Fri, 04 Jul 2008 23:44:22 BST CiteULike: AlfonsoVicenteSuarez's tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/tag/tlr-signaling CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1781484 <i></i> The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling : Article : Nature Reviews Immunology 2007-10-17T21:33:35-00:00 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1781374 <i></i> Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments 2007-10-17T20:39:38-00:00 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/472747 <i>Cell Death and Differentiation, Vol. aop, No. current.</i> TLR signaling T Kawai S Akira doi:10.1038/sj.cdd.4401850 Cell Death and Differentiation, Vol. aop, No. current. 2006-01-20T16:53:40-00:00 Cell Death and Differentiation 1350-9047 aop current Nature Publishing Group tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1558552 <i></i> Recognition and Signaling by Toll-Like Receptors - Annual Review of Cell and Developmental Biology, 22(1):409 - Full Text 2007-08-13T18:46:46-00:00 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1429299 <i>Science, Vol. 300, No. 5625. (6 June 2003), pp. 1524-1525.</i><br /><br />Members of the Toll-like receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharide and viral double-stranded RNA, and activate signaling pathways that result in immune responses against microbial infections. All TLRs activate MyD88-dependent pathways to induce a core set of stereotyped responses, such as inflammation. However, individual TLRs can also induce immune responses that are tailored to a given microbial infection. Thus, these receptors are involved in both innate and adaptive immune responses. The mechanisms and components of these varied responses are only partly understood. Given the importance of TLRs in host defense, dissection of the pathways they activate has become an important emerging research focus. TLRs and their pathways are numerous; Science's Signal Transduction Knowledge Environment's TLR Connections Map provides an immediate, clear overview of the known components and relations of this complex system. 10.1126/science.1085536 Toll-Like Receptor Signaling Pathways Gregory Barton Ruslan Medzhitov doi:10.1126/science.1085536 Science, Vol. 300, No. 5625. (6 June 2003), pp. 1524-1525. 2007-07-02T18:50:58-00:00 2003 Science 300 5625 1524 1525 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1374602 <i></i> Recognition and Signaling by Toll-Like Receptors - Annual Review of Cell and Developmental Biology, 22(1):409 - Abstract 2007-06-09T17:52:22-00:00 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1374598 <i>Arthritis Res Ther, Vol. 7, No. 1. (2005), pp. 12-19.</i><br /><br />The family of Toll-like receptors (TLRs) senses conserved structures found in a broad range of pathogens, causing innate immune responses that include the production of inflammatory cytokines, chemokines and interferons. The signal transduction is initiated from the Toll/interleukin-1 receptor (TIR) domain of TLRs after pathogen recognition. Almost all TLRs use a TIR-containing adapter MyD88 to activate a common signaling pathway that results in the activation of NF-kappaB to express cytokine genes relevant to inflammation. Recently, three further TIR-containing adapters have been identified and shown to selectively interact with several TLRs. In particular, activation of the TRIF-dependent pathway confers antiviral responses by inducing anti-viral genes including that encoding interferon-beta. Taken together, these results indicate that the interaction between individual TLRs and the different combinations of adapters directs appropriate responses against distinct pathogens. Toll-like receptor downstream signaling. T Kawai S Akira doi:10.1186/ar1469 Arthritis Res Ther, Vol. 7, No. 1. (2005), pp. 12-19. 2007-06-09T17:33:57-00:00 2005 Arthritis Res Ther 1478-6362 7 1 12 19 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1374596 <i>Immunology, Vol. 113, No. 2. (October 2004), pp. 153-162.</i><br /><br />An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS - Toll-like receptor 4 (TLR4) - but also in a better appreciation of the complexity of the signalling pathways activated by LPS. Soon after the discovery of TLR4, the formation of a receptor complex in response to LPS, consisting of dimerized TLR4 and MD-2, was described. Intracellular events following the formation of this receptor complex depend on different sets of adapters. An early response, which is dependent on MyD88 and MyD88-like adapter (Mal), leads to the activation of nuclear factor-kappaB (NF-kappaB). A later response to LPS makes use of TIR-domain-containing adapter-inducing interferon-beta (TRIF) and TRIF-related adapter molecule (TRAM), and leads to the late activation of NF-kappaB and IRF3, and to the induction of cytokines, chemokines, and other transcription factors. As LPS signal transduction is an area of intense research and rapid progress, this review is intended to sum up our present understanding of the events following LPS binding to TLR4, and we also attempt to create a model of the signalling pathways activated by LPS. