Thu, 24 Jul 2008 23:47:02 BST CiteULike: Xavier's Treangen http://www.citeulike.org/user/Xavier/author/Treangen CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/Xavier/article/2640930 <i>Methods in molecular biology (Clifton, N.J.), Vol. 396 (2007), pp. 135-152.</i><br /><br />During the course of evolution, genomes can undergo large-scale mutation events such as rearrangement and lateral transfer. Such mutations can result in significant variations in gene order and gene content among otherwise closely related organisms. The Mauve genome alignment system can successfully identify such rearrangement and lateral transfer events in comparisons of multiple microbial genomes even under high levels of recombination. This chapter outlines the main features of Mauve and provides examples that describe how to use Mauve to conduct a rigorous multiple genome comparison and study evolutionary patterns. Analyzing patterns of microbial evolution using the mauve genome alignment system. AE Darling TJ Treangen X Messeguer NT Perna Methods in molecular biology (Clifton, N.J.), Vol. 396 (2007), pp. 135-152. 2008-04-08T08:45:04-00:00 2007 Methods in molecular biology (Clifton, N.J.) 1064-3745 396 135 152 no-tag