Thu, 07 Aug 2008 21:47:51 BST CiteULike: brembs's Guo http://www.citeulike.org/user/brembs/author/Guo CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/brembs/article/3063294 <i>Science, Vol. 316, No. 5833. (2007), 1901-1904.</i><br /><br />Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila. Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila Ke Zhang Jian Guo Yueqing Peng Wang Xi Aike Guo doi:10.1126/science.1137357 Science, Vol. 316, No. 5833. (2007), 1901-1904. 2008-07-30T12:58:27-00:00 2007 Science 316 5833 1901-1904 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3063269 <i>Physiology and Behavior, Vol. 62, No. 2. (1997), 263-271.</i> Nutritional effects on operant visual learning in Drosophila melanogaster SZ Xia L Liu CH Feng AK Guo Physiology and Behavior, Vol. 62, No. 2. (1997), 263-271. 2008-07-30T12:58:21-00:00 1997 Physiology and Behavior 62 2 263-271 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3063268 <i>Learning and Memory, Vol. 4, No. 2. (1997), 205-218.</i> Memory consolidation in Drosophila operant visual learning SZ Xia L Liu CH Feng A Guo Learning and Memory, Vol. 4, No. 2. (1997), 205-218. 2008-07-30T12:58:20-00:00 1997 Learning and Memory 4 2 205-218 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3063267 <i>Physiology and Behavior, Vol. 65, No. 4-5. (1999), 617-623.</i> Temporary amnesia induced by cold anesthesia and hypoxia in Drosophila SZ Xia CH Feng AK Guo Physiology and Behavior, Vol. 65, No. 4-5. (1999), 617-623. 2008-07-30T12:58:20-00:00 1999 Physiology and Behavior 65 4-5 617-623 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3063170 <i>Science in China Series C Life Sciences, Vol. 41, No. 5. (1998), 503-511.</i> Relationship between visual learning/memory ability and brain cAMP level in Drosophila X Wang L Liu SZ Xia CH Feng A Guo Science in China Series C Life Sciences, Vol. 41, No. 5. (1998), 503-511. 2008-07-30T12:58:06-00:00 1998 Science in China Series C Life Sciences 41 5 503-511 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3063169 <i>Behav Processes, Vol. 64, No. 1. (2003), 57-70.</i><br /><br />Ever since operant conditioning was studied experimentally, the relationship between associative learning and possible motor learning has become controversial. Although motor learning and its underlying neural substrates have been extensively studied in mammals, it is still poorly understood in invertebrates. The visual discriminative avoidance paradigm of Drosophila at the flight simulator has been widely used to study the flies' visual associative learning and related functions, but it has not been used to study the motor learning process. In this study, newly-designed data analysis was employed to examine the flies' solitary behavioural variable that was recorded at the flight simulator-yaw torque. Analysis was conducted to explore torque distributions of both wild-type and mutant flies in conditioning, with the following results: (1) Wild-type Canton-S flies had motor learning performance in conditioning, which was proved by modifications of the animal's behavioural mode in conditioning. (2) Repetition of training improved the motor learning performance of wild-type Canton-S flies. (3) Although mutant dunce(1) flies were defective in visual associative learning, they showed essentially normal motor learning performance in terms of yaw torque distribution in conditioning. Finally, we tentatively proposed that both visual associative learning and motor learning were involved in the visual operant conditioning of Drosophila at the flight simulator, that the two learning forms could be dissociated and they might have different neural bases. Dissociation of visual associative and motor learning in Drosophila at the flight simulator S Wang Y Li C Feng A Guo Behav Processes, Vol. 64, No. 1. (2003), 57-70. 2008-07-30T12:58:06-00:00 2003 Behav Processes 64 1 57-70 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3063044 <i>Science, Vol. 294, No. 5546. (2001), 1543-1547.