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	Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics, Vol. 5, No. 7. (October 2004), pp. 895-931. by Joseph F. Solus, Brenda J. Arietta, James R. Harris, et al.David P. Sexton, John Q. Steward, Chara McMunn, Patrick Ihrie, Janelle M. Mehall, Todd L. Edwards, Elliott P. Dawson posted by 7 people songpku YinJinJang jjing03 kjkj0001 parkjs80 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract The extent of genetic variation found in drug metabolism genes and its contribution to interindividual variation in response to medication remains incompletely understood. To better determine the identity and frequency of variation in 11 phase I drug metabolism genes, the exons and flanking intronic regions of the cytochrome P450 (CYP) isoenzyme genes CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP3A5 were amplified from genomic DNA and sequenced. A total of 60 kb of bi-directional sequence was generated ...
	Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations. Pharmacogenomics, Vol. 9, No. 2. (February 2008), pp. 169-178. by A. H. Wu, P. Wang, A. Smith, et al.C. Haller, K. Drake, M. Linder, R. Valdes posted by 3 people YinJinJang Asian Pharmacogenetics Library AliceAhn Abstract Copy My Attachments My Copy Abstract OBJECTIVES: Polymorphism in the genes for cytochrome (CYP)2C9 and the vitamin K epoxide reductase complex subunit 1 (VKORC1) affect the pharmacokinetics and pharmacodynamics of warfarin. We developed and validated a warfarin-dosing algorithm for a multi-ethnic population that predicts the best dose for stable anticoagulation, and compared its performance against other regression equations. METHODS: We determined the allele and haplotype frequencies of genes for CYP2C9 and VKORC1 on 167 Caucasian, African-American, Asian and Hispanic patients on warfarin. On a subset where complete ...
	Global pharmacogenetics: genetic substructure of Eurasian populations and its effect on variants of drug-metabolizing enzymes. Pharmacogenomics, Vol. 9, No. 7. (July 2008), pp. 847-868. by Oksana Makeeva, Vadim Stepanov, Valery Puzyrev, David B. Goldstein, Iris Grossman posted by 3 people YinJinJang Asian Pharmacogenetics Library parkjs80 Abstract Copy My Attachments My Copy Abstract AIMS: To study the frequency distribution of cytochrome P450 (CYP) functional genetic variants in five Eurasian populations from the territory of Siberia in Russia. MATERIALS & METHODS: Unrelated healthy Tuvinians, Buryats, Altaians, Yakuts and Russians (n = 87-88) were genotyped for CYP2C92, CYP2C93, CYP2C192, CYP2C193, CYP3A53 and CYP3A56. Standard pairwise genetic distances, locus-specific and global Fst statistics were calculated. RESULTS: CYP allele and genotype frequencies demonstrated significant variability. Overall, the degree of between-population variance displayed by CYP SNPs was lower than ...
	The high prevalence of the poor and ultrarapid metabolite alleles of CYP2D6, CYP2C9, CYP2C19, CYP3A4, and CYP3A5 in Taiwanese population. Journal of human genetics, Vol. 51, No. 10. (19 August 2006), pp. 857-863. by Ya-Huei H. Liou, Chien-Ting T. Lin, Ying-Jye J. Wu, Lawrence Shih-Hsin S. Wu posted by 7 people younghae YinJinJang panwei HwangMiSun HyeEun-Jeong Asian Pharmacogenetics Library parkjs80 Abstract Copy My Attachments My Copy Abstract Genetic polymorphisms of drug metabolizing enzymes, such as cytochromes P450 (CYPs), play major roles in the variations of drug responsiveness in human. The aim of this study is to identify the high prevalence (minor allele frequencies >1%) of the abnormal metabolite alleles of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in the Taiwanese population. The genotyping of the functional single nucleotide polymorphisms (SNPs) of CYPs were conducted by direct exon sequencing in 180 Taiwanese volunteers. Twenty-one unique SNPs including three newly identified ...
	Frequency of cytochrome P450 2C9 allelic variants in the Chinese and French populations. Fundamental & clinical pharmacology, Vol. 17, No. 3. (June 2003), pp. 373-376. by Jue Quin Q. Yang, Sandrine Morin, Céline Verstuyft, et al.Li An A. Fan, Yong Zhang, Chun Di D. Xu, Véronique Barbu, C. Funck-Brentano, Patrice Jaillon, Laurent Becquemont posted by 3 people YinJinJang Asian Pharmacogenetics Library AliceAhn Abstract Copy My Attachments My Copy Abstract Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of different drugs with low therapeutic index such as oral anticoagulants. CYP2C92 and CYP2C93 are two single nucleotide polymorphic allelic variants. The frequency of these alleles in different ethnic populations is extremely variable. In this study, we compared the frequencies of CYP2C9 allelic variants among 394 Chinese living in Shanghai to 151 French Caucasians living in Paris. The allelic frequencies of CYP2C9 variants of the Chinese and the French ...
	Factors affecting the interindividual variability of warfarin dose requirement in adult Korean patients. Pharmacogenomics, Vol. 8, No. 4. (April 2007), pp. 329-337. by Hyun-Jung J. Cho, Kie-Ho H. Sohn, Hyang-Mi M. Park, et al.Kyung-Hoon H. Lee, BoYoung Choi, Seonwoo Kim, June-Soo S. Kim, Young-Keun K. On, Mi-Ryung R. Chun, Hee-Jin J. Kim, Jong-Won W. Kim, Soo-Youn Y. Lee posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract INTRODUCTION: Warfarin, a commonly prescribed anticoagulant, exhibits large interindividual and interethnic differences in the dose required for its anticoagulation effect. Asian patients require a much lower maintenance dose compared with Caucasians; the explanation for these differences remains unknown. METHODS: We analyzed five single nucleotide polymorphisms of the vitamin K epoxide reductase complex subunit 1 gene (VKORC1) and the *3 variant of cytochrome P450 (CYP)2C9, as well as the plasma warfarin concentration, in 108 Korean patients with atrial fibrillation. RESULTS: Genotypic frequencies ...
	Effect of CYP2C9 and VKORC1 genotypes on early-phase and steady-state warfarin dosing in Korean patients with mechanical heart valve replacement. Pharmacogenetics and genomics, Vol. 19, No. 2. (February 2009), pp. 103-112. by H. S. Kim, S. S. Lee, M. Oh, et al.Y. J. Jang, E. Y. Kim, I. Y. Han, K. H. Cho, J. G. Shin posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract OBJECTIVES: The effect of CYP2C9 and vitamin K epoxide reductase complex subunit 1 (VKORC1) genotypes was evaluated for the early-phase and steady-state warfarin dosing in Korean patients with mechanical heart valve replacement. METHODS: The genotypes of CYP2C9 variants including CYP2C93, CYP2C913, and CYP2C9*14, and VKORC1 1173C>T were assessed for the association with warfarin dosing in 265 patients whose data were collected for warfarin dose; international normalized ratio (INR), comedication, comorbidity, and other clinical characteristics. RESULTS: In the early phase of warfarin ...
	Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population. Pharmacogenetics and genomics, Vol. 15, No. 10. (October 2005), pp. 687-691. by David L. Veenstra, Joyce H. You, Mark J. Rieder, et al.Federico M. Farin, Hui-Wen W. Wilkerson, David K. Blough, Gregory Cheng, Allan E. Rettie posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract OBJECTIVE: To evaluate the association of VKORC1 genetic variants with warfarin dose requirements in a Hong Kong Chinese patient population. METHODS: A retrospective study of Hong Kong Chinese patients chronically maintained on warfarin was conducted. Single nucleotide polymorphisms (SNPs) in VKORC1 and CYP2C9 were genotyped. Stable warfarin dose data were retrieved from patient medical records. RESULTS: Sixty-nine patients were included in the analysis. VKORC1 haplotypes H1 (group A) and H7 (group B) were most common, accounting for 86% and 13% of ...
	A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9. Clinical pharmacology and therapeutics, Vol. 80, No. 4. (October 2006), pp. 346-355. by Lai-San S. Tham, Boon-Cher C. Goh, Anne Nafziger, et al.Jia-Yi Y. Guo, Ling-Zhi Z. Wang, Richie Soong, Soo-Chin C. Lee posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract INTRODUCTION: Because of the unique lack of genetic diversity despite the multiethnicity in the Asian population, we hypothesize that single-nucleotide polymorphisms in cytochrome P450 (CYP) 2C9 (CYP2C9*3) and vitamin K epoxide reductase complex subunit 1 (VKORC1) at position 381, used to infer VKORC1haplotype in combination with demographic factors, can accurately predict warfarin doses. The aims of this study were to derive a pharmacogenetics-based dosing algorithm by use of retrospective information and to validate it through a data-splitting method in a separate ...
	Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients. Blood, Vol. 98, No. 8. (15 October 2001), pp. 2584-2587. by A. Y. Leung, H. C. Chow, Y. L. Kwong, et al.A. K. Lie, A. T. Fung, W. H. Chow, A. S. Yip, R. Liang posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract CYP2C9 polymorphisms reported in Caucasians (Arg144Cys in exon 3 and Ile359Leu in exon 7) are extremely uncommon in Chinese persons. The genotype of CYP2C9 in this population was characterized to investigate its relation with the interindividual variation in warfarin dosages. Eighty-nine Chinese patients receiving warfarin were recruited. Target sequences in CYP2C9 in exons 1, 4, and 5 were amplified by polymerase chain reaction, followed by direct sequencing. Polymorphisms at 4 positions were demonstrated in exon 4. Heterozygosities for 608TTG>GTG (Leu208Val), 561CAG>CCG ...
	Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals. Molecular diagnosis & therapy, Vol. 10, No. 1. (2006), pp. 29-40. by E. García-Martín, C. Martínez, J. M. Ladero, J. A. Agúndez posted by 3 people stellarsj Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract Cytochrome P450 (CYP) superfamily members CYP2C8 and CYP2C9 are polymorphically expressed enzymes that are involved in the metabolic inactivation of several drugs, including, among others, antiepileptics, NSAIDs, oral hypoglycemics, and anticoagulants. Many of these drugs have a narrow therapeutic index, and growing evidence indicates a prominent role of CYP2C8 and CYP2C9 polymorphisms in the therapeutic efficacy and in the development of adverse effects among patients treated with drugs that are CYP2C8 or CYP2C9 substrates. In this review, we summarize present knowledge ...
