Thu, 21 Aug 2008 15:29:38 BST CiteULike: apeyrache's Fanselow http://www.citeulike.org/user/apeyrache/author/Fanselow CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/apeyrache/article/2760259 <i>Learning & memory (Cold Spring Harbor, N.Y.), Vol. 15, No. 5. (2008), pp. 368-372.</i><br /><br />Retrograde amnesia following disruptions of hippocampal function is often temporally graded, with recent memories being more impaired. Evidence supports the existence of one or more neocortical long-term memory storage/retrieval site(s). Neurotoxic lesions of the medial prefrontal cortex (mPFC) or the dorsal hippocampus (DH) were made 1 day or 200 days following trace fear conditioning. Recently encoded trace fear memories were most disrupted by DH lesions, while remotely encoded trace and contextual memories were most disrupted by mPFC lesions. These data strongly support the consolidation theory of hippocampus function and implicate the mPFC as a site of long-term memory storage/retrieval. Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories. JJ Quinn QD Ma MR Tinsley C Koch MS Fanselow doi:10.1101/lm.813608 Learning & memory (Cold Spring Harbor, N.Y.), Vol. 15, No. 5. (2008), pp. 368-372. 2008-05-06T09:02:12-00:00 2008 Learning & memory (Cold Spring Harbor, N.Y.) 1549-5485 15 5 368 372 consolidation hippocampus pfc