</i> Choice Behavior of Drosophila Facing Contradictory Visual Cues Shiming Tang Aike Guo Science, Vol. 294, No. 5546. (2001), 1543-1547. 2008-07-30T12:57:48-00:00 2001 Science 294 5546 1543-1547 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3062371 <i>Pharmacology Biochemistry and Behavior, Vol. 61, No. 4. (1998), 349-355.</i> Conditioned visual flight orientation in Drosophila melanogaster abolished by benzaldehyde L Liu X Wang SZ Xia CH Feng A Guo Pharmacology Biochemistry and Behavior, Vol. 61, No. 4. (1998), 349-355. 2008-07-30T12:56:10-00:00 1998 Pharmacology Biochemistry and Behavior 61 4 349-355 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3062018 <i>Science, Vol. 309, No. 5732. (2005), 307-310.</i><br /><br />Different modalities of sensation interact in a synergistic or antagonistic manner during sensory perception, but whether there is also interaction during memory acquisition is largely unknown. In Drosophila reinforcement learning, we found that conditioning with concurrent visual and olfactory cues reduced the threshold for unimodal memory retrieval. Furthermore, bimodal preconditioning followed by unimodal conditioning with either a visual or olfactory cue led to crossmodal memory transfer. Crossmodal memory acquisition in Drosophila may contribute significantly to learning in a natural environment. Crossmodal Interactions Between Olfactory and Visual Learning in Drosophila Jianzeng Guo Aike Guo Science, Vol. 309, No. 5732. (2005), 307-310. 2008-07-30T12:55:00-00:00 2005 Science 309 5732 307-310 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3062017 <i>Learning and Memory, Vol. 3 (1996), 49-59.</i> Conditioned visual flight orientation in Drosophila; Dependence on age, practice and diet A Guo L Liu SZ Xia CH Feng R Wolf M Heisenberg Learning and Memory, Vol. 3 (1996), 49-59. 2008-07-30T12:55:00-00:00 1996 Learning and Memory 3 49-59 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3062016 <i>Learning and Memory, Vol. 4, No. 2. (1997), 192-204.</i> Association of visual objects and olfactory cues in Drosophila A Guo KG Götz Learning and Memory, Vol. 4, No. 2. (1997), 192-204. 2008-07-30T12:55:00-00:00 1997 Learning and Memory 4 2 192-204 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/3061978 <i>J Insect Physiol, Vol. 44, No. 12. (1998), 1149-1158.</i><br /><br />Learning and memory of Drosophila mutants dunce, amnesiac and radish which were isolated originally from the classical olfactory learning paradigm are analyzed in an operant visual learning paradigm. Dunce appears to show normal ability to learn during training, but its memory is significantly affected. Though the learning index during the first minute after training is normal, its short-term memory (STM), anesthesia-resistant memory (ARM) and long-term memory (LTM) are all significantly damaged. Amnesiac displays disrupted middle-term memory (MTM), while its STM and LTM remain unchanged. Learning and memory in radish mutants seem to be unaffected. These results lend support to the argument that there are certain common molecular mechanisms underlying learning and memory through different tasks and the previous multi-phase model of visual memory is modified in a genetic way. Operant visual learning and memory in Drosophila mutants dunce, amnesiac and radish Z Gong S Xia L Liu C Feng A Guo J Insect Physiol, Vol. 44, No. 12. (1998), 1149-1158. 2008-07-30T12:54:55-00:00 1998 J Insect Physiol 44 12 1149-1158 file-import-08-07-30 http://www.citeulike.org/user/brembs/article/1421811 <i>Science, Vol. 316, No. 5833. (29 June 2007), pp. 1901-1904.</i><br /><br />Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila. 10.1126/science.1137357 Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila Ke Zhang Jian Guo Yueqing Peng Wang Xi Aike Guo doi:10.1126/science.1137357 Science, Vol. 316, No. 5833. (29 June 2007), pp. 1901-1904. 2007-06-29T08:23:23-00:00 2007 Science 316 5833 1901 1904 bodies decision-making drosophila learning memory mushroom visual