	CYP2C93 allelic variant is associated with metabolism of irbesartan in Chinese population. European journal of clinical pharmacology, Vol. 61, No. 9. (October 2005), pp. 627-634. by X. Hong, S. Zhang, G. Mao, et al.S. Jiang, Y. Zhang, Y. Yu, G. Tang, H. Xing, X. Xu posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract OBJECTIVE: There is considerable variability in the individual pharmaceutical dosages required to achieve optimal therapeutic effects, which may be due to environmental or genetic factors. The objective of this study was to test the presence of the CYP2C93 allelic variant in the Chinese population and to investigate the association of this variant with both metabolism and therapeutic efficacy of irbesartan on essential hypertension. METHODS: In this study, we enrolled 711 subjects from Taihu County and 376 subjects from Dongzhi County in ...
	A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. Human molecular genetics, Vol. 14, No. 13. (1 July 2005), pp. 1745-1751. by H. Y. Yuan, J. J. Chen, M. T. Lee, et al.J. C. Wung, Y. F. Chen, M. J. Charng, M. J. Lu, C. R. Hung, C. Y. Wei, C. H. Chen, J. Y. Wu, Y. T. Chen posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract Warfarin, a commonly prescribed anticoagulant, exhibited large inter-individual and inter-ethnic differences in the dose required for its anticoagulation effect. Asian populations, including Chinese, require a much lower maintenance dose than Caucasians, for which the mechanisms still remain unknown. We determined DNA sequence variants in CYP2C9 and VKORC1 in 16 Chinese patients having warfarin sensitivity (< or = 1.5 mg/day, n = 11) or resistance (> or = 6.0 mg/day, n = 5), 104 randomly selected Chinese patients receiving warfarin, 95 normal ...
	Genetic polymorphism of CYP2C9 in a Vietnamese Kinh population. Therapeutic drug monitoring, Vol. 27, No. 2. (April 2005), pp. 208-210. by S. S. Lee, K. M. Kim, H. Thi-Le, S. S. Yea, I. J. Cha, J. G. Shin posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract Cytochrome P450 2C9 (CYP2C9) shows genetic polymorphism with high interethnic variation, but no report has addressed the genetic polymorphism in the Vietnamese population. In the present study, the distribution of 2 common allelic variations of CYP2C9 was investigated in Vietnamese Kinh population, a major ethnic group in Vietnam. Genomic DNA from 157 Vietnamese subjects was amplified by polymerase chain reaction, and the presence of CYP2C92 and CYP2C93 allelic variants was determined by pyrosequencing. Among 157 Vietnamese subjects, no subject with the ...
	Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics, Vol. 14, No. 8. (August 2004), pp. 527-537. by J. Blaisdell, L. F. Jorge-Nebert, S. Coulter, et al.S. S. Ferguson, S. J. Lee, B. Chanas, T. Xi, H. Mohrenweiser, B. Ghanayem, J. A. Goldstein posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract CYP2C9 is a clinically important enzyme, responsible for the metabolism of numerous clinically important therapeutic drugs. In the present study, we discovered 38 single nucleotide polymorphisms in CYP2C9 by resequencing of genomic DNA from 92 individuals from three different racial groups. Haplotype analysis predicted that there are at least 21 alleles of CYP2C9 in this group of individuals. Six new alleles were identified that contained coding changes: L19I (CYP2C97), R150H (CYP2C98), H251R (CYP2C99), E272G (CYP2C910), R335W(CYP2C911) and P489S (CYP2C912). When expressed ...
	Allele and genotype frequency of CYP2C9 in Tamilnadu population. European journal of clinical pharmacology, Vol. 59, No. 8-9. (November 2003), pp. 707-709. by C. Adithan, N. Gerard, S. Vasu, R. Balakrishnan, C. H. Shashindran, R. Krishnamoorthy posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract OBJECTIVES: To identify the frequency of CYP2C91, 2 and *3 alleles and the genotype of CYP2C9 gene in the Tamilian population. METHODS: The study was conducted on 135 unrelated healthy human volunteers. DNA was extracted from the peripheral leukocytes samples and was analyzed using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) protocol. The PCR products were digested with AvaII, KpnI or NsiI restriction enzymes. The digested products were separated using 8% polyacrylamide gel and stained by ethidium bromide. Genotyping ...
	Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics, Vol. 12, No. 3. (April 2002), pp. 251-263. by C. R. Lee, J. A. Goldstein, J. A. Pieper posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract The discovery of six distinct polymorphisms in the genetic sequence encoding for the cytochrome P450 2C9 (CYP2C9) protein has stimulated numerous investigations in an attempt to characterize their population distribution and metabolic activity. Since the CYP2C91, 2 and 3 alleles were discovered first, they have undergone more thorough investigation than the recently identified 4, 5 and 6 alleles. Population distribution data suggest that the variant 2 and 3 alleles are present in approximately 35% of Caucasian individuals; however, these alleles are ...
	Genetic analysis of CYP2C9 polymorphism in a Japanese population. Pharmacogenetics, Vol. 7, No. 5. (October 1997), pp. 405-409. by K. Nasu, T. Kubota, T. Ishizaki posted by 2 people Asian Pharmacogenetics Library YinJinJang Copy My Attachments My Copy
	Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. The Journal of pharmacology and experimental therapeutics, Vol. 315, No. 3. (December 2005), pp. 1085-1090. by Tracy C. DeLozier, Soo-Chin C. Lee, Sherry J. Coulter, Boon Cher C. Goh, Joyce A. Goldstein posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract CYP2C9 was recently resequenced in 150 Asian subjects from Singapore. Several new coding variants were reported, and these variants are now named CYP2C914 (R125H), CYP2C915 (S162X), CYP2C916 (T299A), CYP2C917 (P382S), CYP2C918 (D397A), and CYP2C919 (Q454H). The CYP2C918 variant also contained an I359L change previously associated with the CYP2C93 allele. In this study, we assessed the functional consequences of the new coding changes. cDNAs containing each of the new coding changes were constructed by site-directed mutagenesis and expressed in a bacterial cDNA ...
	Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. Pharmacogenetics and genomics, Vol. 19, No. 5. (May 2009), pp. 345-352. by X. Tang, S. Guo, H. Sun, et al.X. Song, Z. Jiang, L. Sheng, D. Zhou, Y. Hu, D. Chen posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract OBJECTIVES: Nicotine is the major psychoactive ingredient in tobacco, and is responsible for dependence through the nicotine-stimulated reward pathway mediated by the central dopaminergic system. Consequently, genetic polymorphisms in both nicotine metabolism and dopamine catabolism genes may influence smoking behavior, and interact with each other resulting in risk modulation. In this study, we investigated the association and multilocus gene-gene interactions of cytochrome P450 2A6 (CYP2A6), dopamine beta-hydroxylase (DBH), catechol O-methyl transferase (COMT), and monoamine oxidase A (MAOA) polymorphisms with smoking behavior ...
	Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. Pharmacogenetics and genomics, Vol. 15, No. 2. (February 2005), pp. 105-113. by S. S. Lee, H. E. Jeong, K. H. Liu, et al.J. Y. Ryu, T. Moon, C. N. Yoon, S. J. Oh, C. H. Yun, J. G. Shin posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract CYP2J2 plays important roles in the metabolism of therapeutic drugs, such as astemizole and ebastine, as well as endogenous fatty acids. This study aimed to identify CYP2J2 genetic variants in Koreans and to characterize their functional consequences. From direct sequencing of the CYP2J2 gene, 12 genetic variations, including the two novel nonsynonymous mutations G312R and P351L, were identified from 93 Korean subjects. The two novel CYP2J2 variants were co-expressed with NADPH-cytochrome P450 reductase in Sf9 cells and their catalytic activities were ...
	Genetic factors contribute to patient-specific warfarin dose for Han Chinese. Clinica chimica acta; international journal of clinical chemistry, Vol. 396, No. 1-2. (October 2008), pp. 76-79. by T. L. Wang, H. L. Li, W. Y. Tjong, et al.Q. S. Chen, G. S. Wu, H. T. Zhu, Z. S. Hou, S. Xu, S. J. Ma, M. Wu, S. Tai posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract BACKGROUND: Warfarin is a commonly prescribed anticoagulant drug for the prevention of thromboses. To address the association of genetic factors and warfarin dosage for ethnic Han Chinese, we genotyped six candidate genes involved in the warfarin interactive pathway with focus on SNPs with reported association with warfarin dose. METHODS: We recruited a study population consisted of 318 patients receiving warfarin treatment and 995 healthy controls. PCR and direct sequencing were used to identify the sequence polymorphisms. RESULTS: In our study population, ...
	CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese. Clinica chimica acta; international journal of clinical chemistry, Vol. 367, No. 1-2. (May 2006), pp. 108-113. by Herng-Der D. Chern, Tzuu-Huei H. Ueng, Yi-Ping P. Fu, Chun-Wen W. Cheng posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract BACKGROUND: Warfarin prevents thromboembolism in patients with prosthetic heart valvular replacement. Cytochrome P4502C9 (CYP2C9) is polymorphic in human and is principally responsible for the metabolism of warfarin. However, known CYP2C9 polymorphisms cannot entirely account for the low dose requirement of warfarin in Chinese-Taiwanese receiving mitral valve replacement. We screened a new polymorphism of CYP2C9 and investigated its role in warfarin sensitivity. METHODS: We examined warfarin dose requirements in 239 Chinese-Taiwanese patients who had attended a cardiac surgery clinic in National Taiwan ...
	Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam. European journal of clinical pharmacology, Vol. 65, No. 4. (1 April 2009), pp. 355-363. by M. I. Veiga, S. Asimus, P. E. Ferreira, et al.J. P. Martins, I. Cavaco, V. Ribeiro, T. N. Hai, M. G. Petzold, A. Björkman, M. Ashton, J. P. Gil posted by 10 people younghae lullaby ilsun HyeEun-Jeong macosiol panwei parkjs80 SuJeongLim Asian Pharmacogenetics Library zzangleehyok Abstract Copy My Attachments My Copy Abstract AIM: The aim of this study was to obtain pharmacogenetic data in a Vietnamese population on genes coding for proteins involved in the elimination of drugs currently used for the treatment of malaria and human immunodeficiency virus/acquired immunodeficiency syndrome. METHOD: The main polymorphisms on the cytochrome P450 (CYP) genes, CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4 and CYP3A5, and the multi-drug resistance 1 gene (MDR1) were genotyped in 78 healthy Vietnamese subjects. Pharmacokinetic metrics were available for CYP2A6 (coumarin), CYP2C19 (mephenytoin), CYP2D6 (metoprolol) ...
	Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis. Cell biochemistry and function, Vol. 26, No. 3. (April 2008), pp. 309-313. by B. Ercan, L. Ayaz, D. Ciçek, L. Tamer posted by 3 people parkjs80 Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract The arachidonic acid metabolizing CYP enzymes with prominent roles in vascular regulation are epoxygenases of the two gene family which generate epoxyeicosatrienoic acids. Carriers of CYP2C9 mutant alleles exhibit a diminished CYP2C9 metabolic capacity leading to decreased endothelium-derived hyperpolarizing factors (EDHF) synthesis and an increased risk for atherosclerosis. We investigated whether the polymorphisms of CYP2C9/19 are related with atherosclerosis. We examined 108 patients having angioraphically > or =70 coronary artery narrowing and 90 healthy controls. CYPC2C9/192 and CYP2C9/193 alleles were investigated ...
	Gender specific association of CYP2C93 with hyperlipidaemia in Chinese. British journal of clinical pharmacology, Vol. 60, No. 6. (December 2005), pp. 629-631. by C. H. Luo, A. Wang, R. H. Zhu, et al.W. X. Zhang, W. Mo, B. N. Yu, G. L. Chen, D. S. Ou-Yang, X. H. Duan, A. M. Abd El-Aty, H. H. Zhou posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract AIMS: To investigate the association of CYP2C93 and 6 with hyperlipidaemia in Chinese. METHODS: Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C93 and 6. RESULTS: CYP2C96 was not detected in this study. The allelic frequency of CYP2C93 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C93 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients ...
	The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers. Journal of clinical pharmacy and therapeutics, Vol. 33, No. 1. (February 2008), pp. 67-73. by T. Uno, K. Sugimoto, K. Sugawara, T. Tateishi posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract The aim of this study was to elucidate the pharmacokinetics and pharmacodynamics of warfarin enantiomers in relation to cytochrome P450 2C19 (CYP2C19) genotypes.Fourteen subjects, of whom seven were homozygous extensive metabolizers (hmEMs) and seven were poor metabolizers (PMs) for CYP2C19, were enrolled. After a single oral 10 mg dose of racemic warfarin, the plasma concentrations of the warfarin enantiomers and prothrombin time expressed as international normalized ratio (PT-INR) were measured over the course of 120 h.The mean plasma concentrations and elimination ...
	The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics. Clinical pharmacokinetics, Vol. 44, No. 11. (2005), pp. 1179-1189. by Y. Ishizawa, N. Yasui-Furukori, T. Takahata, M. Sasaki, T. Tateishi posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND AND OBJECTIVE: The metabolic activity of cytochrome P450 (CYP) 2C19 is genetically determined, and the pharmacokinetics of omeprazole, a substrate for CYP2C19, are dependent on the CYP2C19 genotype. However, a discrepancy between the CYP2C19 genotype and omeprazole pharmacokinetics was reported in patients with liver disease or advanced cancer. The objective of the present study was to evaluate the effect of aging on the relationship between the CYP2C19 genotype and its phenotype. METHODS: Twenty-eight elderly and 23 young Japanese volunteers were ...
	Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison. Cancer letters, Vol. 213, No. 2. (30 September 2004), pp. 195-202. by Alireza Sepehr, Farin Kamangar, Christian C. Abnet, et al.Saman Fahimi, Akram Pourshams, Hossein Poustchi, Sirous Zeinali, Masood Sotoudeh, Farhad Islami, Dariush Nasrollahzadeh, Reza Malekzadeh, Philip R. Taylor, Sanford M. Dawsey posted by 4 people jjing03 carore Asian Pharmacogenetics Library kimminji Abstract Copy My Attachments My Copy Abstract The age-standardized incidence of esophageal cancer (EC) varies from 3 to >100/100,000 per year in different provinces of Iran. This striking variation of incidence is associated with differences in ethnic backgrounds, raising the possibility that genetic factors are involved in the pathogenesis of EC. We compared the frequencies of polymorphisms in ten genes that have been hypothesized to have a role in risk of EC (CYP1A1, CYP2A6, CYP2E1, GSTM1, GSTP1, GSTT1, ADH2, ADH3, ALDH2, and O6-MGMT) among three Iranian ethnic groups ...
	Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Alimentary pharmacology & therapeutics, Vol. 26, No. 5. (1 September 2007), pp. 693-703. by T. Furuta, M. Sugimoto, N. Shirai, et al.F. Matsushita, H. Nakajima, J. Kumagai, K. Senoo, C. Kodaira, M. Nishino, M. Yamade, M. Ikuma, H. Watanabe, K. Umemura, T. Ishizaki, A. Hishida posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND: Polymorphism in MDR1 is associated with variation in the plasma level of a proton pump inhibitor. AIM: To investigate whether MDR1 polymorphism is associated with eradication rates of Helicobacter pylori by a triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP2C19 genotype status and bacterial susceptibility to clarithromycin. METHODS: A total of 313 patients infected with H. pylori completed the treatment with lansoprazole 30 mg b.d., clarithromycin 200 mg b.d. and amoxicillin 750 mg b.d. for 1 week. ...
	CYP2C19 polymorphism affects personality traits of Japanese females. Neuroscience letters, Vol. 411, No. 1. (3 January 2007), pp. 77-80. by G. Ishii, A. Suzuki, S. Oshino, H. Shiraishi, K. Otani posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract It has been suggested that personality traits are heritable. The polymorphic cytochrome P450 (CYP) 2C19 metabolizes sex hormones and 5-hydroxytryptamine, which are involved in multiple brain functions. In the present study, the relationship between the CYP2C19 polymorphism and personality traits was examined in 487 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character Inventory (TCI), and the two mutated alleles causing absent CYP2C19 activity were identified by a PCR-RFLP method. In females, the scores of reward dependence (p=0.026), ...
	The association between genetic polymorphisms in CYP19 and breast cancer risk in Korean women. Oncology reports, Vol. 22, No. 3. (September 2009), pp. 487-492. by Ji Young Y. Kim, Chang Suk S. Lee, Hye Ok O. Kim, et al.Yong Hwa H. Jo, Juhie Lee, Min Hyung H. Jung, Hyung Hwan H. Baik, Wonchae Choe, Insug Kang, Kyung-Sik S. Yoon posted by 3 people Mi-Seon Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Aromatase encoding by the CYP19 gene catalyzes the conversion of androgens to estrogens. In order to determine if polymorphisms of the CYP19 gene are associated with breast cancer risk, we analyzed the frequency of tetranucleotide (TTTA) tandem repeats and a 3-bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene in genomic DNA from 70 Korean breast cancer patients and 102 age-matched, healthy women. The 3-bp deletion allele was found more frequently in the breast cancer group than in ...
	[Cytochrome P450 2C19 genotype -based second line therapy with amoxicillin and lansoprazole after failure of initial helicobacter pylori eradication therapy] Nippon rinsho. Japanese journal of clinical medicine, Vol. 63 Suppl 12 (December 2005), pp. 450-453. by M. Asano, H. Taniwaki, D. Tsuji, Y. Sato, T. Shimizu posted by 2 people Asian Pharmacogenetics Library ilsun Copy My Attachments My Copy
	[Influence of cytochrome P450 2C19 genetic polymorphism on H. pylori eradication therapy] Nippon rinsho. Japanese journal of clinical medicine, Vol. 63 Suppl 11 (November 2005), pp. 569-572. by T. Hikichi, A. Irisawa, C. Abe, K. Obara, Y. Sato posted by 2 people Asian Pharmacogenetics Library ilsun Copy My Attachments My Copy
	Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection. Alimentary pharmacology & therapeutics, Vol. 22, No. 10. (15 November 2005), pp. 1033-1040. by M. Sugimoto, T. Furuta, N. Shirai, et al.A. Nakamura, M. Kajimura, H. Sugimura, A. Hishida, T. Ishizaki posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND: Cytochrome P450 2C19 (CYP2C19) polymorphism has been associated with the development of lung, liver or oesophageal cancer by detoxification of carcinogen(s) or activation of procarcinogen(s). AIM: To clarify the association between CYP2C19 polymorphisms and gastric cancer development in Japanese. Methods : We determined CYP2C19 genotypes (CYP2C191, 2 and *3) in 111 Helicobacter pylori-positive patients with gastric cancer and 315 H. pylori-positive controls without gastric cancer consisting of patients with gastritis only or peptic ulcer. Frequencies of CYP2C19 genotypes and serum ...
	Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers. Clinical pharmacology and therapeutics, Vol. 65, No. 6. (June 1999), pp. 606-614. by J. W. Ko, I. J. Jang, J. G. Shin, S. K. Nam, S. G. Shin, D. A. Flockhart posted by 4 people kjkj0001 parkjs80 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Lansoprazole is a potent gastric proton pump inhibitor that is metabolized by CYP2C19 but appears to induce the activity of hepatic microsomal CYP1A2 in a concentration-dependent manner. Because the inducing effect appears to be a dose-dependent phenomenon, it may be more important in poor metabolizers of CYP2C19 who have more than four times the area under the lansoprazole plasma concentration-time curve (AUC) and constitute 12% to 23% of Asian populations. Theophylline owes a significant portion of its metabolism to CYP1A2 and ...
	High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands. Pharmacogenetics, Vol. 9, No. 5. (October 1999), pp. 581-590. by A. Kaneko, J. K. Lum, L. Yaviong, et al.N. Takahashi, T. Ishizaki, L. Bertilsson, T. Kobayakawa, A. Björkman posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Cytochrome P450 (CYP) 2C19 is polymorphic with poor metabolizers representing 3-6% of Europeans and Africans, and 13-23% of Asians. Greater than 99% of the poor metabolizer alleles in Asian populations are defined by two single base pair mutations (CYP2C192 and CYP2C193). We have recently reported an unprecedentedly high prevalence (71%) of CYP2C19-related poor metabolizer genotype individuals and poor metabolism of proguanil on two malarious islands of Vanuatu in eastern Melanesia. To elucidate this further, a total of 5538 individuals from 24 ...
	Genetic polymorphisms and esophageal cancer risk. International journal of cancer. Journal international du cancer, Vol. 121, No. 8. (15 October 2007), pp. 1643-1658. by Toru Hiyama, Masaharu Yoshihara, Shinji Tanaka, Kazuaki Chayama posted by 3 people jjing03 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract The aim of this paper is to review and evaluate, in a comprehensive manner, the published data regarding the contribution of genetic polymorphisms to risk of esophageal cancer, including squamous cell carcinoma (SCC) and adenocarcinoma, in humans. All relevant studies available in MEDLINE and published before February 2007 were identified. Studies carried out in humans and that compared esophageal cancer patients with at least 1 standard control group were considered for analysis. One-hundred studies and 3 meta-analyses were identified. Eighty (80%) ...
