Heritability in the genomics era |[mdash]| concepts and misconceptions Export

@article{citeulike:2562889, abstract = {Heritability allows a comparison of the relative importance of genes and environment to the variation of traits within and across populations. The concept of heritability and its definition as an estimable, dimensionless population parameter was introduced by Sewall Wright and Ronald Fisher nearly a century ago. Despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine. Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era.}, author = {Visscher, Peter M. and Hill, William G. and Wray, Naomi R.}, citeulike-article-id = {2562889}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2322}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2322}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18319743}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18319743}, day = {04}, doi = {10.1038/nrg2322}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, month = {March}, number = {4}, pages = {255--266}, posted-at = {2009-09-04 15:12:15}, priority = {2}, publisher = {Nature Publishing Group}, title = {Heritability in the genomics era |[mdash]| concepts and misconceptions}, url = {http://dx.doi.org/10.1038/nrg2322}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2562889 L3 - citeulike-article-id:2562889 N2 - Heritability allows a comparison of the relative importance of genes and environment to the variation of traits within and across populations. The concept of heritability and its definition as an estimable, dimensionless population parameter was introduced by Sewall Wright and Ronald Fisher nearly a century ago. Despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine. Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era. IS - 4 JF - Nature Reviews Genetics SN - 1471-0056 EP - 266 TI - Heritability in the genomics era |[mdash]| concepts and misconceptions PB - Nature Publishing Group VL - 9 SP - 255 AU - Visscher, Peter AU - Hill, William AU - Wray, Naomi PY - 2008/03/04/ UR - http://dx.doi.org/10.1038/nrg2322 ER -