has become robust against mutational perturbations, (3) DNA sequence polymorphisms play a minor role in the aetiology of obesity and type 2 diabetes - instead, disease susceptibility is predominantly determined by epigenetic variations, (4) corresponding epigenotypes have the potential to be inherited across generations, and (5) Leptin is a candidate gene for the acquisition of a thrifty epigenotype. BioEssays 30:156-166, 2008. {\copyright} 2008 Wiley Periodicals, Inc.}, address = {Department of Biology, University of Washington, Department of Biology, Box 351800, Seattle WA 98195-0002}, author = {St\"{o}ger, Reinhard}, citeulike-article-id = {3510337}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/bies.20700}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/117885938/ABSTRACT}, doi = {10.1002/bies.20700}, journal = {BioEssays}, keywords = {development, diabetes, epigenetics, evolution, genotype, obesity, read, thrifty}, number = {2}, pages = {156--166}, posted-at = {2008-11-13 22:59:40}, priority = {2}, title = {The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?}, url = {http://dx.doi.org/10.1002/bies.20700}, volume = {30}, year = {2008} }

TY - JOUR ID - citeulike:3510337 L3 - citeulike-article-id:3510337 N2 - Obesity and type 2 diabetes arise from a set of complex gene-environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the ldquothrifty genotyperdquo and the ldquothrifty phenotyperdquo hypotheses. Here, the merits of both models are discussed and elements of them are used to synthesize a ldquothrifty epigenotyperdquo hypothesis. I propose that: (1) metabolic thrift, the capacity for efficient acquisition, storage and use of energy, is an ancient, complex trait, (2) the environmentally responsive gene network encoding this trait is subject to genetic canalization and thereby has become robust against mutational perturbations, (3) DNA sequence polymorphisms play a minor role in the aetiology of obesity and type 2 diabetes - instead, disease susceptibility is predominantly determined by epigenetic variations, (4) corresponding epigenotypes have the potential to be inherited across generations, and (5) Leptin is a candidate gene for the acquisition of a thrifty epigenotype. BioEssays 30:156-166, 2008. © 2008 Wiley Periodicals, Inc. IS - 2 JF - BioEssays AD - Department of Biology, University of Washington, Department of Biology, Box 351800, Seattle WA 98195-0002 EP - 166 TI - The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes? VL - 30 SP - 156 KW - development KW - diabetes KW - epigenetics KW - evolution KW - genotype KW - obesity KW - read KW - thrifty AU - Stöger, Reinhard PY - 2008/// UR - http://dx.doi.org/10.1002/bies.20700 ER -