guhjy's profile

About me

Username:	guhjy
Name:	Jinn-Yuh Guh
Job title:	Not specified
Affiliation:	Not specified
Web page:	Not specified
Joined:	2004-11-28

What I do

Not specified

Interests

diabetic nephropathy

Recent Activity

2009-11-20

10:43: posted Obesity and impaired renal function: potential for lifestyle intervention?
10:38: posted The causes, prevalence and treatment of obesity revisited in 2009: what have we learned so far?
10:38: posted Exercise and diet in weight management: updating what works.
10:38: posted A review and meta-analysis of the effect of weight loss on all-cause mortality risk.
10:37: posted The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation.
10:35: posted Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.
10:28: posted Implantable cardioverter defibrillator therapy in chronic kidney disease: a meta-analysis.
02:48: posted Blood pressure level and kidney disease progression: do we really need to go to 130/80 mm Hg?
02:46: posted Effect of vitamin D on blood pressure: a systematic review and meta-analysis.
02:44: posted Exercise therapy in type 2 diabetes.
02:44: posted Blood pressure changes associated with sibutramine and weight management - an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes trial (SCOUT).
02:40: posted Systematic review of long-term lifestyle interventions to prevent weight gain and morbidity in adults.
02:39: posted Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose.
02:37: posted The role of Mediterranean type of diet on the development of cancer and cardiovascular disease, in the elderly: A systematic review.
02:28: posted WITHDRAWN: Dieting to reduce body weight for controlling hypertension in adults.
02:28: posted A critical review of the cannabinoid receptor as a drug target for obesity management.
02:28: posted Weight and blood pressure response to weight management and sibutramine in diabetic and non-diabetic high-risk patients: an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes (SCOUT) trial.
02:23: posted Weight change, initial BMI, and mortality among middle- and older-aged adults.
02:22: posted Interpreting weight losses from lifestyle modification trials: using categorical data.
02:20: posted Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy.
02:18: posted Treatment modalities of obesity: what fits whom?
02:18: posted Is weight loss beneficial for reduction of morbidity and mortality? What is the controversy about?
02:12: posted Obesity in the elderly diabetic patient: is weight loss beneficial? No.
02:11: posted Obesity, proteinuria and progression of renal failure.
02:09: posted Weight loss and proteinuria.
02:07: posted Prolonged Administration Enhances the Renoprotective Effect of Pentoxifylline via Anti-Inflammatory Activity in Streptozotocin-Induced Diabetic Nephropathy.
02:07: posted Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer
01:55: posted Polyunsaturated fatty acids and cardiovascular disease.
01:53: posted Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetes.
01:50: posted Approach to the patient with possible Cushing's syndrome.
01:45: posted Sodium Glucose Cotransporter 2 Inhibitors as a New Treatment for Diabetes Mellitus.
01:44: posted Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.
01:43: posted Review article: importance of the kidney proximal tubular cells in thiazolidinedione-mediated sodium and water uptake.
01:42: posted The physiological impact of the serum and glucocorticoid-inducible kinase SGK1.
01:39: posted Role of bile acids and bile acid receptors in metabolic regulation.
01:39: posted FARNESOID X RECEPTOR MODULATES RENAL LIPID METABOLISM AND DIET-INDUCED RENAL INFLAMMATION, FIBROSIS, AND PROTEINURIA.
01:37: posted Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy.
01:36: posted Targeting heme oxygenase: therapeutic implications for diseases of the cardiovascular system.
01:36: posted Heme oxygenase-1: from biology to therapeutic potential.
01:36: posted The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure.
01:34: posted Heme oxygenase: the key to renal function regulation.

