Steroid and gonadotropin hormone levels in young African women with filarial infection☆ Export

@article{citeulike:3680329, abstract = {Serum levels of dehydroepiandrosterone sulfate (DHEAS), testosterone (T), progesterone (P), estradiol (E2), prolactin (PRL), cortisol (F) and gonadotropins (FSH, LH) were analysed by radioimmunoassay for 125 schoolgirls aged 14–16, in a zone of endemic filariasis 3 days after menses. Two groups were identified: the infected group in which 38 subjects had circulating Loa loa and or Mansonella perstans microfilariae as determined by the Knott's concentration technique, and the non-infected group (87 subjects without microfilaremia). All results are expressed as the mean ± SD. No significant difference was found between the two groups for age (14.47 ± 1.37 yr vs 14.50 ± 1.37 yr) or for body wt (46.10 ± 8.45 kg vs 47.06 ± 8.26 kg). There was a tendency to lower levels of DHEAS in the infected group by comparison with controls (54.92 ± 37.34 μg/dl vs 66.80 ± 47.18 μg/dl) while in the same infected group more subjects had higher levels of prolactin by comparison with the control group (10.85 ± 14.16 μg/ml vs 9.80 ± 5.56 ng/ml). Testosterone, progesterone, estradiol levels and the LH/FSH ratio were lower in the infected group than in the non-infected group (P: 0.25 ± 0.12 ng/ml vs 0.33 ± 0.20 ng/ml, P < 0.025; T: 0.55 ± 0.17 ng/ml vs 0.62 ±0.19 ng/ml, P < 0.05; E2: 32.95 ± 19.63 pg/ml vs 66.98 ± 54.83 pg/ml, P < 0.001; LH/FSH: 0.91 ± 0.44 vs 1.30 ± 0.84, P < 0.005) respectively. No significant difference was found between the two groups for F; however FSH levels correlated negatively with F levels only in the microfilaremia group (r = − 0.38, n = 38, P < 0.05). Our results suggest that the presence of microfilaremia in our subjects may have contributed to reduced steroid levels, perhaps by involvement of the cyclic AMP kinase system. These observations may explain the delayed menarche and androgen secretion found during puberty in a similar population living in the same zone of endemic filariasis. Microfilaremia should therefore be considered an environmental factor which mediates endocrine disorders in subjects living in tropical filariasis areas.}, author = {Mavoungou, D. and Lansoudsoukate, J. and Dupont, A.}, citeulike-article-id = {3680329}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0022-4731(89)90149-0}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/0022473189901490}, doi = {10.1016/0022-4731(89)90149-0}, issn = {00224731}, journal = {Journal of Steroid Biochemistry}, keywords = {africa, estrogen, filariasis, hormone, measurement, population, steroid}, number = {1-6}, pages = {577--580}, posted-at = {2008-11-24 07:31:31}, priority = {2}, title = {Steroid and gonadotropin hormone levels in young African women with filarial infection☆}, url = {http://dx.doi.org/10.1016/0022-4731(89)90149-0}, volume = {34}, year = {1989} }

TY - JOUR ID - citeulike:3680329 L3 - citeulike-article-id:3680329 N2 - Serum levels of dehydroepiandrosterone sulfate (DHEAS), testosterone (T), progesterone (P), estradiol (E2), prolactin (PRL), cortisol (F) and gonadotropins (FSH, LH) were analysed by radioimmunoassay for 125 schoolgirls aged 14–16, in a zone of endemic filariasis 3 days after menses. Two groups were identified: the infected group in which 38 subjects had circulating Loa loa and or Mansonella perstans microfilariae as determined by the Knott's concentration technique, and the non-infected group (87 subjects without microfilaremia). All results are expressed as the mean ± SD. No significant difference was found between the two groups for age (14.47 ± 1.37 yr vs 14.50 ± 1.37 yr) or for body wt (46.10 ± 8.45 kg vs 47.06 ± 8.26 kg). There was a tendency to lower levels of DHEAS in the infected group by comparison with controls (54.92 ± 37.34 μg/dl vs 66.80 ± 47.18 μg/dl) while in the same infected group more subjects had higher levels of prolactin by comparison with the control group (10.85 ± 14.16 μg/ml vs 9.80 ± 5.56 ng/ml). Testosterone, progesterone, estradiol levels and the LH/FSH ratio were lower in the infected group than in the non-infected group (P: 0.25 ± 0.12 ng/ml vs 0.33 ± 0.20 ng/ml, P < 0.025; T: 0.55 ± 0.17 ng/ml vs 0.62 ±0.19 ng/ml, P < 0.05; E2: 32.95 ± 19.63 pg/ml vs 66.98 ± 54.83 pg/ml, P < 0.001; LH/FSH: 0.91 ± 0.44 vs 1.30 ± 0.84, P < 0.005) respectively. No significant difference was found between the two groups for F; however FSH levels correlated negatively with F levels only in the microfilaremia group (r = − 0.38, n = 38, P < 0.05). Our results suggest that the presence of microfilaremia in our subjects may have contributed to reduced steroid levels, perhaps by involvement of the cyclic AMP kinase system. These observations may explain the delayed menarche and androgen secretion found during puberty in a similar population living in the same zone of endemic filariasis. Microfilaremia should therefore be considered an environmental factor which mediates endocrine disorders in subjects living in tropical filariasis areas. IS - 1-6 JF - Journal of Steroid Biochemistry SN - 00224731 EP - 580 TI - Steroid and gonadotropin hormone levels in young African women with filarial infection☆ VL - 34 SP - 577 KW - africa KW - estrogen KW - filariasis KW - hormone KW - measurement KW - population KW - steroid AU - Mavoungou, D AU - Lansoudsoukate, J AU - Dupont, A PY - 1989/// UR - http://dx.doi.org/10.1016/0022-4731(89)90149-0 ER -