	Pharmacogenetic roles of CYP2C19 and CYP2B6 in the metabolism of R- and S-mephobarbital in humans. Pharmacogenetics, Vol. 14, No. 8. (August 2004), pp. 549-556. by K. Kobayashi, J. Morita, K. Chiba, et al.A. Wanibuchi, M. Kimura, S. Irie, A. Urae, T. Ishizaki posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract OBJECTIVES AND METHODS: We assessed the relationship between the metabolism of R- and S-mephobarbital (MPB) and genetic polymorphisms of cytochrome P450 (CYP) 2C19 and CYP2B6. Nine homozygous extensive metabolizers (homo-EMs, 2C191/2C191) of CYP2C19, ten heterozygous EMs (hetero-EMs, 2C191/2C192, 2C191/2C193) and eleven poor metabolizers (PMs, 2C192/2C192, 2C193/2C193, 2C192/2C193) recruited from a Japanese population, received an oral 200 mg-dose of racemic MPB. Blood and urine samples were collected, and R-MPB, S-MPB and the metabolites, phenobarbital (PB) and 4'-hydroxy-MPB, were measured. Each subject was ...
	The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. The Science of the total environment, Vol. 381, No. 1-3. (1 August 2007), pp. 38-46. by Bo Chen, Yunping Hu, Taiyi Jin, et al.Daru Lu, Minhua Shao, Lixing Zheng, Qiangyi Wang, Yue Shen, Hongliang Liu, Yanhong Liu, Yuanfen Zhou posted by 3 people jjing03 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Urinary 1-hydroxypyrene (1-OHP), a biomarker of polycyclic aromatic hydrocarbons (PAHs) exposure, may be influenced by metabolic gene polymorphisms. Such knowledge could benefit us in understanding the inter-individual difference in the mechanism of PAHs-induced carcinogenesis. We investigated the influence of gene polymorphisms on urinary 1-OHP concentrations in 447 coke oven workers from two coking plants in south China. After adjustment for age, plant, level of occupational exposure, body mass index, level of education, alcohol consumption, cigarette smoking and respirator usage, AhR R554K ...
	Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. The pharmacogenomics journal, Vol. aop, No. current. (28 July 2009) by Q. Zhou, X. M. Yu, H. B. Lin, et al.L. Wang, Q. Z. Yun, S. N. Hu, D-M M. Wang posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract The cytochrome P450 2C19 and 2D6 enzymes are predominantly found in the human liver, and have important functions in the metabolism of many different classes of commonly used drugs. Their genetic polymorphisms give rise to both important interethnic variability in metabolism and the risk of treatment failure or dose-dependent drug toxicity. To investigate genetic polymorphisms in CYP2C19 and CYP2D6 genes in Han Chinese, we sequenced regions of the 5' flanking region, exon, intron and 3' UTR from these two genes using ...
	Novel mutations in the cytochrome P450 2C19 gene: a pitfall of the PCR-RFLP method for identifying a common mutation. Journal of human genetics, Vol. 51, No. 2. (2006), pp. 118-123. by Y. Ohkubo, A. Ueta, N. Ando, et al.T. Ito, S. Yamaguchi, K. Mizuno, S. Sumi, T. Maeda, D. Yamazaki, Y. Kurono, S. Fujimoto, H. Togari posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract CYP2C19 is a clinically important enzyme involved in the metabolism of therapeutic drugs such as (S)-mephenytoin, omeprazole, proguanil, and diazepam. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM) on the basis of CYP2C19 enzyme activity. The PM phenotype occurs in 2-5% of Caucasian populations, but at higher frequencies (18-23%) in Asians. CYP2C192 and CYP2C193, which are single-nucleotide polymorphisms of CYP2C19, are the main cause of PM phenotyping in homozygotes or compound heterozygotes. We report two novel ...
	A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation. Drug metabolism and pharmacokinetics, Vol. 19, No. 3. (June 2004), pp. 236-238. by J. Morita, K. Kobayashi, A. Wanibuchi, et al.M. Kimura, S. Irie, T. Ishizaki, K. Chiba posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract We sequenced all nine exons and exon-intron junctions of the cytochrome P450 2C19 (CYP2C19) gene from a Japanese subject with a lowered capacity of CYP2C19-mediated 4'-hydroxylation after an oral administration of mephobarbital. We found a novel single nucleotide polymorphism (SNP) of CYP2C19 gene as follows: SNP, 040110MoritaJ001; GENENAME: CYP2C19; ACCESSION NUMBER: NT_030059.8; LENGTH; 25 bases; 5'-GAGGGCCTGGCCC/TGCATGGAGCTGT-3'. The SNP (168946C>T) induced an amino acid alteration (Arg442Cys) located in exon 9 close to the heme-binding region of CYP2C19, which may result in the ...
	[Interluekin-1 beta genetic polymorphism influences the impact of cytochrome P 2C19 genotype on the cure rate of H. pylori eradication therapy] Nippon rinsho. Japanese journal of clinical medicine, Vol. 62, No. 3. (March 2004), pp. 455-458. by M. Mizuno, S. Take, K. Ishiki, H. Okada, Y. Shiratori posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Genetic polymorphism of interleukin(IL)-1 beta is associated with differences in gastric acid suppression in response to H. pylori infection. Thus, the polymorphism might affect H. pylori eradication therapy since antibiotics used in treatment regimens may be acid-sensitive. We examined the impact of IL-1 beta genetic polymorphism on the cure rate of triple therapy for H. pylori in relation to cytochrome P(CYP)2C19 genotype. In the normal acid-secretion IL-1 beta genotype group, the cure rate among CYP2C19 poor metabolizers was significantly higher than ...
	[Genetic polymorphisms of the CYP450 1A1, CYP450 2E1, GSTM1, GSTT1, and GSTP1 in Korean] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, Vol. 22, No. 3. (June 2005), pp. 347-349. by Qing-song S. Xu, Yun-Chul C. Hong, Kuan-Hee H. Lee posted by 3 people jjing03 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract OBJECTIVE: This is an investigation on the polymorphism distribution of genes related with metabolism, such as cytochrome P450 1A1 (CYP1A1), CYP2E1, glutathione S-transferase M1 (GSTM1), GSTT1 and GSTP1 among the Korean public. METHODS: The techniques of polymerase chain reaction-restriction fragment length polymorphism were adopted. The authors analyzed the polymorphisms for 3-flanking region of CYP1A1 gene by the restriction endonuclease MspI, for 5-flanking region of the gene of CYP2E1 by PstI, for GSTP1 by BsmAI, and for the presence of GSTM1 and ...
	Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer. BMC cancer, Vol. 7 (30 June 2007), 115. by Chunhong Fan, Mingjuan Jin, Kun Chen, Yongjing Zhang, Shuangshuang Zhang, Bing Liu posted by 3 people jjing03 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract BACKGROUND: Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC). METHODS: A case-only design was conducted in a Chinese population including 207 patients with sporadic CRC. Unconditional logistic regression analysis was performed adjusting for age, gender, alcohol consumption, and cigarette smoking. RESULTS: The interaction odds ratio (COR) for ...
	Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole), amoxycillin and clarithromycin in Japan. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, Vol. 33, No. 8. (November 2001), pp. 671-675. by M. Dojo, T. Azuma, T. Saito, M. Ohtani, A. Muramatsu, M. Kuriyama posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND: Omeprazole is mainly metabolized by cytochrome P450 2C19 (CYP2C19) in the liver. Rabeprazole, on the other hand, is mainly metabolized to thioether-rabeprazole via a non-enzymatic pathway and partially metabolized to demethylated-rabeprazole by CYP2C19 in liver CYP2C19 status may affect cure rate for Helicobacter pylori infection with proton pump inhibitor triple therapy. AIM: To investigate whether genetic polymorphism of CYP2C19 and selected proton pump inhibitors (omeprazole or rabeprazole) were associated with cure rate for Helicobacter pylori infection using triple therapy with ...
	Cytochrome P450 2C19 polymorphism influences the preventive effect of lansoprazole on the recurrence of erosive reflux esophagitis. Journal of gastroenterology and hepatology, Vol. 22, No. 2. (February 2007), pp. 222-226. by M. Kawamura, S. Ohara, T. Koike, et al.K. Iijima, H. Suzuki, S. Kayaba, K. Noguchi, S. Abe, M. Noguchi, T. Shimosegawa posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND: The efficacy of lansoprazole (LPZ) at inhibiting gastric acid secretion is influenced by cytochrome P450 2C19 (CYP2C19) polymorphism. The purpose of the present study was to investigate whether CYP2C19 polymorphism had an influence on the remission of erosive reflux esophagitis (RE) during maintenance therapy with LPZ. METHODS: Eighty-two Japanese patients with initial healing of erosive RE by 8 weeks of LPZ therapy were enrolled. As maintenance therapy, the patients were treated with LPZ (15 mg/day) for 6 months. The CYP2C19 ...
	Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patients. Drug metabolism and disposition: the biological fate of chemicals, Vol. 37, No. 4. (April 2009), pp. 821-826. by K. Hosohata, S. Masuda, T. Katsura, et al.Y. Takada, T. Kaido, Y. Ogura, F. Oike, H. Egawa, S. Uemoto, K. Inui posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract To assess the effects of intestinal cytochrome P450 2C19 on the interaction between tacrolimus and proton pump inhibitors, we examined the concentration/dose ratio [(ng/ml)/(mg/day)] of tacrolimus coadministered with omeprazole (20 mg) or lansoprazole (30 mg) to 89 adult living-donor liver transplant patients on postoperative days 22 to 28, considering the CYP2C19 genotypes of the native intestine and the graft liver, separately. The concentration/dose ratio of tacrolimus coadministered with omeprazole was significantly higher in patients with two variants (2 or 3) for ...
	Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers. Journal of gastroenterology, Vol. 34 Suppl 11 (1999), pp. 80-83. by N. Aoyama, Y. Tanigawara, T. Kita, et al.T. Sakai, K. Shirakawa, D. Shirasaka, F. Kodama, K. Okumura, M. Kasuga posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Omeprazole is widely used for the treatment of Helicobacter pylori infection. It is metabolized by cytochrome P450 2C19 enzyme (CYP2C19) in the liver. Because this enzyme exhibits a genetic polymorphism, patients with low metabolic activity (poor metabolizers) may be exposed to higher concentrations of this drug than are patients who are extensive metabolizers. Eighty-six patients with cultured H. pylori-positive gastritis or peptic ulcers who completed the treatment and assessment of anti-H. pylori therapy were analyzed for CYP2C19 genotyping using a polymerase ...