2009-11-19

2009-11-18

15:14: posted Glycyrrhetinic acid food supplementation lowers serum potassium concentration in chronic hemodialysis patients
15:13: posted A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney disease
15:13: posted The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification
15:09: posted Chapter 1: Introduction and definition of CKD|[ndash]|MBD and the development of the guideline statements
15:07: posted Effects of hemodialysis on cardiac function
15:04: posted Diagnostic methods 2: receiver operating characteristic (ROC) curves
15:04: posted Initiation of dialysis at higher GFRs: is the apparent rising tide of early dialysis harmful or helpful|[quest]|
15:04: posted Immunoregulatory role of TNF|[alpha]| in inflammatory kidney diseases
15:04: posted Genome-wide linkage analysis of serum creatinine in three isolated European populations
15:03: posted Aliskiren: a novel renoprotective agent or simply an alternative to ACE inhibitors|[quest]|
15:03: posted Osteopontin modulates angiotensin II|[ndash]|induced inflammation, oxidative stress, and fibrosis of the kidney
14:58: posted Hemodialysis access failure: a call to action|[mdash]|revisited
14:57: posted Systematic reviews and meta-analyses: when they are useful and when to be careful
14:57: posted Basophils and mast cells in renal injury
14:53: posted Cell Migration
14:51: posted Cell Imaging Techniques
14:50: posted Cell Cycle Control
14:48: posted Biomedical Informatics (Table of contents)
14:41: posted Apoptosis
14:39: posted Apoptosis Methods and Protocols
14:26: posted Advances in protein turnover analysis at the global level and biological insights.
14:24: posted Affinity Chromatography
14:21: posted 2D PAGE: Sample Preparation and Fractionation (2)
14:21: posted 2D PAGE: Sample Preparation and Fractionation (1)
04:45: posted Renoprotective effects of angiotensin II receptor blocker, candesartan cilexetil, in patients with stage 4-5 chronic kidney disease.
04:31: posted Windows to the ward: graphically oriented report forms. Presentation of complex, interrelated laboratory data for electrophoresis/immunofixation, cerebrospinal fluid, and urinary protein profiles.
04:28: posted Patterns of Proteinuria: Urinary Sodium Dodecyl Sulfate Electrophoresis Versus Immunonephelometric Protein Marker Measurement Followed by Interpretation with the Knowledge-Based System MDI-LabLink
02:46: posted Potential for vitamin D receptor agonists in the treatment of cardiovascular disease.
02:41: posted Diabetes and fractures: an overshadowed association.
02:38: posted CKD and mortality risk in older people: a community-based population study in the United Kingdom.
02:38: posted Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function.
02:36: posted Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials.
02:36: posted International Diabetes Federation: An update of the evidence concerning the prevention of type 2 diabetes.
02:36: posted C-Reactive Protein and Coronary Disease. Is There a Causal Link?
02:35: posted Using nontraditional risk factors in coronary heart disease risk assessment: U.S. Preventive Services Task Force recommendation statement.
02:35: posted Emerging risk factors for coronary heart disease: a summary of systematic reviews conducted for the U.S. Preventive Services Task Force.
02:35: posted C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.
02:33: posted Evidence-based medicine, systematic reviews, and guidelines in interventional pain management: part 6. Systematic reviews and meta-analyses of observational studies.
02:33: posted Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
02:33: posted Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis.
02:33: posted Ezetimibe for the treatment of hypercholesterolaemia: a systematic review and economic evaluation.
02:31: posted Evaluating the causal relevance of diverse risk markers: horizontal systematic review.
02:31: posted "Prevention of cardiovascular disease: why do we neglect the most potent intervention?
02:21: posted Pharmacotherapy for hypertension in the elderly.
02:19: posted Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma.
02:13: posted Clostridium difficile: emerging public health threat and other nosocomial or hospital acquired infections. Introduction.
02:13: posted Healthcare-associated Infections: epidemiology, prevention, and therapy.
02:10: posted Alternative and complementary medicine for preventing and treating cardiovascular disease.
02:09: posted MRSA: an evolving pathogen.
02:09: posted Methicillin-resistant Staphylococcus aureus bacteremia and pneumonia.
02:08: posted Oral antimicrobial options for the treatment of skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in the UK.
02:07: posted Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections.
02:07: posted Health care-associated MRSA versus community-associated MRSA.
02:06: posted Care of the cirrhotic patient.
02:04: posted Substance-related disorders in adults.
02:04: posted Long-term weight loss from lifestyle intervention benefits blood pressure?: a systematic review.
02:03: posted Miliary, central nervous system, and genitourinary tuberculosis.
02:03: posted Correlation Between Blood Pressure Responses to Dietary Sodium and Potassium Intervention in a Chinese Population.
02:02: posted Reduced dietary salt for prevention of cardiovascular disease.

