Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome Export

@article{citeulike:3796554, abstract = {The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p \&\#60; 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.}, author = {Ursavas, Ahmet and Karadag, Mehmet and Ilcol, Yesim and Ercan, Ilker and Burgazlioglu, Basak and Coskun, Funda and Gozu, R.}, citeulike-article-id = {3796554}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00408-007-9026-x}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/klu/408/2007/00000185/00000005/00009026}, doi = {10.1007/s00408-007-9026-x}, issn = {0341-2040}, journal = {Lung}, keywords = {igf-1, obesity, sleep\_apnea}, month = {September}, pages = {309--314}, posted-at = {2008-12-16 13:41:59}, priority = {3}, publisher = {Springer}, title = {Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome}, url = {http://dx.doi.org/10.1007/s00408-007-9026-x}, year = {2007} }

TY - JOUR ID - citeulike:3796554 L3 - citeulike-article-id:3796554 N2 - The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1. JF - Lung SN - 0341-2040 EP - 314 TI - Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome PB - Springer SP - 309 KW - igf-1 KW - obesity KW - sleep_apnea AU - Ursavas, Ahmet AU - Karadag, Mehmet AU - Ilcol, Yesim AU - Ercan, Ilker AU - Burgazlioglu, Basak AU - Coskun, Funda AU - Gozu, R PY - 2007/09// UR - http://dx.doi.org/10.1007/s00408-007-9026-x ER -