Endocannabinoid-mediated synaptic plasticity in the CNS.

@article{citeulike:1580380, abstract = {Changes in synaptic efficacy are thought to be crucial to experience-dependent modifications of neural function. The diversity of mechanisms underlying these changes is far greater than previously expected. In the last five years, a new class of use-dependent synaptic plasticity that requires retrograde signaling by endocannabinoids (eCB) and presynaptic CB1 receptor activation has been identified in several brain structures. eCB-mediated plasticity encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses. In addition, eCBs can modify the inducibility of non-eCB-mediated forms of plasticity. Thus, the eCB system is emerging as a major player in synaptic plasticity. Given the wide distribution of CB1 receptors in the CNS, the list of brain structures and synapses expressing eCB-mediated plasticity is likely to expand.}, address = {Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.}, author = {Chevaleyre, V. and Takahashi, K. A. and Castillo, P. E. }, citeulike-article-id = {1580380}, doi = {http://dx.doi.org/10.1146/annurev.neuro.29.051605.112834}, issn = {0147-006X}, journal = {Annu Rev Neurosci}, keywords = {cannabis, endocannabinoid, neuron, plasticity, retrograde, signalling, synaptic}, pages = {37--76}, posted-at = {2007-08-21 15:59:44}, priority = {4}, title = {Endocannabinoid-mediated synaptic plasticity in the CNS.}, url = {http://dx.doi.org/10.1146/annurev.neuro.29.051605.112834}, volume = {29}, year = {2006} }

TY - JOUR ID - citeulike:1580380 L3 - citeulike-article-id:1580380 TI - Endocannabinoid-mediated synaptic plasticity in the CNS. JF - Annu Rev Neurosci VL - 29 SP - 37 EP - 76 AD - Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA. SN - 0147-006X N2 - Changes in synaptic efficacy are thought to be crucial to experience-dependent modifications of neural function. The diversity of mechanisms underlying these changes is far greater than previously expected. In the last five years, a new class of use-dependent synaptic plasticity that requires retrograde signaling by endocannabinoids (eCB) and presynaptic CB1 receptor activation has been identified in several brain structures. eCB-mediated plasticity encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses. In addition, eCBs can modify the inducibility of non-eCB-mediated forms of plasticity. Thus, the eCB system is emerging as a major player in synaptic plasticity. Given the wide distribution of CB1 receptors in the CNS, the list of brain structures and synapses expressing eCB-mediated plasticity is likely to expand. KW - cannabis KW - endocannabinoid KW - neuron KW - plasticity KW - retrograde KW - signalling KW - synaptic AU - Chevaleyre, V AU - Takahashi, KA AU - Castillo, PE PY - 2006/// UR - http://dx.doi.org/10.1146/annurev.neuro.29.051605.112834 ER -