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. EM Pålsson-McDermott LA O'Neill doi:10.1111/j.1365-2567.2004.01976.x Immunology, Vol. 113, No. 2. (October 2004), pp. 153-162. 2007-06-09T17:29:17-00:00 2004 Immunology 0019-2805 113 2 153 162 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1372894 <i>Cell, Vol. 125, No. 5. (2 June 2006), pp. 943-955.</i><br /><br />Toll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial infection. Signaling downstream from TLRs is initiated by the recruitment of adaptor proteins, including MyD88 and TIRAP. These adaptors play essential roles in TLR signaling, but the mechanism of their function is currently unknown. Here we demonstrate that TIRAP and MyD88 have distinct functions and describe a mechanism of recruitment of TIRAP and MyD88 to TLR4. We find that TIRAP contains a phosphatidylinositol 4,5-bisphosphate (PIP2) binding domain, which mediates TIRAP recruitment to the plasma membrane. TIRAP then functions to facilitate MyD88 delivery to activated TLR4 to initiate signal transduction. These results establish that phosphoinositide-mediated adaptor recruitment initiates a specific signal-transduction pathway. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. JC Kagan R Medzhitov doi:10.1016/j.cell.2006.03.047 Cell, Vol. 125, No. 5. (2 June 2006), pp. 943-955. 2007-06-08T14:15:36-00:00 2006 Cell 0092-8674 125 5 943 955 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1353585 <i>Nature (30 May 2007)</i> Gene-specific control of inflammation by TLR-induced chromatin modifications Simmie Foster Diana Hargreaves Ruslan Medzhitov doi:10.1038/nature05836 Nature (30 May 2007) 2007-06-01T00:55:38-00:00 2007 Nature 0028-0836 Nature Publishing Group tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1371342 <i>Nat Rev Immunol, Vol. 4, No. 7. (July 2004), pp. 499-511.</i> TOLL-LIKE RECEPTOR SIGNALLING Shizuo Akira Kiyoshi Takeda doi:10.1038/nri1391 Nat Rev Immunol, Vol. 4, No. 7. (July 2004), pp. 499-511. 2007-06-07T21:20:56-00:00 2004 Nat Rev Immunol 4 7 499 511 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/477346 <i>Nature, Vol. 430, No. 6996. (8 July 2004), pp. 257-263.</i><br /><br />The Toll-like receptors (TLRs) are the key proteins that allow mammals--whether immunologically naive or experienced--to detect microbes. They lie at the core of our inherited resistance to disease, initiating most of the phenomena that occur in the course of infection. Quasi-infectious stimuli that have been used for decades to study inflammatory mechanisms can activate the TLR family of proteins. And it now seems that many inflammatory processes, both sterile and infectious, may depend on TLR signalling. We are in a good position to apply our understanding of TLR signalling to a range of challenges in immunology and medicine. Inferences, questions and possibilities in Toll-like receptor signalling. B Beutler doi:10.1038/nature02761 Nature, Vol. 430, No. 6996. (8 July 2004), pp. 257-263. 2006-01-23T01:05:34-00:00 2004 Nature 1476-4687 430 6996 257 263 tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/216164 <i>Nature Reviews Immunology, Vol. 5, No. 6. (01 June 2005), pp. 446-458.</i> Negative regulation of Toll-like receptor-mediated immune responses Foo Liew Damo Xu Elizabeth Brint Luke O'Neill doi:10.1038/nri1630 Nature Reviews Immunology, Vol. 5, No. 6. (01 June 2005), pp. 446-458. 2005-06-01T20:15:43-00:00 2005 Nature Reviews Immunology 1474-1733 5 6 446 458 Nature Publishing Group tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1119389 <i>Nature Reviews Immunology, Vol. 7, No. 3., pp. 179-190.</i> Cooperation of Toll-like receptor signals in innate immune defence Giorgio Trinchieri Alan Sher doi:10.1038/nri2038 Nature Reviews Immunology, Vol. 7, No. 3., pp. 179-190. 2007-02-23T22:17:07-00:00 Nature Reviews Immunology 1474-1733 7 3 179 190 Nature Publishing Group tlr-signaling http://www.citeulike.org/user/AlfonsoVicenteSuarez/article/1343555 <i>Nat Immunol, Vol. 4, No. 2. (February 2003), pp. 105-106.</i> Toll signaling: the TIReless quest for specificity Jean-Luc Imler Jules Hoffmann doi:10.1038/ni0203-105 Nat Immunol, Vol. 4, No. 2. (February 2003), pp. 105-106. 2007-05-30T16:01:31-00:00 2003 Nat Immunol 4 2 105 106 tlr-signaling