Thu, 24 Jul 2008 23:43:18 BST CiteULike: awooga's library [656 articles] http://www.citeulike.org/user/awooga/article/2567765 CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/awooga/article/2567765 <i>Proc Natl Acad Sci U S A, Vol. 99, No. 16. (6 August 2002), pp. 10831-10836.</i><br /><br />Synapses in the brain are bidirectionally modifiable, but the routes of induction are diverse. In various experimental paradigms, N-methyl-d-aspartate receptor-dependent long-term depression and long-term potentiation have been induced selectively by varying the membrane potential of the postsynaptic neurons during presynaptic stimulation of a constant frequency, the rate of presynaptic stimulation, and the timing of pre- and postsynaptic action potentials. In this paper, we present a mathematical embodiment of bidirectional synaptic plasticity that is able to explain diverse induction protocols with a fixed set of parameters. The key assumptions and consequences of the model can be tested experimentally; further, the model provides the foundation for a unified theory of N-methyl-d-aspartate receptor-dependent synaptic plasticity. A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. HZ Shouval MF Bear LN Cooper doi:10.1073/pnas.152343099 Proc Natl Acad Sci U S A, Vol. 99, No. 16. (6 August 2002), pp. 10831-10836. 2008-03-20T17:42:30-00:00 2002 Proc Natl Acad Sci U S A 0027-8424 99 16 10831 10836 no-tag