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psique's profile

About me

Username:	psique
Name:	laura l. kilarski
Job title:	PhD student
Affiliation:	Cardiff University, Wales
Web page:	http://psiqueii.blogspot.com
Joined:	2007-10-23

What I do

Not specified

Interests

neuroscience: synaptic plasticity, addiction, depression, eating disorders, adult neurogenesis, personality disorders, neurodegeneration, brain machine interfaces

pharmacology: pharmocogenomics, pharmacogenetics, drug discovery/development, antidepressants, nootropics, drugs of abuse

biochemistry: cell signalling, protein structure & function relationships, intracellular pathways, computational biochemistry

genetics: (single nucleotide) polymorphisms, hereditary susceptibility to disease, molecular evolution, RNAi, gene therapy

Recent Activity

2008-10-10

16:09: posted The development and impact of 454 sequencing
16:06: posted What would you do if you could sequence everything?
10:49: posted Gerontology: Healthy old age

2008-10-09

15:12: posted Genome-wide association studies for complex traits: consensus, uncertainty and challenges

2008-10-06

2008-10-03

16:45: posted Reactivation in Ventral Striatum during Hippocampal Ripples: Evidence for the Binding of Reward and Spatial Memories?

2008-10-02

13:51: posted Integrated detection and population-genetic analysis of SNPs and copy number variation.
13:50: posted Systematic assessment of copy number variant detection via genome-wide SNP genotyping.
13:03: posted Neuroscience: Fragile dopamine
12:54: posted Regenerative medicine: Short cut to cell replacement
11:58: posted Metabolomics: Biochemistry's new look

2008-09-25

10:59: posted A wiki for the life sciences where authorship matters
10:58: posted WikiPathways: Pathway Editing for the People

2008-09-24

15:29: posted Genetic variation in human gene expression.
14:23: posted A haplotype map of the human genome.
13:40: posted Genome-wide associations of gene expression variation in humans.

2008-09-23

16:24: posted Identification of loci associated with schizophrenia by genome-wide association and follow-up
16:23: posted A Systematic Genomewide Linkage Study in 353 Sib Pairs with Schizophrenia
16:21: posted On multiple-testing correction in genome-wide association studies.
16:18: posted A survey of genetic human cortical gene expression.
16:17: posted Relative Impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes
16:14: posted Estimation of significance thresholds for genomewide association scans.
16:06: posted Is there a code embedded in proteins that is based on post-translational modifications?
15:47: posted Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
14:44: posted Genomics and genome-wide association studies: An integrative approach to expression QTL mapping
07:54: posted Cell Biology Select (Protein misfolding)

2008-09-22

18:03: posted A tutorial on statistical methods for population association studies
18:02: posted From the editors
17:59: posted Genetic relatedness analysis: modern data and new challenges
17:58: posted Computer programs for population genetics data analysis: a survival guide
17:57: posted Modern computational approaches for analysing molecular genetic variation data
16:10: posted Linkage disequilibrium — understanding the evolutionary past and mapping the medical future
16:08: posted Heritability in the genomics era — concepts and misconceptions
13:21: posted Linkage Disequilibrium: Ancient History Drives the New Genetics
12:53: posted Haplotype blocks and linkage disequilibrium in the human genome.
12:50: posted Increased level of linkage disequilibrium in rural compared with urban communities: a factor to consider in association-study design.

2008-09-21

20:50: posted Cholinergic mediation of attention: contributions of phasic and tonic increases in prefrontal cholinergic activity.
20:49: posted <i>Molecular Genetics of Attention</i>
20:47: posted Toward a neurogenetic theory of neuroticism.

2008-09-19

11:29: posted Runs of Homozygosity in European Populations
11:24: posted QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.
11:21: posted PLINK: a tool set for whole-genome association and population-based linkage analyses.

2008-09-18

16:15: posted Schizo
13:29: posted A heterozygous effect for PINK1 mutations in Parkinson's disease?
13:28: posted Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.
13:26: posted PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism
13:25: posted Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations
13:23: posted Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
13:23: posted Distribution of PINK1 and LRRK2 in rat and mouse brain
13:22: posted Parkinson's disease: Pro-survival effects of PINK1
13:21: posted PINK1 protein in normal human brain and Parkinson's disease
13:19: posted Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
13:18: posted Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation
13:16: posted Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
13:15: posted The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
13:13: posted Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2
12:59: posted Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
12:58: posted Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
12:57: posted The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
12:56: posted HtrA2 and Parkinson's disease: think PINK?
09:14: posted Reduced efficacy of fluoxetine following MDMA ("Ecstasy")-induced serotonin loss in rats

2008-09-17

15:03: posted LRRK2 mutations in Basque patients with Parkinson's disease - Authors' reply
14:59: posted LRRK2 mutations in Basque patients with Parkinson's disease
14:44: posted Non-dopaminergic treatments in development for Parkinson's disease
13:57: posted Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia.
13:51: posted A unifying hypothesis for explaining the mechanism of amyloid formation under conditions of increased oxidative stress
13:51: posted Parkinson disease: primacy of age as a risk factor for mitochondrial dysfunction

2008-09-16

21:55: posted Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
21:52: posted Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.
21:52: posted Homozygous PINK1 C-terminus mutation causing early-onset parkinsonism.
21:51: posted Novel PINK1 mutations in early-onset parkinsonism.
21:50: posted PINK1 mutations are associated with sporadic early-onset parkinsonism.
21:47: posted PINK1 (PARK6) associated Parkinson disease in Ireland.
21:44: posted Biological effects of the PINK1 c.1366CT mutation: implications in Parkinson disease pathogenesis
21:41: posted Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa
21:38: posted Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit?

2008-09-15

17:02: posted The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism
16:57: posted Characterization of PINK1 processing, stability, and subcellular localization
16:53: posted Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.
13:50: posted Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data
11:36: posted alpha-Synuclein locus triplication causes Parkinson's disease.
10:50: posted Global variation in copy number in the human genome

2008-09-14