The Genetic Structure and History of Africans and African Americans Export

@article{citeulike:4447374, abstract = {Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (\~{}71\%), European (\~{}13\%), and other African (\~{}8\%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies. 10.1126/science.1172257}, author = {Tishkoff, Sarah A. and Reed, Floyd A. and Friedlaender, Francoise R. and Ehret, Christopher and Ranciaro, Alessia and Froment, Alain and Hirbo, Jibril B. and Awomoyi, Agnes A. and Bodo, Jean-Marie and Doumbo, Ogobara and Ibrahim, Muntaser and Juma, Abdalla T. and Kotze, Maritha J. and Lema, Godfrey and Moore, Jason H. and Mortensen, Holly and Nyambo, Thomas B. and Omar, Sabah A. and Powell, Kweli and Pretorius, Gideon S. and Smith, Michael W. and Thera, Mahamadou A. and Wambebe, Charles and Weber, James L. and Williams, Scott M.}, citeulike-article-id = {4447374}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1172257}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/1172257//}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19407144}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19407144}, day = {22}, doi = {10.1126/science.1172257}, journal = {Science}, keywords = {genetics, humanbiologicalvariation, race}, month = {May}, number = {5930}, pages = {1035--1044}, posted-at = {2009-05-06 14:46:49}, priority = {3}, title = {The Genetic Structure and History of Africans and African Americans}, url = {http://dx.doi.org/10.1126/science.1172257}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4447374 L3 - citeulike-article-id:4447374 N2 - Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (~71%), European (~13%), and other African (~8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies. 10.1126/science.1172257 IS - 5930 JF - Science EP - 1044 TI - The Genetic Structure and History of Africans and African Americans VL - 324 SP - 1035 KW - genetics KW - humanbiologicalvariation KW - race AU - Tishkoff, Sarah AU - Reed, Floyd AU - Friedlaender, Francoise AU - Ehret, Christopher AU - Ranciaro, Alessia AU - Froment, Alain AU - Hirbo, Jibril AU - Awomoyi, Agnes AU - Bodo, Jean-Marie AU - Doumbo, Ogobara AU - Ibrahim, Muntaser AU - Juma, Abdalla AU - Kotze, Maritha AU - Lema, Godfrey AU - Moore, Jason AU - Mortensen, Holly AU - Nyambo, Thomas AU - Omar, Sabah AU - Powell, Kweli AU - Pretorius, Gideon AU - Smith, Michael AU - Thera, Mahamadou AU - Wambebe, Charles AU - Weber, James AU - Williams, Scott PY - 2009/05/22/ UR - http://dx.doi.org/10.1126/science.1172257 ER -