Fri, 04 Jul 2008 23:51:09 BST CiteULike: AlfonsoVicenteSuarez's mucosal-immunology http://www.citeulike.org/user/AlfonsoVicenteSuarez/tag/mucosal-immunology CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2953553 <i>Immunity, Vol. 28, No. 6. (13 June 2008), pp. 740-750.</i><br /><br />The gut mucosa is exposed to a large community of commensal bacteria that are required for the processing of nutrients and the education of the local immune system. Conversely, the gut immune system generates innate and adaptive responses that shape the composition of the local microbiota. One striking feature of intestinal adaptive immunity is its ability to generate massive amounts of noninflammatory immunoglobulin A (IgA) antibodies through multiple follicular and extrafollicular pathways that operate in the presence or absence of cognate T-B cell interactions. Here we discuss the role of intestinal IgA in host-commensal mutualism, immune protection, and tolerance and summarize recent advances on the role of innate immune cells in intestinal IgA production. The Biology of Intestinal Immunoglobulin A Responses Andrea Cerutti Maria Rescigno doi:10.1016/j.immuni.2008.05.001 Immunity, Vol. 28, No. 6. (13 June 2008), pp. 740-750. 2008-07-02T20:51:00-00:00 2008 Immunity 28 6 740 750 mucosal-immunology http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2838041 <i>J Immunol, Vol. 178, No. 7. (1 April 2007), pp. 4548-4556.</i><br /><br />The role of TLRs on intestinal epithelial cells (IECs) is controversial, and the mechanisms by which TLRs influence mucosal homeostasis are obscure. In this study, we report that genomic dsRNA from rotavirus, and its synthetic analog polyinosinic-polycytidylic acid (poly(I:C)), induce severe mucosal injury in the small intestine. Upon engaging TLR3 on IECs, dsRNA triggers IECs to secrete IL-15, which functions to increase the percentage of CD3+NK1.1+ intestinal intraepithelial lymphocytes (IELs) and enhances the cytotoxicity of IELs. Moreover, The CD3+NK1.1+ IELs are proved as CD8alphaalpha+ IELs. These results provide direct evidence that abnormal TLR3 signaling contributes to breaking down mucosal homeostasis and the first evidence of pathogenic effects mediated by CD8alphaalpha+ IELs. The data also suggest that genomic dsRNA may be involved in the pathogenesis of acute rotavirus gastroenteritis. Recognition of Double-Stranded RNA by TLR3 Induces Severe Small Intestinal Injury in Mice Rongbin Zhou Haiming Wei Rui Sun Zhigang Tian J Immunol, Vol. 178, No. 7. (1 April 2007), pp. 4548-4556. 2008-05-27T18:31:42-00:00 2007 J Immunol 178 7 4548 4556 mucosal-immunology ra rae-1 http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/2319701 <i></i> Starting at the Beginning: New Perspectives on the Biology of Mucosal T Cells - Annual Review of Immunology, 22(1):217 - Abstract Hilde Cheroutre 2008-02-01T15:03:47-00:00 mucosal-immunology