CiteULike: Author Blas

The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus)

Ray Ming — 2008-04-23T19:37:29-00:00

Nature, Vol. 452, No. 7190. (24 April 2008), pp. 991-996.

Identification and analysis of a glutaryl-CoA dehydrogenase-encoding gene and its cognate transcriptional regulator from Azoarcus sp. CIB

Blazquez — 2008-01-13T00:12:30-00:00

Environmental Microbiology, Vol. 10, No. 2. (February 2008), pp. 474-482.

In this work, the gcdH gene from the denitrifying beta-proteobacterium Azoarcus sp. CIB was shown to encode a glutaryl-CoA dehydrogenase, which is essential for the anaerobic catabolism of many aromatic compounds and some alicyclic and dicarboxylic acids. The primary structure of the GcdH protein is highly conserved in many organisms. The divergently transcribed gcdR gene, encoding a LysR-type transcriptional regulator, accounts for the glutaconate/glutarate-specific activation of the Pg promoter driving expression of gcdH. The Azoarcus sp. CIBdgcdH mutant strain harbouring a disrupted gcdH gene was used as host to identify heterologous gcdH genes, such as that from Pseudomonas putida KT2440. Moreover, the expression of gcdH from P. putida can be efficiently controlled by the GcdR activator in Azoarcus sp. CIB, demonstrating the existence of cross-talk between GcdR regulators and gcdH promoters from members of different phylogenetic subgroups of proteobacteria.

Chromosomal location and gene paucity of the male specific region on papaya Y chromosome

Yu — 2007-08-28T19:05:45-00:00

Molecular Genetics and Genomics, Vol. 278, No. 2. (August 2007), pp. 177-185.

Strategic emphases for tropical diseases research: a TDR perspective.

JH Remme — 2008-04-13T14:29:48-00:00

Trends in microbiology, Vol. 10, No. 10. (October 2002), pp. 435-440.

Setting priorities for health research is a difficult task, especially for the neglected diseases of the poor. A new approach to priority setting for tropical diseases research has been adopted by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (known as the TDR). Priorities are defined on the basis of a comprehensive analysis of research needs and research opportunities for each of the ten major tropical diseases in the TDR portfolio. The resulting strategic emphases matrix reflects the priorities for tropical diseases research from the perspective of the TDR. Its purpose is not to impose global research priorities, but we believe the results could be useful to other organizations.

Phase equilibria, excess properties, and Henry's constants of the water + carbon dioxide binary mixture

Dos — 2008-01-03T12:10:56-00:00

J. Phys. Chem. C, Vol. 111, No. 43. (2007), pp. 15924-15934.

The high-pressure phase diagram and other thermodynamic properties of the water + carbon dioxide binary mixture are examined using the SAFT-VR approach. The carbon dioxide molecule is modeled as two spherical segments tangentially bonded. The water molecule is modeled as a spherical segment with four associating sites to represent the hydrogen bonding. Dispersive interactions are modeled using the square-well intermolecular potential. The polar and quadrupolar interactions present in water and carbon dioxide are treated in an effective way via square-well potentials of variable range. The optimized intermolecular parameters are taken from the works of Galindo and Bias (Fluid Phase Equilib. 2002, 194-197, 502; J. Phys. Chem. B 2002, 106, 4503) and Clark et al. (Mol. Phys. 2006, 22-24, 3561) for carbon dioxide and water, respectively. The phase diagram of the mixture exhibits a number of interesting features: type-III phase behavior according to the classification of Scott and Konynenburg, three-phase behavior at low temperatures with its corresponding upper critical end point, a gas-liquid critical line at high temperatures and pressures that continuously changes from gas-liquid to liquid-liquid as the pressure is increased and gas-gas immiscibility of second kind. Only one unlike interaction parameter is fitted to give the best possible representation of the temperature minimum of the gas-liquid critical line of the mixture. This unlike parameter is then used in a transferable manner to study the complete pressure-temperature-composition phase diagram. The phase diagram calculated with SAFT-VR is in excellent agreement with the experimental data taken from the literature in a wide range of thermodynamic conditions. The theory is also able to predict a good qualitative description of the excess molar volume and enthalpy of the mixture as well as the most important features of the Henry's constants at different temperatures. © 2007 American Chemical Society.

Exploring the Essential Dynamics of B-DNA

A Perez — 2007-12-13T16:27:35-00:00

Journal of Chemical Theory and Computation, Vol. 1, No. 5. (13 September 2005), pp. 790-800.

Abstract: The essential dynamics of different normal and chemically modified DNA duplexes pertaining to the B family have been extensively explored from molecular dynamics simulations using powerful data mining techniques. Some of them, which are presented here for the first time, might become standard, powerful tools to characterize the dynamical behavior of complex biomolecular structures such as nucleic acids. Their potential impact is illustrated by examining the extended trajectories sampled for the set of DNA duplexes considered in this study, which allows us to discuss the degree of conservation of the natural flexibility pattern of the different DNAs, which in specific cases contain severe chemical modifications.

Transverse Fierz-Pauli symmetry

E Alvarez — 2006-06-05T16:29:58-00:00

(2 Jun 2006)

We consider some flat space theories for spin 2 gravitons, with less invariance than full diffeomorphisms. For the massless case, classical stability and absence of ghosts require invariance under transverse diffeomorphisms (TDiff). Generic TDiff invariant theories contain a propagating scalar, which disappears if the symmetry is enhanced in one of two ways. One possibility is to consider full diffeomorphisms (Diff). The other (which we denote WTDiff) adds a Weyl symmetry, by which the Lagrangian becomes independent of the trace. The first possibility corresponds to General Relativity, whereas the second corresponds to "unimodular" gravity (in a certain gauge). Phenomenologically, both options are equally acceptable. For massive gravitons, the situation is more restrictive. Up to field redefinitions, classical stability and absence of ghosts lead directly to the standard Fierz-Pauli Lagrangian. In this sense, the WTDiff theory is more rigid against deformations than linearized GR, since a mass term cannot be added without provoking the appearance of ghosts.

Strategic emphases for tropical diseases research: a TDR perspective.

JH Remme — 2005-09-02T23:52:19-00:00

Trends Parasitol, Vol. 18, No. 10. (October 2002), pp. 421-426.

Setting priorities for health research is a difficult task, especially for the neglected diseases of the poor. A new approach to priority setting for tropical diseases research has been adopted by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (known as the TDR). Priorities are defined on the basis of a comprehensive analysis of research needs and research opportunities for each of the ten major tropical diseases in the TDR portfolio. The resulting strategic emphases matrix reflects the priorities for tropical diseases research from the perspective of the TDR. Its purpose is not to impose global research priorities, but we believe the results could be useful to other organizations.