	A rapid and simple detection of genetic defects responsible for the phenotypic polymorphism of cytochrome P450 2C19. Biological & pharmaceutical bulletin, Vol. 22, No. 1. (January 1999), pp. 77-79. by K. Itoh, K. Inoue, S. Yanagiwara, H. Kyoya, T. Suzuki posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract A rapid and simple cytochrome P450 (CYP) 2C19 genotyping system was established by making several modifications in previously reported procedures. PCR conditions were modified to be capable of simultaneous amplification of CYP2C19m1 and CYP2C19m2 regions. Intensive bands of 169 bp for the CYP2C19m1 region and 329 bp for the CYP2C19m2 region with low background were obtained by using PCR condition involving an initial denaturation of 5 min at 94 degrees C, 35 cycles of 1 min at 94 degrees C; 1 ...
	High-dose rabeprazole-amoxicillin versus rabeprazole-amoxicillin-metronidazole as second-line treatment after failure of the Japanese standard regimen for Helicobacter pylori infection. Alimentary pharmacology & therapeutics, Vol. 18, No. 1. (1 July 2003), pp. 101-107. by H. Isomoto, K. Inoue, H. Furusu, et al.A. Enjoji, C. Fujimoto, M. Yamakawa, Y. Hirakata, K. Omagari, Y. Mizuta, K. Murase, S. Shimada, I. Murata, S. Kohno posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND: There is currently no optimal second-line treatment after failure of Helicobacter pylori triple therapy. AIM: To determine effective salvage therapy after failure of lansoprazole-amoxicillin-clarithromycin. METHODS: After failure of lansoprazole-amoxicillin-clarithromycin 123 out-patients were randomized to receive either 2-week rabeprazole (20 mg b.d.) + amoxicillin (1000 mg b.d.) (RA group) or 1-week rabeprazole (10 mg b.d.) + amoxicillin (750 mg twice b.d.) + metronidazole (250 mg b.d.) (RAM group). Eradication was assessed by the 13C-urea breath test. We also evaluated cytochrome p450 ...
	Association of polymorphisms in the cytochrome P450 (CYP) 2C19 and 2C18 genes in Japanese epileptic patients. Pharmacogenetics, Vol. 8, No. 1. (February 1998), pp. 87-90. by K. Mamiya, I. Ieiri, S. Miyahara, et al.J. Imai, H. Furuumi, Y. Fukumaki, H. Ninomiya, N. Tashiro, H. Yamada, S. Higuchi posted by 2 people Asian Pharmacogenetics Library ilsun Copy My Attachments My Copy
	Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene. Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 26, No. 4. (August 2003), pp. 337-342. by Ryukichi Kumashiro, Takahiro Kubota, Yuriko Koga, et al.Masatoshi Tanaka, Chizuko Inada, Nobuhide Kusaba, Hiroshi Yoshida, Akiko Hisamochi, Tatsuya Ide, Yuko Tomita, Naoko Masumoto, Kyuichi Tanikawa, Tatsuji Iga, Michio Sata posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract An anti-diabetic agent, troglitazone, was withdrawn from the market because of its association with liver injury. However, the mechanism of the injury has not been elucidated. We examined, retrospectively, the frequency of the polymorphisms of the cytochrome P450 (CYP) 2C19 and 2D6 genes in eight patients with type 2 diabetes who had troglitazone-induced liver injury and 31 subjects who tolerated troglitazone well. Polymorphisms of CYP 2C19 and 2D6 genes were analyzed by polymerase chain reaction using peripheral white blood cells. The ...
	Genetic polymorphisms and cancer susceptibility of breast cancer in Korean women. Journal of biochemistry and molecular biology, Vol. 36, No. 1. (31 January 2003), pp. 28-34. by Daehee Kang posted by 3 people jjing03 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Breast cancer is the most prevalent cancer among women in Western countries, and its prevalence is also increasing in Asia. The major risk factor for breast cancer can be traced to reproductive events that influence the lifetime levels of hormones. However, a large percentage of breast cancer cases cannot, be explained by these risk factors. The identification of susceptibility factors that predispose individuals to breast cancer (for instance, if they are exposed to particular environmental agents) could possibly give further insight ...
	Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology, Vol. 21, No. 1-2. (r 2000), pp. 101-111. by D. L. Eaton posted by 3 people jjing03 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Numerous specific genetic polymorphisms (PM) in the multi-gene families of cytochromes P450 (CYPs) and glutathione S-transferases (GSTs) have been described in the human population in the past decade. For example, one or more PM have been identified in human CYP1A1, CYP1B1, CYP2C9, CYP2C18, CYP2D6, and CYP2E1. Recent studies using cDNA expressed human CYPs have suggested that CYP3A4 is the principal human CYP involved in the oxidation of parathion and probably other organo(thio)phosphate (OP) insecticides and thus PM in this CYP might ...
	The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism. Alimentary pharmacology & therapeutics, Vol. 17, No. 7. (1 April 2003), pp. 965-973. by M. Kawamura, S. Ohara, T. Koike, et al.K. Iijima, J. Suzuki, S. Kayaba, K. Noguchi, S. Hamada, M. Noguchi, T. Shimosegawa, posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND: The acid suppressive effect of lansoprazole is influenced by the P450 2C19 (CYP2C19) polymorphism. AIM: To investigate whether the CYP2C19 genotype is related to the healing of erosive reflux oesophagitis during treatment with lansoprazole. METHODS: Eighty-eight Japanese patients with erosive reflux oesophagitis were treated with a daily oral dose of 30 mg lansoprazole for 8 weeks. The CYP2C19 genotype, Helicobacter pylori infection status and serum pepsinogen I/II ratio were assessed before treatment. At 4 and 8 weeks, the healing of ...
	The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics, Vol. 6, No. 4. (August 1996), pp. 341-349. by T. H. Sullivan-Klose, B. I. Ghanayem, D. A. Bell, et al.Z. Y. Zhang, L. S. Kaminsky, G. M. Shenfield, J. O. Miners, D. J. Birkett, J. A. Goldstein posted by 2 people Asian Pharmacogenetics Library YinJinJang Abstract Copy My Attachments My Copy Abstract Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for this metabolism is thought to be CYP2C9. Population studies have indicated the existence of slow metabolizers of tolbutamide (approximately 1 in 500) suggesting a rare polymorphism associated with 2C9. Several allelic variants of 2C9 have been identified; however, the effect of these allelic variations on metabolism in vivo is not established. In the present study, the coding regions, intron-exon junctions, and upstream region of CYP2C9 ...
	Pharmacogenomics of proton pump inhibitors. Pharmacogenomics, Vol. 5, No. 2. (March 2004), pp. 181-202. by T. Furuta, N. Shirai, M. Sugimoto, K. Ohashi, T. Ishizaki posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Proton pump inhibitors (PPIs), such as omeprazole, lansoprazole, rabeprazole, esomeprazole, and pantoprazole, are metabolized by cytochrome P450 isoenzyme 2C19 (CYP2C19) in the liver. There are genetic differences that affect the activity of this enzyme. The genotypes of CYP2C19 are classified into three groups: homozygous extensive metabolizer (homEM), heterozygous extensive metabolizer (hetEM), and poor metabolizer (PM). The pharmacokinetics and pharmacodynamics of PPIs differ among the different CYP2C19 genotype groups. Plasma PPI and intragastric pH levels during PPI treatment are the lowest in ...
	Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations. The Journal of pharmacy and pharmacology, Vol. 56, No. 8. (August 2004), pp. 1055-1059. by F. Itagaki, M. Homma, K. Yuzawa, et al.M. Nishimura, S. Naito, N. Ueda, N. Ohkohchi, Y. Kohda posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract The aim of this study was to investigate the effects of the proton pump inhibitors (PPIs), lansoprazole and rabeprazole, on tacrolimus pharmacokinetics in healthy volunteers with mutations in the cytochrome P450 (CYP) 2C19 gene (CYP2C19). An open-label crossover study was performed with 19 healthy subjects. Tacrolimus (2 mg) was administered orally with and without lansoprazole (30 mg per day for 4 days) or rabeprazole (10 mg per day for 4 days). Blood concentrations of tacrolimus were determined before and 1, 2, ...
	Correlation between voriconazole trough plasma concentration and hepatotoxicity in patients with different CYP2C19 genotypes. International journal of antimicrobial agents, Vol. 34, No. 1. (July 2009), pp. 91-94. by Kazuaki Matsumoto, Kazuro Ikawa, Kazuko Abematsu, et al.Naoko Fukunaga, Kentaro Nishida, Tomohide Fukamizu, Yoshihiro Shimodozono, Norifumi Morikawa, Yasuo Takeda, Katsushi Yamada posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Voriconazole metabolism is mostly mediated via the cytochrome P450 (CYP) 2C19 isozyme. The non-wild (mutant) type of CYP2C19 is generally found in 60-70% of Asian populations. Because the voriconazole trough plasma concentration has been reported to correlate with hepatotoxicity, this study investigated the effect of CYP2C19 polymorphism on the relationship between voriconazole trough concentrations and liver function abnormalities in 29 Japanese patients with fungal infections (CYP2C19 wild-type, n=10; non-wild-type, n=19). Hepatotoxicity, defined as liver enzyme abnormality according to the National Cancer ...
	[Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China.] Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, Vol. 26, No. 5. (September 2004), pp. 584-588. by Ge-Yu Y. Liang, Yue-Pu P. Pu, Li-Hong H. Yin posted by 4 people jjing03 carore Asian Pharmacogenetics Library kimminji Abstract Copy My Attachments My Copy Abstract To investigate the genes related to lung cancer susceptibility in Nanjing Han population, China, a 1:1 matched case-control study was performed in which 152 hospital controls were matched to the 152 original lung cancer cases. The polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, mEH and NQO1 genes were analyzed by PCRjRFLP assay. The results showed that the heterozygote and mutation homozygote genotypes of CYP1A1 were related to the risk of squamous cell carcinoma (OR=2.31, 95%CI=1.23-4.36). The risk of suffering from lung ...
	Comparison of an increased dosage regimen of rabeprazole versus a concomitant dosage regimen of famotidine with rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotypes. Clinical pharmacology and therapeutics, Vol. 77, No. 4. (April 2005), pp. 302-311. by M. Sugimoto, T. Furuta, N. Shirai, et al.A. Nakamura, M. Kajimura, A. Hishida, K. Ohashi, T. Ishizaki posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND AND OBJECTIVE: A concomitant dosage regimen of a histamine 2 receptor antagonist with a proton pump inhibitor (PPI) effectively decreases the incidence of nocturnal acid breakthrough, which is one of the problems encountered when acid-related diseases are treated with a PPI alone. We compared the effectiveness of an increased dosage regimen of rabeprazole with that of a concomitant dosage regimen of rabeprazole with famotidine, relative to cytochrome P450 (CYP) 2C19 genotype status, on nocturnal acid inhibition. METHODS: Fifteen Helicobacter pylori-negative ...
