Microsatellite data support subpopulation structuring among Basques Export

@article{citeulike:527282, abstract = {Genomic diversity based on 13 short tandem repeat (STR) loci (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, TH01, TPOX, and CSF1PO) is reported for the first time in Basques from the provinces of Guip\'{u}zcoa and Navarre (Spain). STR data from previous studies on Basques from Alava and Vizcaya provinces were also examined using hierarchal analysis of molecular variance (AMOVA) and genetic admixture estimations to ascertain whether the Basques are genetically heterogeneous. To assess the genetic position of Basques in a broader geographic context, we conducted phylogenetic analyses based on FST genetic distances [neighbor-joining trees and multidimensional scaling (MDS)] using data compiled in previous publications. The genetic profile of the Basque groups revealed distinctive regional partitioning of short tandem repeat (STR) diversity. Consistent with the above, native Basques clearly segregated from other populations from Europe (including Spain), North Africa, and the Middle East. The main line of genetic discontinuity inferred from the spatial variability of the microsatellite diversity in Basques significantly overlapped the geographic distribution of the Basque language. The genetic heterogeneity among native Basque groups correlates with the peculiar geography of peopling and marital structure in rural Basque zones and with language boundaries resulting from the uneven impact of Romance languages in the different Basque territories.}, address = {Molecular Biology and Human Diversity Laboratory, Department of Biological Sciences, Florida International University, Miami, FL 33199, USA.}, author = {P\'{e}rez-Miranda, Ana and Alfonso-S\'{a}nchez, Miguel and Kalantar, Arif and Garc\'{\i}a-Obreg\'{o}n, Susana and Pancorbo, Marian and Pe\~{n}a, Jos\'{e} and Herrera, Rene}, citeulike-article-id = {527282}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s10038-005-0268-2}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16133660}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16133660}, citeulike-linkout-3 = {http://www.springerlink.com/content/n448g381366u4208}, day = {28}, doi = {10.1007/s10038-005-0268-2}, issn = {1434-5161}, journal = {Journal of Human Genetics}, keywords = {basque, str}, month = {September}, number = {8}, pages = {403--414}, posted-at = {2006-03-02 17:45:33}, priority = {2}, title = {Microsatellite data support subpopulation structuring among Basques}, url = {http://dx.doi.org/10.1007/s10038-005-0268-2}, volume = {50}, year = {2005} }

TY - JOUR ID - citeulike:527282 L3 - citeulike-article-id:527282 N2 - Genomic diversity based on 13 short tandem repeat (STR) loci (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, TH01, TPOX, and CSF1PO) is reported for the first time in Basques from the provinces of Guipúzcoa and Navarre (Spain). STR data from previous studies on Basques from Alava and Vizcaya provinces were also examined using hierarchal analysis of molecular variance (AMOVA) and genetic admixture estimations to ascertain whether the Basques are genetically heterogeneous. To assess the genetic position of Basques in a broader geographic context, we conducted phylogenetic analyses based on FST genetic distances [neighbor-joining trees and multidimensional scaling (MDS)] using data compiled in previous publications. The genetic profile of the Basque groups revealed distinctive regional partitioning of short tandem repeat (STR) diversity. Consistent with the above, native Basques clearly segregated from other populations from Europe (including Spain), North Africa, and the Middle East. The main line of genetic discontinuity inferred from the spatial variability of the microsatellite diversity in Basques significantly overlapped the geographic distribution of the Basque language. The genetic heterogeneity among native Basque groups correlates with the peculiar geography of peopling and marital structure in rural Basque zones and with language boundaries resulting from the uneven impact of Romance languages in the different Basque territories. IS - 8 JF - Journal of Human Genetics SN - 1434-5161 AD - Molecular Biology and Human Diversity Laboratory, Department of Biological Sciences, Florida International University, Miami, FL 33199, USA. EP - 414 TI - Microsatellite data support subpopulation structuring among Basques VL - 50 SP - 403 KW - basque KW - str AU - Pérez-Miranda, Ana AU - Alfonso-Sánchez, Miguel AU - Kalantar, Arif AU - García-Obregón, Susana AU - Pancorbo, Marian AU - Peña, José AU - Herrera, Rene PY - 2005/09/28/ UR - http://dx.doi.org/10.1007/s10038-005-0268-2 ER -