Genetics in geographically structured populations: defining, estimating and interpreting FST Export

@article{citeulike:5467858, abstract = {Wright's F-statistics, and especially F ST, provide important insights into the evolutionary processes that influence the structure of genetic variation within and among populations, and they are among the most widely used descriptive statistics in population and evolutionary genetics. Estimates of F ST can identify regions of the genome that have been the target of selection, and comparisons of F ST from different parts of the genome can provide insights into the demographic history of populations. For these reasons and others, F ST has a central role in population and evolutionary genetics and has wide applications in fields that range from disease association mapping to forensic science. This Review clarifies how F ST is defined, how it should be estimated, how it is related to similar statistics and how estimates of F ST should be interpreted.}, author = {Holsinger, Kent E. and Weir, Bruce S.}, citeulike-article-id = {5467858}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2611}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2611}, day = {01}, doi = {10.1038/nrg2611}, issn = {1471-0056}, journal = {Nat Rev Genet}, month = {September}, number = {9}, pages = {639--650}, posted-at = {2009-09-04 15:05:17}, priority = {2}, publisher = {Nature Publishing Group}, title = {Genetics in geographically structured populations: defining, estimating and interpreting FST}, url = {http://dx.doi.org/10.1038/nrg2611}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5467858 L3 - citeulike-article-id:5467858 N2 - Wright's F-statistics, and especially F ST, provide important insights into the evolutionary processes that influence the structure of genetic variation within and among populations, and they are among the most widely used descriptive statistics in population and evolutionary genetics. Estimates of F ST can identify regions of the genome that have been the target of selection, and comparisons of F ST from different parts of the genome can provide insights into the demographic history of populations. For these reasons and others, F ST has a central role in population and evolutionary genetics and has wide applications in fields that range from disease association mapping to forensic science. This Review clarifies how F ST is defined, how it should be estimated, how it is related to similar statistics and how estimates of F ST should be interpreted. IS - 9 JF - Nat Rev Genet SN - 1471-0056 EP - 650 TI - Genetics in geographically structured populations: defining, estimating and interpreting FST PB - Nature Publishing Group VL - 10 SP - 639 AU - Holsinger, Kent AU - Weir, Bruce PY - 2009/09/01/ UR - http://dx.doi.org/10.1038/nrg2611 ER -