	Randomized open trial for comparison of proton pump inhibitors in triple therapy for Helicobacter pylori infection in relation to CYP2C19 genotype. Journal of gastroenterology and hepatology, Vol. 17, No. 7. (July 2002), pp. 748-753. by T. Inaba, M. Mizuno, K. Kawai, et al.K. Yokota, K. Oguma, M. Miyoshi, S. Take, H. Okada, T. Tsuji posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract BACKGROUND AND AIMS: Genetic polymorphism of cytochrome P450 (CYP) 2C19 influences the efficacy of Helicobacter pylori eradication therapy with a proton pump inhibitor (PPI) and amoxicillin. However, in triple therapy (PPI plus amoxicillin and clarithromycin), little is known about the impact of CYP2C19 polymorphism, or the use of rabeprazole, which is not well metabolized by CYP2C19. The efficacy of three PPI (omeprazole, lansoprazole, and rabeprazole) in a 1-week triple regimen were compared in relation to CYP2C19 polymorphism. METHOD: One hundred and ...
	Polymerase chain reaction-single-strand conformation polymorphism based determination of two major genetic defects responsible for a phenotypic polymorphism of cytochrome P450 (CYP) 2C19 in the Japanese population. Analytical biochemistry, Vol. 284, No. 1. (15 August 2000), pp. 160-162. by K. Itoh, K. Inoue, H. Nakao, S. Yanagiwara, H. Tada, T. Suzuki posted by 2 people Asian Pharmacogenetics Library ilsun Copy My Attachments My Copy
	Association between cytochrome P450 (CYP) 2C19 polymorphisms and harm avoidance in Japanese. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 144B, No. 6. (5 September 2007), pp. 724-727. by Norio Yasui-Furukori, Ayako Kaneda, Kumiko Iwashima, et al.Manabu Saito, Taku Nakagami, Shoko Tsuchimine, Sunao Kaneko posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Polymorphic enzyme cytochrome P450 (CYP) 2C19 is expressed not only in the liver but also in the brain and mediates the biotransformation of 5-hydroxytriptamine (5-HT). We investigated possible association between genetic polymorphism of CYP2C19 and individual personality traits, possibly influenced by neurotransmitters. Mentally and physically healthy Japanese subjects were enrolled in this study (n = 352). Temperament and Character Inventory (TCI) and CYP2C19 genotyping were performed in all subjects. We detected CYP2C192 and 3 (http://www.imm.ki.se/CYPalleles/) using Amplichip CYP450 DNA tip. The ...
	Different dosage regimens of rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotype status. Clinical pharmacology and therapeutics, Vol. 76, No. 4. (October 2004), pp. 290-301. by M. Sugimoto, T. Furuta, N. Shirai, et al.M. Kajimura, A. Hishida, M. Sakurai, K. Ohashi, T. Ishizaki posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract OBJECTIVE: For the treatment of gastroesophageal reflux disease, intragastric pH should be lower than 4.0 for no more than 4 hours a day (<16.7%). We aimed to develop optimal dosage regimens for rabeprazole to control nocturnal acidity in relation to cytochrome P450 (CYP) 2C19 genotypes. METHODS: Fifteen Helicobacter pylori -negative volunteers, comprising 5 homozygous extensive metabolizers (EMs), 6 heterozygous EMs, and 4 poor metabolizers (PMs) of CYP2C19, took placebo and rabeprazole, at a dose of 20 or 40 mg once daily ...
	Functional characterization of two novel CYP2C19 variants (CYP2C1918 and CYP2C1919) found in a Japanese population. Xenobiotica; the fate of foreign compounds in biological systems, Vol. 37, No. 4. (April 2007), pp. 342-355. by N. Hanioka, Y. Tsuneto, Y. Saito, et al.T. Sumada, K. Maekawa, K. Saito, J. Sawada, S. Narimatsu posted by 2 people Asian Pharmacogenetics Library ilsun Abstract Copy My Attachments My Copy Abstract Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism of a wide range of therapeutic drugs and exhibits genetic polymorphism with interindividual differences in metabolic activity. We have previously described two CYP2C19 allelic variants, namely CYP2C1918 and CYP2C1919 with Arg329His/Ile331Val and Ser51Gly/Ile331Val substitutions, respectively. In order to investigate precisely the effect of amino acid substitutions on CYP2C19 function, CYP2C19 proteins of the wild-type (CYP2C19.1B having Ile331Val) and variants (CYP2C19.18 and CYP2C19.19) were heterologously expressed in yeast cells, and their ...
	Genetic polymorphisms in the cytochrome P450 1A1 and 2E1 genes, smoking, drinking and prostate cancer susceptibility: a case-control study in a Han nationality population in Southern China. International journal of urology : official journal of the Japanese Urological Association, Vol. 13, No. 6. (June 2006), pp. 773-780. by Jie Yang, Li-Xin X. Qian, Hong-Fei F. Wu, et al.Zheng-Quan Q. Xu, Yuan-Geng G. Sui, Xin-Ru R. Wang, Wei Zhang posted by 3 people jjing03 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract AIM: To investigate the association among the polymorphisms of the cytochrome P450 1A1 and 2E1 genes, smoking, drinking and the risk of prostate cancer (PCa) in a Han nationality population in Southern China. METHODS: A case-control study including 225 PCa patients and 250 age-matched controls was conducted. The six polymorphic sites of the CYP 1A1 and CYP2E1 genes were analysed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) or allele-specific PCR technique using genomic DNA isolated from peripheral blood lymphocytes. ...
	Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population. European journal of clinical pharmacology, Vol. 59, No. 4. (August 2003), pp. 303-312. by Elena A. Gaikovitch, Ingolf Cascorbi, Przemyslaw M. Mrozikiewicz, et al.Jürgen Brockmöller, Roland Frötschl, Karla Köpke, Thomas Gerloff, Jury N. Chernov, Ivar Roots posted by 3 people parkjs80 Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract OBJECTIVE: The frequency of functionally important mutations and alleles of genes coding for xenobiotic metabolizing enzymes shows a wide ethnic variation. However, little is known of the frequency distribution of the major allelic variants in the Russian population. METHODS: Using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) genotyping assays and the real-time PCR with fluorescent probes, the frequencies of functionally important variants of the cytochromes P450 (CYP) 2C9, 2C19, 2D6, 1A1 as well as arylamine N-acetyltransferase 2 (NAT2) and P-glycoprotein (MDR1) ...
	Association study between functional polymorphisms in the cytochrome P450 1A2 and 2D6 genes and polydipsia in schizophrenia. Neuromolecular medicine, Vol. 8, No. 3. (2006), pp. 381-388. by C. Matsumoto, T. Shinkai, V. De Luca, et al.H. Hori, R. Hwang, O. Ohmori, J. L. Kennedy, J. Nakamura posted by 3 people Asian Pharmacogenetics Library carore AliceAhn Abstract Copy My Attachments My Copy Abstract The underlying pathophysiology of polydipsia in schizophrenia is poorly understood. Several studies, however, have suggested that there might be a genetic predisposition to polydipsia. In the present study, using a case-control sample that is independent from the previous family sample, we examined a possible association between polydipsia and functional polymorphisms in the genes of cytochrome P450 (CYP) 1A2 and 2D6, primarily important enzymes to the pharmacokinetics of antipsychotic drugs. Japanese patients with schizophrenia (63 polydipsics and 78 nonpolydipsics) were genotyped for ...
	Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Clinica chimica acta; international journal of clinical chemistry, Vol. 382, No. 1-2. (July 2007), pp. 37-42. by Ehtesham Arif, Arpana Vibhuti, Pervez Alam, et al.Desh Deepak, Bhawani Singh, Mohammad Athar, Qadar A. Pasha posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract BACKGROUND: Detoxification genes are potential candidates in the susceptibility of patients with chronic obstructive pulmonary disease. Polymorphisms in these genes alter the metabolism of xenobiotics such as present in cigarette smoke. METHODS: We conducted a case-control study to investigate total 9 polymorphisms of CYP2E1, CYP2D6 and NAT2 genes by PCR-RFLP. RESULTS: The -1053C/T and -1293G/C promoter polymorphisms of CYP2E1 were found to be in complete linkage disequilibrium (LD) (D'=1.00, r(2)=1.0, p<0.0001), whereas -1293G/C and 7632T/A polymorphisms of the same gene were ...
	Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese. Drug metabolism and disposition: the biological fate of chemicals, Vol. 27, No. 1. (January 1999), pp. 98-101. by J. D. Huang, W. C. Guo, M. D. Lai, Y. L. Guo, G. H. Lambert posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Despite a wide interindividual variation of cytochrome P-450 1A2 (CYP1A2) activity, genetic polymorphism of CYP1A2 has not been reported. By amplification of exons of CYP1A2 by polymerase chain reaction in eight Chinese subjects, the polymerase chain reaction products were directly sequenced. One subject showed heterozygous C2866-->G (Phe21-->Leu) polymorphism. DNA from 157 Chinese subjects (104 polychlorinated biphenyl-exposed subjects and 53 control subjects) was screened for polymorphism by single-strand conformation polymorphism method and MboII endonuclease digestion. Only 1 of 157 samples showed another ...
	Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease. Mutation research, Vol. 667, No. 1-2. (10 July 2009), pp. 77-81. by Chih-Ching C. Yeh, Fung-Chang C. Sung, Li-Tang T. Kuo, Wan-Ping P. Hsu, Hsiang-Yu Y. Chu posted by 3 people carore Asian Pharmacogenetics Library kimminji Abstract Copy My Attachments My Copy Abstract Epidemiological evidence has demonstrated a strong relationship between cigarette smoking and coronary artery disease (CAD). Cytochrome P450 1A1 (CYP1A1) is a key enzyme that metabolizes the cigarette toxin relevant to smoking-induced atherogenesis. This case-control study examined the role of CYP1A1 polymorphisms, CYP1A12A (T6235C) and CYP1A12C (A4889G), in susceptibility to smoking-related CAD. We recruited 481 patients with 50% or more luminal obstructions in the coronary artery and 228 normal subjects at a medical center in Taiwan. Information on socio-demographic and smoking status ...
	Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese. Clinical biochemistry, Vol. 40, No. 12. (August 2007), pp. 881-886. by Yasuo Tsuchiya, Chikako Kiyohara, Toyoji Sato, Kazutoshi Nakamura, Akira Kimura, Masaharu Yamamoto posted by 3 people carore Asian Pharmacogenetics Library kimminji Abstract Copy My Attachments My Copy Abstract OBJECTIVES: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. DESIGN AND METHODS: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. RESULTS: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism ...
