ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information. Export

@article{citeulike:411306, abstract = {SUMMARY: We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server, ConSurf, which automates these algorithmic tools. ConSurf may be used for high-throughput characterization of functional regions in proteins. AVAILABILITY: The ConSurf web server is available at:http://consurf.tau.ac.il. SUPPLEMENTARY INFORMATION: A set of examples is available at http://consurf.tau.ac.il under 'GALLERY'.}, address = {The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel. fabian@ashtoret.tau.ac.il}, author = {Glaser, F. and Pupko, T. and Paz, I. and Bell, R. E. and Bechor-Shental, D. and Martz, E. and Ben-Tal, N.}, citeulike-article-id = {411306}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12499312}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12499312}, issn = {1367-4803}, journal = {Bioinformatics}, keywords = {docking, docking\_prog}, month = {January}, number = {1}, pages = {163--164}, posted-at = {2009-04-03 17:05:47}, priority = {2}, title = {ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12499312}, volume = {19}, year = {2003} }

TY - JOUR ID - citeulike:411306 L3 - citeulike-article-id:411306 N2 - SUMMARY: We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server, ConSurf, which automates these algorithmic tools. ConSurf may be used for high-throughput characterization of functional regions in proteins. AVAILABILITY: The ConSurf web server is available at:http://consurf.tau.ac.il. SUPPLEMENTARY INFORMATION: A set of examples is available at http://consurf.tau.ac.il under 'GALLERY'. IS - 1 JF - Bioinformatics SN - 1367-4803 AD - The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel. fabian@ashtoret.tau.ac.il EP - 164 TI - ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information. VL - 19 SP - 163 KW - docking KW - docking_prog AU - Glaser, F AU - Pupko, T AU - Paz, I AU - Bell, RE AU - Bechor-Shental, D AU - Martz, E AU - Ben-Tal, N PY - 2003/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/12499312 ER -