Thu, 24 Jul 2008 23:15:41 BST CiteULike: AlfonsoVicenteSuarez's il-10-gut http://www.citeulike.org/user/AlfonsoVicenteSuarez/tag/il-10-gut CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2844579 <i>Nature, Vol. 453, No. 7195., pp. 620-625.</i> A microbial symbiosis factor prevents intestinal inflammatory disease Sarkis Mazmanian June Round Dennis Kasper doi:10.1038/nature07008 Nature, Vol. 453, No. 7195., pp. 620-625. 2008-05-29T14:31:13-00:00 Nature 0028-0836 453 7195 620 625 Nature Publishing Group il-10-gut mucosal-immunology http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1507575 <i>Am J Pathol, Vol. 153, No. 1. (1 July 1998), pp. 121-130.</i><br /><br />A dysregulated secretion of contra-inflammatory cytokines such as interleukin-10 (IL-10) could play a role in the pathogenesis of inflammatory bowel disease (IBD). We have investigated the expression of IL-10 in gut tissues from patients with Crohn's disease (CD), ulcerative colitis (UC) and controls by mRNA in situ hybridization and immunohistochemistry. Intestinal epithelial cells were found to express IL-10 mRNA and IL-10 protein in all of the tissues investigated without any major differences in the expression patterns. However, compared with noninflamed gut, significantly increased numbers of mononuclear cells (MNCs) producing IL-10 were present in inflamed gut, both in CD and UC. This cytokine was expressed most prominently by inflammatory infiltrates enriched in macrophages, although T cells seem to contribute to its production as well. Elevated IL-10 expression in IBD was mainly detected in the submucosa, whereas IL-10 production by lamina propria cells remained comparably low. In contrast, the expression of IL-1beta mRNA was preferentially increased in the lamina propria. Our data argue against a general deficiency in IL-10 production in IBD. The results suggest rather that the local production of IL-10 by mucosal MNCs in IBD is insufficient to down-regulate pro-inflammatory cytokines such as IL-1beta in the lamina propria compartment. In Situ Expression of Interleukin-10 in Noninflamed Human Gut and in Inflammatory Bowel Disease Frank Autschbach Jutta Braunstein Burkhard Helmke Ivan Zuna Guido Schurmann Zofia Niemir Reinhard Wallich Herwart Otto Stefan Meuer Am J Pathol, Vol. 153, No. 1. (1 July 1998), pp. 121-130. 2007-07-27T18:56:09-00:00 1998 Am J Pathol 153 1 121 130 il-10-gut