	Phenotype of cytochrome P4501B1 gene (CYP1B1) mutations in Japanese patients with primary congenital glaucoma. The British journal of ophthalmology, Vol. 87, No. 3. (March 2003), pp. 302-304. by Y. Ohtake, T. Tanino, Y. Suzuki, et al.H. Miyata, M. Taomoto, N. Azuma, H. Tanihara, M. Araie, Y. Mashima posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract AIM: To investigate the phenotypes associated with cytochrome P4501B1 gene (CYP1B1) mutations in Japanese patients with primary congenital glaucoma (PCG). METHODS: 66 Japanese patients with PCG were screened for sequence mutations in the CYP1B1 gene using single strand conformation polymorphism analysis followed by automated DNA sequencing. 11 cases had a CYP1B1 mutation in both alleles (the mutation group) and 21 cases did not have a CYP1B1 mutation (the "no mutation" group). The clinical features, such as age of onset, sex, intraocular ...
	CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians. Pharmacogenomics, Vol. 9, No. 5. (May 2008), pp. 551-560. by S. S. Soya, T. Vinod, K. S. Reddy, S. Gopalakrishnan, C. Adithan posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract INTRODUCTION: The CYP2E1 enzyme is responsible for the metabolic activation of several procarcinogens into reactive metabolites that result in carcinogenesis. The genetic polymorphisms that modify these enzymatic activities may be associated with upper aerodigestive tract cancer risk. METHODS: This hospital-based study evaluated CYP2E11B, CYP2E15B and CYP2E1*6 polymorphisms in 408 histopathologically confirmed cases and 220 population-based controls using PCR-RFLP methods. RESULTS: The multivariate logistic regression analyses demonstrated no significant differences between groups for all three polymorphisms when analyzed separately. However, the gene-environment ...
	Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis. Immunology letters, Vol. 90, No. 2-3. (15 December 2003), pp. 151-154. by Jeng-Hsien H. Yen, Wen-Chun C. Tsai, Chia-Hui H. Lin, Tsan-Teng T. Ou, Chaur-Jong J. Hu, Hong-Wen W. Liu posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract To investigate the role of cytochrome P450 1A1 (CYP1A1) and manganese superoxide dismutase (Mn SOD) genes polymorphisms in the susceptibility to reactive arthritis, the polymorphisms of CYP1A1 and Mn SOD genes were determined in 43 patients with reactive arthritis following Chlamydia trachomatis infection and 92 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) method. The frequencies of CYP1A1 4887C/A and C/A+A/A were significantly higher in patients with reactive arthritis than in controls. Moreover, the increased frequency of CYP1A1 ...
	Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. European journal of clinical pharmacology, Vol. 62, No. 8. (August 2006), pp. 627-631. by Y. Yoon, H. D. Park, K. U. Park, J. Q. Kim, Y. S. Chang, J. Song posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract OBJECTIVE: Theophylline is metabolized to 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine, and 1-methylxanthine by CYP1A2 and partly by CYP2E1. Because 1,3-DMU is the major metabolite of theophylline, the 1,3-DMU/theophylline ratio is viewed as a good indicator of theophylline metabolic clearance. Here, we investigated the associations between 1,3-DMU/theophylline ratios and genetic polymorphisms of CYP2E1 and CYP1A2. METHODS: Polymerase chain reaction (PCR) and direct sequencing or PCR-restriction fragment length polymorphism (RFLP) were performed to analyze CYP2E1 and CYP1A2 promoter polymorphisms in 62 Korean asthma patients. ...
	Variable drug metabolism genes in Arab population. The pharmacogenomics journal, Vol. 4, No. 4. (2004), pp. 260-266. by R. Bu, M. I. Gutiérrez, M. Al-Rasheed, A. Belgaumi, K. Bhatia posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Cataloging interethnic differences in the distribution of genotypes of drug metabolic genes provides valuable information for profiling the pharmacogenetics of a population. We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO1 in Arabs. The frequencies of alleles and/or genotypes for CYP1A12A, GSTT1 null, GSTT1 and GSTM1 double null, and GSTP1 A1578G in Arabs were significantly higher than those reported in Caucasians. However, the distribution of NAT2 acetylator phenotypes in ...
	Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus. Immunology letters, Vol. 90, No. 1. (15 November 2003), pp. 19-24. by Jeng-Hsien H. Yen, Chung-Jen J. Chen, Wen-Chun C. Tsai, et al.Chia-Hui H. Lin, Tsan-Teng T. Ou, Chaur-Jong J. Hu, Hong-Wen W. Liu posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract OBJECTIVES: To investigate the role of cytochrome P450 1A1 (CYP1A1) and manganese superoxide dismutase (Mn SOD) genes polymorphisms in the pathogenesis of systemic lupus erythematosus (SLE) in Taiwan. METHODS: CYP1A1 and Mn SOD genes polymorphisms were determined by the polymerase chain reaction/restriction fragment length polymorphism (RFLP) method in 90 patients with SLE and 94 healthy controls. RESULTS: The genotype frequency of CYP1A1 4887C/A was significantly higher in patients with SLE than in controls. The allele and phenotype frequencies of CYP1A1 4887A ...
	Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking. Molecular and cellular biochemistry, Vol. 322, No. 1-2. (February 2009), pp. 73-79. by Munish Kumar, Sudhir K. Agarwal, Sudhir K. Goel posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Lung cancer (LC) is the leading cause of cancer-related mortality in developing as well as developed countries. Life style choices, particularly tobacco smoking, have been implicated as the main cause in the development of the LC. Despite the fact that majority cases of the LC occur among smokers, only 1-15% of smokers develop LC. In the present study, we have explored the role of genetic polymorphism, smoking habit and their association to LC in a cohort of north Indian population. The ...
	Frequencies of four genetic polymorphisms in the CYP1A2 gene in Turkish population. Genetika, Vol. 44, No. 8. (August 2008), pp. 1133-1136. by T. Bilgen, O. Tosun, G. Luleci, I. Keser posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Cytochrome P450 (CYP) 1A2 gene is involved in the metabolic activation of several carcinogens and altered metabolization of some clinically used drugs. We aimed to investigate the distributions of genetic polymorphisms -3860 (G/A)(CYP1A21C) and -2467 (T/del)(CYP1A21D) in the 5'-flanking region and -739 (T/G)(CYP1A21E) and -163(C/A)(CYP1A21F) in the first intron of the CYP1A2 gene in 110 unrelated healthy Turkish volunteers by PCR-RFLP technique. The frequencies of each polymorphism in Turkish population were found as 0.04, 0.92, 0.01, 0.27 for CYP1A21C, CYP1A21D, CYP1A2*1E, ...
	CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia. Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology, Vol. 138, No. 1-2. (12 January 2008), pp. 12-17. by Mehmet Taspinar, Sena Erdogan E. Aydos, Omer Comez, Atilla Halil H. Elhan, Halil Gurhan G. Karabulut, Asuman Sunguroglu posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract PRINCIPLES: Associations between polymorphisms for genes encoding enzymes involved in biotransformation of xenobiotics and susceptibility to several cancers have been shown in several studies. The aim of the present study is to investigate the influence of cytochromes P450 (CYP450) 1A1*2C and Glutathione S-transferases (GSTs) (T1 and M1) gene polymorphisms in susceptibility to chronic myeloid leukaemia (CML). METHODS: The frequency of CYP1A1 Ile/Val alleles and of GSTT1 and GSTM1 homozygous deletions was examined in 107 patients with CML and 132 healthy controls ...
	[Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], Vol. 38, No. 3. (May 2004), pp. 162-166. by Wei-ping P. Yu, Kun Chen, Xin-yuan Y. Ma, et al.Kai-yan Y. Yao, Qin-ting T. Jiang, Yan Zou, Hai-guang G. Zhou posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract OBJECTIVE: To investigate PstI allelic variants of cytochrome P450 2E1 (CYP2E1), the interaction effect on salted food and their role in risk for colorectal cancer. METHODS: The genotypes of CYP2E1 PstI restriction fragment length polymorphism were analyzed in 126 colorectal cancer cases and 343 normal controls. The unconditional logistic regression was applied to estimate the OR and its 95% CI. RESULTS: The CYP2E1 C1/C1, C1/C2 and C2/C2 genotypes were found respectively in 61.8%, 35.8% and 2.4% of normal control, similar to ...
	Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer. Journal of gastroenterology, Vol. 39, No. 3. (2004), pp. 220-230. by Shioto Suzuki, Youko Muroishi, Isao Nakanishi, Yoshio Oda posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract BACKGROUND: Genetic polymorphisms of drug-metabolizing enzymes have recently been shown to affect susceptibility to chemical carcinogenesis. However, the molecular mechanisms of individual susceptibility to gastric cancer have not been fully understood. Therefore, we studied the relationship between the genetic polymorphisms of drug-metabolizing enzymes, drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer. METHODS: The genotypes of cytochromes P450 ( CYP) 1A1 and 2E1, glutathione S-transferase ( GST) M1, and N-acetyltransferase ( NAT) were investigated by ...
	GST genetic polymorphisms and lung adenocarcinoma susceptibility in a Chinese population. Cancer letters, Vol. 201, No. 2. (25 November 2003), pp. 185-193. by Jingwen Wang, Yifu Deng, Jinglei Cheng, Jianmin Ding, Shinkan Tokudome posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract Lung adenocarcinoma (AC) has been increasing over the last several decades in many countries, including China. Some of the glutathione S-transferases (GSTs) demonstrate polymorphisms which may play a role in lung AC susceptibility. Our previous study of a Chinese population found the GSTM1 null genotype to be associated with an increased risk of lung AC, and the combination of GSTM1 null genotype and CYP2E1 wild type conferred a significantly elevated risk. Here, we extended the study to investigate the potential role ...
	Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans. Journal of gastroenterology and hepatology, Vol. 18, No. 11. (November 2003), pp. 1257-1263. by Geun Tae T. Park, Oh Young Y. Lee, Sung Joon J. Kwon, et al.Chun Geun G. Lee, Byung Chul C. Yoon, Joon Soo S. Hahm, Min Ho H. Lee, Dong Hoo Lee, Choon Suhk S. Kee, Hee Sik S. Sun posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract BACKGROUND: Interindividual genetic differences in susceptibility to chemical carcinogens are among the most important host factors in human cancer. The present study was undertaken to reveal the association between the polymorphism of CYP2E1 (CYP2E1/PstI and CYP2E1/DraI) with genetic susceptibility to gastric cancer development in Koreans. METHODS: In the present study, 120 gastric cancer patients and 145 controls with no history of tumors were analyzed. CYP2E1 was determined by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP), or PCR and direct gel electrophoresis. ...
