Thu, 07 Aug 2008 21:37:59 BST CiteULike: AlfonsoVicenteSuarez's immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/tag/immunology-basic CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2953671 <i>Immunity, Vol. 28, No. 6. (13 June 2008), pp. 787-798.</i><br /><br />Summary The nature of crosspriming immunogens for CD8+ T cell responses is highly controversial. By using a panel of T cell receptor-like antibodies specific for viral peptides bound to mouse Db major histocompatibility complex class I molecules, we show that an exceptional peptide (PA224-233) expressed as a viral minigene product formed a sizeable cytosolic pool continuously presented for hours after protein synthesis was inhibited. PA224-233 pool formation required active cytosolic heat-shock protein 90 but not ER g96 and uniquely enabled crosspriming by this peptide. These findings demonstrate that exceptional class I binding oligopeptides that escape proteolytic degradation are potent crosspriming agents. Thus, the feeble immunogenicity of natural proteasome products in crosspriming can be attributed to their evanescence in donor cells and not an absolute inability of cytosolic oligopeptides to be transferred to and presented by professional antigen-presenting cells. The Exception that Reinforces the Rule: Crosspriming by Cytosolic Peptides that Escape Degradation Avital Lev Kazuyo Takeda Damien Zanker Jason Maynard Peniel Dimberu Elizabeth Waffarn James Gibbs Nir Netzer Michael Princiotta Len Neckers Didier Picard Christopher Nicchitta Weisan Chen Yoram Reiter Jack Bennink Jonathan Yewdell doi:10.1016/j.immuni.2008.04.015 Immunity, Vol. 28, No. 6. (13 June 2008), pp. 787-798. 2008-07-02T21:07:48-00:00 2008 Immunity 28 6 787 798 immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1438186 <i></i> INNATE IMMUNE RECOGNITION - Annual Review of Immunology, 20(1):197 - Abstract 2007-07-05T17:54:46-00:00 immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1437968 <i>Trends in Immunology, Vol. 25, No. 2. (February 2004), pp. 105-111.</i><br /><br />When and how adaptive immunity emerged is one of the fundamental questions in immunology. Accumulated evidence suggests that the key components of adaptive immunity, rearranging receptor genes and the MHC, are unique to jawed vertebrates. Recent studies in protochordates, in particular, the draft genome sequence of the ascidian Ciona intestinalis, are providing important clues for understanding the origin of antigen receptors and the MHC. We discuss a group of newly identified protochordate genes along with some cold-blooded vertebrate genes, the ancestors of which might have provided key elements of antigen receptors. The organization of the proto-MHCs in protochordates provides convincing evidence that the MHC regions of jawed vertebrates emerged as a result of two rounds of chromosomal duplication. On the origins of the adaptive immune system: novel insights from invertebrates and cold-blooded vertebrates Masanori Kasahara Takashi Suzuki Louis Pasquier Trends in Immunology, Vol. 25, No. 2. (February 2004), pp. 105-111. 2007-07-05T15:49:06-00:00 2004 Trends in Immunology 25 2 105 111 immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1373050 <i></i> THE EVOLUTION OF ADAPTIVE IMMUNITY - Annual Review of Immunology, 24(1):497 - Abstract 2007-06-08T15:33:02-00:00 immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/808558 <i>Cell, Vol. 124, No. 4. (24 February 2006), pp. 815-822.</i><br /><br />A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led to the evolution of alternative ways for lymphocytes to generate diverse antigen receptors for use in recognizing and repelling pathogen invaders. All jawed vertebrates assemble their antigen-receptor genes through recombinatorial rearrangement of different immunoglobulin or T cell receptor gene segments. The surviving jawless vertebrates, lampreys and hagfish, instead solved the receptor diversification problem by the recombinatorial assembly of leucine-rich-repeat genetic modules to encode variable lymphocyte receptors. The convergent evolution of these remarkably different adaptive immune systems involved innovative genetic modification of innate-immune-system components. The Evolution of Adaptive Immune Systems Max Cooper Matthew Alder doi:10.1016/j.cell.2006.02.001 Cell, Vol. 124, No. 4. (24 February 2006), pp. 815-822. 2006-08-19T23:56:23-00:00 2006 Cell 124 4 815 822 immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1373028 <i>Immunity, Vol. 21, No. 5. (November 2004), pp. 607-615.</i> The Acquired Immune System: A Vantage from Beneath Stephen Hedrick Immunity, Vol. 21, No. 5. (November 2004), pp. 607-615. 2007-06-08T15:17:26-00:00 2004 Immunity 21 5 607 615 immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1321827 <i>N Engl J Med, Vol. 343, No. 2. (13 July 2000), pp. 108-117.</i> The immune system. Second of two parts. PJ Delves IM Roitt N Engl J Med, Vol. 343, No. 2. (13 July 2000), pp. 108-117. 2007-05-23T15:51:34-00:00 2000 N Engl J Med 0028-4793 343 2 108 117 immunology-basic http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1321822 <i>N Engl J Med, Vol. 343, No. 1. (6 July 2000), pp. 37-49.</i> The immune system. First of two parts. PJ Delves IM Roitt N Engl J Med, Vol. 343, No. 1. (6 July 2000), pp. 37-49. 2007-05-23T15:48:50-00:00 2000 N Engl J Med 0028-4793 343 1 37 49 immunology-basic