Using parsimony analysis, a phylogeny for the southern African species of Disperis is derived. This shows that of the 26 species found in southern Africa, three belong to a largely tropical clade (used as the outgroup for this study), while the rest belong to an almost exclusively southern African clade. The phytogeography of the southern African clade is analysed and it is shown that three centres can be recognized. The pattern found, that Namaqualand is the sister area to the south-western Cape and that both combined form the sister area to the Drakensberg, confirms that reported by other studies. An analysis of the speciation patterns for terminal sister-species showed that allopatry plays a relatively minor role (in two of the six sister pairs) and that pollinator isolation, either by different pollinators (two of the six pairs) or by differential placement of the pollinia on the pollination (three of the six pairs) is important. In three of the six pairs the species are sympatric and the mechanism of speciation remains obscure.