	Polymorphisms of CYP1A1, GSTM1, GSTT1, and prostate cancer risk in Turkish population. Cancer investigation, Vol. 24, No. 1. (February 2006), pp. 41-45. by Yavuz Silig, Hatice Pinarbasi, Sezgin Günes, Semih Ayan, Hasan Bagci, Oge Cetinkaya posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract Prostate cancer is the most common cancer among men in many countries. Although the etiology of prostate cancer largely is unknown, both genetic and environmental factors may be involved. Advanced age, androgen metabolism, and heredity-race have been reported to be possible risk factors. On the other hand, several studies indicate that genetic polymorphisms in biotransformation enzymes play a role in prostate cancer development. In this study, association of the prostate cancer risk with genotype frequencies of the Phase I (CYP1A1) and ...
	Polymorphisms of metabolic enzyme genes, living habits and prostate cancer susceptibility. Frontiers in bioscience : a journal and virtual library, Vol. 11 (2006), pp. 2052-2060. by Jie Yang, Hong-fei F. Wu, Wei Zhang, et al.Min Gu, Li-xin X. Hua, Yuan-geng G. Sui, Zheng-dong D. Zhang, Jian-wei W. Zhou, Xin-Ru R. Wang, Changping Zou, Li-xin X. Qian posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract In this report, genetic polymorphism of phase I and II metabolic enzyme (CYP2E1, CYP17, GSTM1 and GSTT1) genes, living habits, and risk of prostate cancer (PCa) was studied in 163 patients with prostate carcinoma of Han nationality in Southern China and 202 age-matched controls. The genotypic polymorphism of CYP2E1, CYP17, GSTM1 and GSTT1 genes was analyzed by PCR-RFLP assay using genomic DNA isolated from peripheral blood lymphocytes. The significant risk factors for PCa included long-term exposure to toxicant (OR=2.27, 95%CI: 1.26-4.09), ...
	Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users. Cancer letters, Vol. 195, No. 1. (30 May 2003), pp. 33-42. by Nilabja Sikdar, Sk Abdul A. Mahmud, Ranjan Rashmi R. Paul, Bidyut Roy posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract Inter-individual genetic differences may contribute to differences in susceptibility to human diseases triggered by environmental exposures. In this study, we investigated polymorphisms at two sites in the CYP1A1 and three sites in the CYP2E1 genes in 99 leukoplakia patients and 227 controls from one Indian population. The frequencies of genotypes at these polymorphic sites (MspI and Ileu/Val) in the CYP1A1 and (PstI, RsaI and DraI) in the CYP2E1 genes, were similar in patient and control groups. But the combined rare and ...
	Genetic susceptibility for emphysematous changes of the lung in Japanese. International journal of molecular medicine, Vol. 11, No. 3. (March 2003), pp. 321-329. by Antariksa Budhi, Keiko Hiyama, Takeshi Isobe, et al.Yoshie Oshima, Hitoshi Hara, Hiroyuki Maeda, Nobuoki Kohno posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract Risk of chronic pulmonary emphysema from exposure to tobacco smoke varies widely from person to person, depending in part on the status of particular genes and acquired susceptibilities. Certain genes determine how cells activate and/or detoxify tobacco smoke products. We aimed to determine whether any genetic susceptibility exists in the development of emphysematous changes confirmed by chest computed tomography (CT). Genotypes of various enzymes involved in the activation or detoxification of tobacco smoke, epoxide hydrolase (EPHX1), cytochrome P450s (CYP1A1 and CYP2E1), ...
	Evaluation in vinyl chloride monomer-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes. World journal of gastroenterology : WJG, Vol. 11, No. 37. (7 October 2005), pp. 5821-5827. by Shou-Min M. Zhu, Xue-Feng F. Ren, Jun-Xiang X. Wan, Zhao-Lin L. Xia posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract AIM: To analyze occupational health hazards exposure to doses lower than the Chinese occupational health standard in a selected VC polymerization plant in China, and also to elucidate the relationship between genetic polymorphisms and genetic susceptibility on liver lesions of workers exposed to vinyl chloride monomer(VCM). METHODS: In order to explore the mechanism of VCM-related health effects, we used a case-control design to investigate the association between the genetic polymorphisms of metabolic enzymes and liver lesions in workers occupationally exposed to ...
	Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers. Journal of human hypertension, Vol. 16, No. 7. (July 2002), pp. 479-486. by Y. Yamada, F. Sun, I. Tsuritani, R. Honda posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract Orientals have unique genetic polymorphisms in ethanol metabolizing enzymes, such as alcohol dehydrogenase-2 (ADH2), aldehyde dehydrogenase-2 (ALDH2) and cytochrome P450-2E1 (CYP2E1). Of the three studies conducted to clarify the influence of ALDH2 genotypes on sensitivity to the pressor effects of alcohol in Japanese, only one was suggested, though indirectly, higher sensitivity in drinkers having the genotype of inactive ALDH2. This discrepancy prompted us to determine ADH2, ALDH2 and CYP2E1 genotypes in the genomic DNA extracted from white blood cells of 855 ...
	Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 11, No. 1. (January 2002), pp. 29-34. by Changming Gao, Toshiro Takezaki, Jianzhong Wu, et al.Zhongyou Li, Jiandong Wang, Jianhua Ding, Yanting Liu, Xu Hu, Tianliang Xu, Kazuo Tajima, Haruhiko Sugimura posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract Because cytochrome P-450 2E1 (CYP2E1) is involved in metabolic activation of environmental chemical carcinogens, gene polymorphisms that alter its functions may be associated with cancer susceptibility. However, previous studies have revealed disconcordant results with regard to cancer risk. To investigate gene-environment interactions with the RsaI polymorphism of CYP2E1 in terms of risk of esophageal and stomach cancers, we conducted a case-control study with 93 esophageal and 98 stomach cancer cases and 196 population-based controls in a high-endemic area for these cancers ...
	A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population. Oncology reports, Vol. 14, No. 4. (October 2005), pp. 919-923. by Toshihiko Iizasa, Masayuki Baba, Yukio Saitoh, et al.Makoto Suzuki, Yukiko Haga, Akira Iyoda, Hao Chang, Kenzo Hiroshima, Sakae Itoga, Takeshi Tomonaga, Fumio Nomura, Takehiko Fujisawa posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract Cytochrome P450 2E1 (CYP2E1) catalyzes the metabolic activation of the procarcinogen, N-nitrosodimethylamine, and cytotoxic carbon tetrachloride compounds. A tandem repeat polymorphism in the 5'-flanking region of the CYP2E1 gene was investigated in non-small cell lung carcinoma (NSCLC) patients to clarify the relationship between CYP2E1 gene polymorphism and lung cancer susceptibility. Blood samples were taken from 236 healthy control subjects (192 males and 44 females) and 111 patients (78 males and 33 females) who underwent surgery for NSCLC in Japan. DNA was ...
	Genetic polymorphism of drug metabolizing enzymes (CYP2E1, GSTP1) and susceptibility to bladder cancer in North India. Asian Pacific journal of cancer prevention : APJCP, Vol. 6, No. 1. (r 2005), pp. 6-9. by Rama D. Mittal, Daya Shankar S. Srivastava, Mandhani A, Mittal B posted by 2 people Asian Pharmacogenetics Library jjing03 Abstract Copy My Attachments My Copy Abstract Glutathione-S-transferases (GSTs) are active in the detoxification of wide variety of endogenous or exogenous carcinogens and genetic polymorphisms of CYP2E1 and GSTP1 genes have been studied extensively to evaluate the relative risk of various cancers. In the present study, we examined associations with CYP2E1 and GSTP1 gene polymorphisms in sporadic bladder cancers from North Indian patients. The subjects were 106 bladder cancer (Ca-B) cases and 162 age-matched controls. The GSTP1 313 A/G polymorphism was determined by the PCR/RFLP method using peripheral ...
	The relationship between the response of clinical symptoms and plasma olanzapine concentration, based on pharmacogenetics: Juntendo University Schizophrenia Projects (JUSP). Therapeutic drug monitoring, Vol. 30, No. 1. (February 2008), pp. 35-40. by M. Nozawa, T. Ohnuma, Y. Matsubara, et al.Y. Sakai, T. Hatano, R. Hanzawa, N. Shibata, H. Arai posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract The monitoring of plasma olanzapine concentrations has been found to be an important and useful tool for optimizing psychiatric treatment. The present study investigated the effect that clinical factors, such as smoking and age, and functional polymorphisms of UGT1A4, CYP1A2, and CYP2D6 genes have on plasma olanzapine concentration, as well as the effects of plasma olanzapine concentrations on Japanese schizophrenic patients' clinical symptoms. The subjects included 51 chronic schizophrenic patients whose symptoms were not controlled with chronic conventional antipsychotics and therefore ...
	CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 16, No. 3. (June 2006), pp. 1407-1411. by I. Esinler, D. Aktas, M. Alikasifoglu, E. Tuncbilek, A. Ayhan posted by 2 people Asian Pharmacogenetics Library carore Abstract Copy My Attachments My Copy Abstract The cytochrome P4501A1 (CYP1A1) is involved in the metabolism of environmental carcinogens and estrogen. We hypothesized that CYP1A1 genetic polymorphism may be a susceptibility factor for endometrial hyperplasia (EH) and endometrial carcinoma (ECa). We therefore evaluated this hypothesis in patients with EH and ECa and control subjects using allele-specific polymerase chain reaction-based method in a Turkish population. The patients with CYP1A1 Ile/Val genotype had a fivefold higher risk of having EH than those with Ile/Ile. In contrast, a higher frequency of ...
	Metabolic gene polymorphisms and lung cancer risk in non-smokersAn update of the GSEC study Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 592, No. 1-2. (30 December 2005), pp. 45-57. by S. Raimondi, P. Boffetta, S. Anttila, et al.J. Brockmoller, D. Butkiewicz, I. Cascorbi, M. Clapper, T. Dragani, S. Garte, A. Gsur posted by 3 people Asian Pharmacogenetics Library carore risch Abstract Copy My Attachments My Copy Abstract Since genetic factors may play an important role in lung cancer development at low dose carcinogen exposure, non-smokers are a good model to study genetic susceptibility and its interaction with environmental factors. We evaluated the role of the metabolic gene polymorphisms CYP1A1MspI , CYP1A1Ile 462 Val , GSTM1 , and GSTT1 in non-smoker lung cancer patients from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). Non-smokers (defined as subjects who never smoked on ...

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