Racial Differences in Premenopausal Endogenous Hormones Export

@article{citeulike:3558345, abstract = {Differences in breast cancer incidence across racial groups are well documented. African Americans have the highest rates of premenopausal breast cancer and Asians have lower breast cancer rates across all age groups. We hypothesized that levels of premenopausal endogenous hormones and growth factors, risk factors that have been predictive of breast cancer, would differ by race. Using a cross-sectional study design, we tested this hypothesis in the Nurses' Health Study II. We assayed estradiol, progesterone, prolactin, sex hormone binding globulin (SHBG), insulin-like growth factor-I (IGF-I), and IGFBP-3 in 111 African American and 111 Asian American women, matched to 111 Caucasian women on age, day of luteal phase, and day, time, and fasting status at blood collection. We analyzed the association between race and hormone levels using robust linear regression methods. In multivariate models, compared with Caucasians, African Americans had 18\% higher levels of estradiol (P < 0.01), 17\% higher free estradiol (P < 0.01), 11\% lower SHBG (P = 0.05), 11\% higher IGF-I (P < 0.01), 25\% higher free IGF-I (P < 0.01), and 9\% lower IGFBP-3 (P < 0.01) levels. In multivariate models, compared with Caucasian women, Asian Americans had 22\% higher calculated free estradiol (P < 0.01), 31\% lower SHBG (P < 0.01), and 25\% higher free IGF-I (P < 0.01) levels. No racial differences were found in progesterone and prolactin levels. Our study showed hormone differences consistent with breast cancer risk between Caucasians and African Americans but inconsistent with breast cancer risk between Asian Americans and Caucasians. Further research is needed to explore differences across racial groups and the link between endogenous hormones and breast cancer risk. 10.1158/1055-9965.EPI-04-0944}, author = {Pinheiro, Simone P. and Holmes, Michelle D. and Pollak, Michael N. and Barbieri, Robert L. and Hankinson, Susan E.}, citeulike-article-id = {3558345}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1055-9965.EPI-04-0944}, citeulike-linkout-1 = {http://cebp.aacrjournals.org/cgi/content/abstract/14/9/2147}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16172224}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16172224}, day = {1}, doi = {10.1158/1055-9965.EPI-04-0944}, journal = {Cancer Epidemiol Biomarkers Prev}, keywords = {african-american, asian, caucasian, comparisons, estrogen, hormone, population, premenopausal, race}, month = {September}, number = {9}, pages = {2147--2153}, posted-at = {2008-11-17 13:22:10}, priority = {2}, title = {Racial Differences in Premenopausal Endogenous Hormones}, url = {http://dx.doi.org/10.1158/1055-9965.EPI-04-0944}, volume = {14}, year = {2005} }

TY - JOUR ID - citeulike:3558345 L3 - citeulike-article-id:3558345 N2 - Differences in breast cancer incidence across racial groups are well documented. African Americans have the highest rates of premenopausal breast cancer and Asians have lower breast cancer rates across all age groups. We hypothesized that levels of premenopausal endogenous hormones and growth factors, risk factors that have been predictive of breast cancer, would differ by race. Using a cross-sectional study design, we tested this hypothesis in the Nurses' Health Study II. We assayed estradiol, progesterone, prolactin, sex hormone binding globulin (SHBG), insulin-like growth factor-I (IGF-I), and IGFBP-3 in 111 African American and 111 Asian American women, matched to 111 Caucasian women on age, day of luteal phase, and day, time, and fasting status at blood collection. We analyzed the association between race and hormone levels using robust linear regression methods. In multivariate models, compared with Caucasians, African Americans had 18% higher levels of estradiol (P < 0.01), 17% higher free estradiol (P < 0.01), 11% lower SHBG (P = 0.05), 11% higher IGF-I (P < 0.01), 25% higher free IGF-I (P < 0.01), and 9% lower IGFBP-3 (P < 0.01) levels. In multivariate models, compared with Caucasian women, Asian Americans had 22% higher calculated free estradiol (P < 0.01), 31% lower SHBG (P < 0.01), and 25% higher free IGF-I (P < 0.01) levels. No racial differences were found in progesterone and prolactin levels. Our study showed hormone differences consistent with breast cancer risk between Caucasians and African Americans but inconsistent with breast cancer risk between Asian Americans and Caucasians. Further research is needed to explore differences across racial groups and the link between endogenous hormones and breast cancer risk. 10.1158/1055-9965.EPI-04-0944 IS - 9 JF - Cancer Epidemiol Biomarkers Prev EP - 2153 TI - Racial Differences in Premenopausal Endogenous Hormones VL - 14 SP - 2147 KW - african-american KW - asian KW - caucasian KW - comparisons KW - estrogen KW - hormone KW - population KW - premenopausal KW - race AU - Pinheiro, Simone AU - Holmes, Michelle AU - Pollak, Michael AU - Barbieri, Robert AU - Hankinson, Susan PY - 2005/09/01/ UR - http://dx.doi.org/10.1158/1055-9965.EPI-04-0944 ER -