Killer applications: Toward affordable rapid cell-based diagnostics for malaria and tuberculosis Export

@article{citeulike:3924104, abstract = {In many resource-poor areas, the HIV/AIDS epidemic coexists with epidemics of two much older diseases, malaria and tuberculosis, and the three diseases together kill approximately six million people per year. Although HIV/AIDS is treatable, but not curable, many if not most cases of malaria and tuberculosis (TB) can be cured if diagnosed correctly and promptly. The diagnosis of both malaria and TB is cell-based, typically made by microscopy of stained smears of blood (malaria) and sputum (TB). Cytometry has been shown to be effective for diagnosis of both conditions; however, conventional cytometers have been too complex and costly to be widely applied. It is likely that a newly developed small, simple, robust, inexpensive, energy-efficient low-resolution fluorescence image cytometer, employing a light-emitting diode for excitation and a megapixel digital camera chip for detection, could be used in resource-poor areas for malaria and TB diagnosis and for rapid (24-48 h) determination of antimicrobial susceptibility of Mycobacterium tuberculosis. {\copyright} 2008 Clinical Cytometry Society}, address = {The Center for Microbial Cytometry, West Newton, Massachusetts 02465-2513; Howard M. Shapiro, M.D., P.C., West Newton, Massachusetts 02465-2513}, author = {Shapiro, Howard M. and Perlmutter, Nancy G.}, citeulike-article-id = {3924104}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/cyto.b.20401}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/117899957/ABSTRACT}, doi = {10.1002/cyto.b.20401}, journal = {Cytometry Part B: Clinical Cytometry}, keywords = {antimicrobial, cytometry, diagnosis, fluorescence, malaria, susceptibility, testing, tuberculosis}, number = {S1}, pages = {S152--S164}, posted-at = {2009-01-22 15:11:20}, priority = {2}, title = {Killer applications: Toward affordable rapid cell-based diagnostics for malaria and tuberculosis}, url = {http://dx.doi.org/10.1002/cyto.b.20401}, volume = {74B}, year = {2008} }

TY - JOUR ID - citeulike:3924104 L3 - citeulike-article-id:3924104 N2 - In many resource-poor areas, the HIV/AIDS epidemic coexists with epidemics of two much older diseases, malaria and tuberculosis, and the three diseases together kill approximately six million people per year. Although HIV/AIDS is treatable, but not curable, many if not most cases of malaria and tuberculosis (TB) can be cured if diagnosed correctly and promptly. The diagnosis of both malaria and TB is cell-based, typically made by microscopy of stained smears of blood (malaria) and sputum (TB). Cytometry has been shown to be effective for diagnosis of both conditions; however, conventional cytometers have been too complex and costly to be widely applied. It is likely that a newly developed small, simple, robust, inexpensive, energy-efficient low-resolution fluorescence image cytometer, employing a light-emitting diode for excitation and a megapixel digital camera chip for detection, could be used in resource-poor areas for malaria and TB diagnosis and for rapid (24-48 h) determination of antimicrobial susceptibility of Mycobacterium tuberculosis. © 2008 Clinical Cytometry Society IS - S1 JF - Cytometry Part B: Clinical Cytometry AD - The Center for Microbial Cytometry, West Newton, Massachusetts 02465-2513; Howard M. Shapiro, M.D., P.C., West Newton, Massachusetts 02465-2513 EP - S164 TI - Killer applications: Toward affordable rapid cell-based diagnostics for malaria and tuberculosis VL - 74B SP - S152 KW - antimicrobial KW - cytometry KW - diagnosis KW - fluorescence KW - malaria KW - susceptibility KW - testing KW - tuberculosis AU - Shapiro, Howard AU - Perlmutter, Nancy PY - 2008/// UR - http://dx.doi.org/10.1002/cyto.b.20401 ER -