2009-11-17

2009-11-16

16:28: posted Protein Blotting and Detection-Methods in Molecular Biology
16:24: posted Proteomics-Methods in Molecular Biology
09:53: posted Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy.
05:07: posted Evaluation of proteinuria and GFR to diagnose and classify kidney disease: Systematic review and proof of concept
05:06: posted Risk of hyperkalemia in nondiabetic patients with chronic kidney disease receiving antihypertensive therapy.
05:04: posted Regulation of blood pressure and cardiovascular function by renalase.
05:04: posted Influence of T-calcium channel blocker treatment on deterioration of renal function in chronic kidney disease.
04:58: posted Long-term decline in renal function is linked to initial pulse pressure in the essential hypertensive.
04:56: posted Proteinuria as a predictor of renal functional outcome after revascularization in atherosclerotic renovascular disease (ARVD).
04:55: posted Perioperative cardiovascular assessment of patients undergoing noncardiac surgery.
04:53: posted Does perioperative hemodynamic optimization protect renal function in surgical patients? A meta-analytic study.
04:50: posted Conservative treatment of the uremic syndrome.
04:47: posted Molecular and clinical investigations in patients with low-renin hypertension.
02:49: posted Salt-sensitive blood pressure--an intermediate phenotype predisposing to diabetic nephropathy?
02:49: posted Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity.
02:48: posted Are angiotensin-converting enzyme inhibitors and Angiotensin receptor blockers especially useful for cardiovascular protection?
02:47: posted Achieving blood pressure goals: should angiotensin II receptor blockers become first-line treatment in hypertension?
02:46: posted A MAPK scaffold lends a helping hand.
02:46: posted A scaffold makes the switch.
02:45: posted The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways.
02:45: posted When kinases meet mathematics: the systems biology of MAPK signalling.
02:43: posted Regulation of MAP kinase signaling modules by scaffold proteins in mammals.
02:43: posted Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions.
02:40: posted Effects of angiotensin II receptor blockers on diabetic nephropathy.
02:39: posted Scale-free networks: a decade and beyond.
02:35: posted Global Health Assistance for Chronic Illness: A Look at the Practical
02:23: posted Recent advances in cardiovascular risk reduction: implications of ONTARGET.
02:18: posted Complementary effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in slowing the progression of chronic kidney disease
02:18: posted Protective effects of doxycycline in ischemia/reperfusion injury on kidney.
02:18: posted 25-Hydroxyvitamin D Levels, Race, and the Progression of Kidney Disease
02:17: posted LPLS-regression: a method for prediction and classification under the influence of background information on predictor variables
02:15: posted Antihypertensive drugs, dietary salt, and renal protection: how low should you go and with which therapy?
02:12: posted Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care.
02:10: posted A comprehensive review on salt and health and current experience of worldwide salt reduction programmes.
02:09: posted Salt intakes around the world: implications for public health.
02:09: posted Salt intake, blood pressure and clinical outcomes.
02:06: posted Salt and high blood pressure.
02:06: posted Asian-African summit explores how to tackle rise in non-communicable diseases.
02:05: posted Preventing chronic illness.
02:02: posted Measuring the global burden of disease and epidemiological transitions: 2002-2030.
01:58: posted Chronic non-communicable diseases.
01:57: posted Population causes and consequences of leading chronic diseases: a comparative analysis of prevailing explanations.
01:56: posted The double burden of communicable and non-communicable diseases in developing countries.
01:48: posted Rethinking global health challenges: towards a 'global compact' for reducing the burden of chronic disease.

