The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself. Export

@article{citeulike:383065, abstract = {Actin is the major constituent of the cytoskeleton of almost all the eukaryotic cells. In vitro experiments have indicated that oxidant-stressed nonmuscle mammalian cells undergo remarkable changes in their morphology and in the structure of the actin cytoskeleton, often resulting in plasma membrane blebbing. Although the microfilament network is one of the earliest targets of oxidative stress, the mechanism by which oxidants change both the structure and the spatial organization of actin filaments is still a matter of debate and far from being fully elucidated. Starting from the 2-fold role of oxidants as injurious by-products of cellular metabolism and essential participants in cell signaling and regulation, this review attempts to gather the most relevant information related to (i) the activation of mitogen-activated protein (MAP) kinase stress-activated protein kinase-2/p38 (SAPK2/p38) which, via MAP kinase-activated protein (MAPKAP) kinase 2/3, leads to the phosphorylation of the actin polymerization (F-actin) modulator 25/27 kDa heat shock protein (HSP25/27), whose phosphorylation is causally related to the regulation of microfilament dynamics following oxidative stress; (ii) the alteration of the redox state of actin or some actin regulatory proteins. The actin cytoskeleton response to oxidants is discussed on the basis of the growing body of evidence indicating the actin system as the most sensitive constituent of the cytoskeleton to the oxidant attack.}, address = {Department of Biology, University of Milan, Milan, Italy.}, author = {Dalle-Donne, I. and Rossi, R. and Milzani, A. and Di Simplicio, P. and Colombo, R.}, citeulike-article-id = {383065}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11744337}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11744337}, day = {15}, issn = {0891-5849}, journal = {Free Radic Biol Med}, keywords = {actin, actin\_cytoskeleton, heat\_shock\_protein, hsp27}, month = {December}, number = {12}, pages = {1624--1632}, posted-at = {2008-11-29 18:15:55}, priority = {2}, title = {The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11744337}, volume = {31}, year = {2001} }

TY - JOUR ID - citeulike:383065 L3 - citeulike-article-id:383065 N2 - Actin is the major constituent of the cytoskeleton of almost all the eukaryotic cells. In vitro experiments have indicated that oxidant-stressed nonmuscle mammalian cells undergo remarkable changes in their morphology and in the structure of the actin cytoskeleton, often resulting in plasma membrane blebbing. Although the microfilament network is one of the earliest targets of oxidative stress, the mechanism by which oxidants change both the structure and the spatial organization of actin filaments is still a matter of debate and far from being fully elucidated. Starting from the 2-fold role of oxidants as injurious by-products of cellular metabolism and essential participants in cell signaling and regulation, this review attempts to gather the most relevant information related to (i) the activation of mitogen-activated protein (MAP) kinase stress-activated protein kinase-2/p38 (SAPK2/p38) which, via MAP kinase-activated protein (MAPKAP) kinase 2/3, leads to the phosphorylation of the actin polymerization (F-actin) modulator 25/27 kDa heat shock protein (HSP25/27), whose phosphorylation is causally related to the regulation of microfilament dynamics following oxidative stress; (ii) the alteration of the redox state of actin or some actin regulatory proteins. The actin cytoskeleton response to oxidants is discussed on the basis of the growing body of evidence indicating the actin system as the most sensitive constituent of the cytoskeleton to the oxidant attack. IS - 12 JF - Free Radic Biol Med SN - 0891-5849 AD - Department of Biology, University of Milan, Milan, Italy. EP - 1632 TI - The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself. VL - 31 SP - 1624 KW - actin KW - actin_cytoskeleton KW - heat_shock_protein KW - hsp27 AU - Dalle-Donne, I AU - Rossi, R AU - Milzani, A AU - Di Simplicio, P AU - Colombo, R PY - 2001/12/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11744337 ER -