Thu, 21 Aug 2008 15:32:36 BST CiteULike: awooga's Sjostrom http://www.citeulike.org/user/awooga/author/Sjostrom CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/awooga/article/2558158 <i>Neuron, Vol. 32, No. 6. (20 December 2001), pp. 1149-1164.</i><br /><br />Cortical long-term plasticity depends on firing rate, spike timing, and cooperativity among inputs, but how these factors interact during realistic patterns of activity is unknown. Here we monitored plasticity while systematically varying the rate, spike timing, and number of coincident afferents. These experiments demonstrate a novel form of cooperativity operating even when postsynaptic firing is evoked by current injection, and reveal a complex dependence of LTP and LTD on rate and timing. Based on these data, we constructed and tested three quantitative models of cortical plasticity. One of these models, in which spike-timing relationships causing LTP "win" out over those favoring LTD, closely fits the data and accurately predicts the build-up of plasticity during random firing. This provides a quantitative framework for predicting the impact of in vivo firing patterns on synaptic strength. Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity Per Sjostrom Gina Turrigiano Sacha Nelson doi:10.1016/S0896-6273(01)00542-6 Neuron, Vol. 32, No. 6. (20 December 2001), pp. 1149-1164. 2008-03-19T11:19:26-00:00 2001 Neuron 32 6 1149 1164 no-tag http://www.citeulike.org/user/awooga/article/2558159 <i>Current Opinion in Neurobiology, Vol. 12, No. 3. (1 June 2002), pp. 305-314.</i><br /><br />Plasticity at central synapses depends critically on the timing of presynaptic and postsynaptic action potentials. Key initial steps in synaptic plasticity involve the back-propagation of action potentials into the dendritic tree and calcium influx that depends nonlinearly on the action potential and synaptic input. These initial steps are now better understood. In addition, recent studies of processes as diverse as gene expression and channel inactivation suggest that responses to calcium transients depend not only their amplitude, but on their time course and on the location of their origin. Spike timing, calcium signals and synaptic plasticity Per Sjostrom Sacha Nelson doi:10.1016/S0959-4388(02)00325-2 Current Opinion in Neurobiology, Vol. 12, No. 3. (1 June 2002), pp. 305-314. 2008-03-19T11:19:32-00:00 2002 Current Opinion in Neurobiology 12 3 305 314 calcium model plasticity review