2009-11-15

2009-11-14

2009-11-13

10:44: posted TGF{beta} family signaling: novel insights in development and disease
10:42: posted The extracellular regulation of bone morphogenetic protein signaling
10:42: posted Informatics approaches to understanding TGF{beta} pathway regulation
10:41: posted SnapShot: Convenient, Comprehensive, and Now Clickable
10:40: posted The regulation of TGFbeta signal transduction.
10:39: posted Modulation of the transforming growth factor-beta1-induced Smad phosphorylation by the extracellular matrix receptor beta1-integrin.
10:38: posted Hydrogen peroxide as a cell-survival signaling molecule.
10:37: posted Mechanisms of MAPK pathway mediating TGF-beta(1)/Smad signal in keloid fibroblasts.
10:37: posted PI-3 kinase pathway can mediate the effect of TGF-beta1 in inducing the expression of SHARP-2 in LLC-PK1 cells.
10:36: posted Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1.
10:35: posted Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3.
10:34: posted In silico investigation of ADAM12 effect on TGF-beta receptors trafficking.
10:28: posted A mathematical model of the stoichiometric control of Smad complex formation in TGF-beta signal transduction pathway.
04:41: posted TGFbeta versatility: PI3K as a critical mediator of distinct cell type and context specific responses.
04:38: posted Phospholipase D in platelets and other cells.
04:37: posted Cross talk between phospholipase D and MAP kinases activities.
04:35: posted Biophysics and function of phosphatidic acid: A molecular perspective
04:35: posted Modulation of phospholipase D activity in vitro.
04:33: posted Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
04:33: posted Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid.
04:32: posted Developmental regulation of p70 S6 kinase by a G protein-coupled receptor dynamically modelized in primary cells.
04:30: posted Phosphatidate degradation: Phosphatidate phosphatases (lipins) and lipid phosphate phosphatases
04:30: posted Enzymatic measurement of phosphatidic acid in cultured cells.
04:29: posted The ubiquitination of ribosomal S6 kinases is independent from the mitogen-induced phosphorylation/activation of the kinase.
04:28: posted Over-expression of phospholipase D isozymes down-regulates protein kinase CKII activity via proteasome-dependent CKIIbeta degradation in NIH3T3 cells.
04:27: posted Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
04:27: posted Nutrient control of TORC1, a cell-cycle regulator
04:26: posted Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.
04:22: posted Regulation and localization of ribosomal protein S6 kinase 1 isoforms.
04:19: posted Tubers and tumors: rapamycin therapy for benign and malignant tumors.
04:19: posted Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma.
04:17: posted mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
04:11: posted Thromboprophylaxis in patients with lower limb immobilisation - review of current status.
04:09: posted Venous thromboembolism - management in general practice.
02:42: posted [Phospholipase D in mammalian cells: structure, properties, physiological and pathological role]
02:31: posted Live cell imaging of phosphoinositides with expressed inositide binding protein domains
02:29: posted First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functions
02:28: posted Mammalian phosphoinositide kinases and phosphatases
02:27: posted G protein-coupled receptor cross-talk: pivotal roles of protein phosphorylation and protein?protein interactions
02:20: posted GPCR signalling to the translation machinery
02:14: posted Optimal targeting of the mTORC1 kinase in human cancer.
02:13: posted Targeting the EGFR and the PKB pathway in cancer.
02:13: posted Current status and challenges associated with targeting mTOR for cancer therapy.
02:05: posted The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions.
02:05: posted Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy.
02:02: posted Target profiling of small molecules by chemical proteomics.
02:01: posted Design, synthesis and selection of DNA-encoded small-molecule libraries.
02:00: posted Factors underlying sensitivity of cancers to small-molecule kinase inhibitors.
02:00: posted Discovery and development of aurora kinase inhibitors as anticancer agents.
01:57: posted Molecular targeted therapies for solid tumors: management of side effects.
01:54: posted Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.
01:50: posted Raptor, a binding partner of target of rapamycin.
01:50: posted Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.
01:47: posted Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR.
01:45: posted Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors).
01:45: posted Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton.
01:43: posted Phospholipase D.
01:40: posted Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides.
01:40: posted Cell physiology of cAMP sensor Epac.
01:36: posted Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.
01:35: posted Dynamic phospholipid signaling by G protein-coupled receptors.
01:35: posted Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.
01:34: posted Phospholipase D in endocytosis and endosomal recycling pathways.

2009-11-12

10:10: posted The angiotensin II type 2 receptor and the kidney.
10:09: posted Intrarenal Mouse Renin-angiotensin System during Ang II-induced Hypertension and ACE inhibition.
10:08: posted The evolving story of the RAAS in hypertension, diabetes and CV disease - moving from macrovascular to microvascular targets.
10:07: posted Acid-base regulation of angiotensin receptors in the kidney.
10:00: posted Seven decades of angiotensin (1939-2009).
09:59: posted Sequential activation of the reactive oxygen species/angiotensinogen/renin-angiotensin system axis in renal injury of type 2 diabetic rats.
09:59: posted Intrarenal expression of microRNAs in patients with IgA nephropathy.
09:51: posted Application of A Serum Protein Fingerprinting Model in The Diagnosis of Type 2 Diabetic Nephropathy
09:40: posted Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor.
09:39: posted Roles of muscarinic acetylcholine receptors in interleukin-2 synthesis in lymphocytes.
09:39: posted mTORbeta splicing isoform promotes cell proliferation and tumorigenesis.
09:38: posted Depletion of mammalian target of rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of beta-catenin and elicits distinct features of cardiomyocyte hypertrophy.
09:38: posted Mammalian Target of Rapamycin. MasTOR Mediator of Cellular Changes in Pathological States?
09:36: posted mTOR signaling at a glance.
09:30: posted Experimental and computational tools useful for (re)construction of dynamic kinase-substrate networks.
09:29: posted Quantification of Membrane Proteins Using Nonspecific Protease Digestions.
09:22: posted Sensitive multiplexed analysis of kinase activities and activity-based kinase identification.
09:18: posted Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.
09:00: posted Growth suppressive cytokines and the AKT/mTOR pathway.
08:58: posted Regulation Mechanisms and Signaling Pathways of Autophagy.
08:58: posted Monitoring protein kinases in cellular media with highly selective chimeric reporters.
08:54: posted Expression of phospholipase D isoforms in mammalian cells
08:53: posted Regulation of Tissue Growth through Nutrient Sensing
08:53: posted Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts