Pharmacogenetics of catechol-O-methyltransferase: Frequency of low activity allele in a Ghanaian population Export

@article{citeulike:3681736, abstract = {Catechol-O-methyltransferase (COMT) catalyses the O-methylation of neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. Ethnic differences in COMT activity have been observed in several populations. Previous studies suggest that the g1947G\>A low activity allele is less common in individuals of African origin. COMT genotyping was performed using a mini-sequencing method in 195 healthy Ghanaians with a frequency of the homozygous g1947G\>A of 6\%. This study provides confirmation that the low activity COMT allele is less common in individuals of African origin. This finding may be important clinically with regards to the treatment of many neuropsychiatric disorders and in the pathophysiology of various human disorders including estrogen-induced cancers, Parkinson's disease, depression and hypertension. {\copyright} 2000 Wiley-Liss, Inc.}, address = {Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK; Division of Molecular Medicine, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland; Centre for Tropical Clinical Pharmacology, University of Ghana Medical School, Accra, Ghana}, author = {Ameyaw, Margaret-Mary and Syv\"{a}nen, Ann-Christine and Ulmanen, Ismo and Ofori-Adjei, David and Mcleod, Howard L.}, citeulike-article-id = {3681736}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/1098-1004(200011)16:5%3C445::AID-HUMU13%3E3.0.CO;2-3}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/74500569/ABSTRACT}, doi = {10.1002/1098-1004(200011)16:5%3C445::AID-HUMU13%3E3.0.CO;2-3}, journal = {Human Mutation}, keywords = {africa, comt, estrogen, ghana}, number = {5}, pages = {445--446}, posted-at = {2008-11-24 19:08:14}, priority = {2}, title = {Pharmacogenetics of catechol-O-methyltransferase: Frequency of low activity allele in a Ghanaian population}, url = {http://dx.doi.org/10.1002/1098-1004(200011)16:5%3C445::AID-HUMU13%3E3.0.CO;2-3}, volume = {16}, year = {2000} }

TY - JOUR ID - citeulike:3681736 L3 - citeulike-article-id:3681736 N2 - Catechol-O-methyltransferase (COMT) catalyses the O-methylation of neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. Ethnic differences in COMT activity have been observed in several populations. Previous studies suggest that the g1947G>A low activity allele is less common in individuals of African origin. COMT genotyping was performed using a mini-sequencing method in 195 healthy Ghanaians with a frequency of the homozygous g1947G>A of 6%. This study provides confirmation that the low activity COMT allele is less common in individuals of African origin. This finding may be important clinically with regards to the treatment of many neuropsychiatric disorders and in the pathophysiology of various human disorders including estrogen-induced cancers, Parkinson's disease, depression and hypertension. © 2000 Wiley-Liss, Inc. IS - 5 JF - Human Mutation AD - Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK; Division of Molecular Medicine, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland; Centre for Tropical Clinical Pharmacology, University of Ghana Medical School, Accra, Ghana EP - 446 TI - Pharmacogenetics of catechol-O-methyltransferase: Frequency of low activity allele in a Ghanaian population VL - 16 SP - 445 KW - africa KW - comt KW - estrogen KW - ghana AU - Ameyaw, Margaret-Mary AU - Syvänen, Ann-Christine AU - Ulmanen, Ismo AU - Ofori-Adjei, David AU - Mcleod, Howard PY - 2000/// UR - http://dx.doi.org/10.1002/1098-1004(200011)16:5%3C445::AID-HUMU13%3E3.0.CO;2-3 ER -