CiteULike: brembs's decision-making http://www.citeulike.org/user/brembs/tag/decision-making CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/brembs/article/1206070 <i>Trends in Neurosciences, Vol. In Press, Corrected Proof</i><br /><br />There are several brain regions that have been implicated in the control of motivated behavior and whose disruption leads to the pathophysiology observed in major psychiatric disorders. These systems include the ventral hippocampus, which is involved in context and focus on tasks, the amygdala, which mediates emotional behavior, and the prefrontal cortex, which modulates activity throughout the limbic system to enable behavioral flexibility. Each of these systems has overlapping projections to the nucleus accumbens, where these inputs are integrated under the modulatory influence of dopamine. Here, we provide a systems-oriented approach to interpreting the function of the dopamine system, its modulation of limbic-cortical interactions and how disruptions within this system might underlie the pathophysiology of schizophrenia and drug abuse. Regulation of firing of dopaminergic neurons and control of goal-directed behaviors Anthony Grace Stan Floresco Yukiori Goto Daniel Lodge doi:10.1016/j.tins.2007.03.003 Trends in Neurosciences, Vol. In Press, Corrected Proof 2007-04-04T14:05:09-00:00 Trends in Neurosciences In Press, Corrected Proof behavior decision-making habit instrumental learning neurobiology neuroscience operant psychology http://www.citeulike.org/user/brembs/article/80546 <i>PLoS One, Vol. 2, No. 5. (May 2007), e443.</i> Order in spontaneous behavior Alexander Maye Chih-Hao Hsieh George Sugihara Björn Brembs PLoS One, Vol. 2, No. 5. (May 2007), e443. 2005-01-20T00:29:54-00:00 PLoS One 2 5 e443 behavior decision-making drosophila flies invertebrate neurobiology neuroscience predator-avoidance psychology http://www.citeulike.org/user/brembs/article/1421811 <i>Science, Vol. 316, No. 5833. (29 June 2007), pp. 1901-1904.</i><br /><br />Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila. 10.1126/science.1137357 Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila Ke Zhang Jian Guo Yueqing Peng Wang Xi Aike Guo doi:10.1126/science.1137357 Science, Vol. 316, No. 5833. (29 June 2007), pp. 1901-1904. 2007-06-29T08:23:23-00:00 Science 316 5833 1901 1904 bodies decision-making drosophila learning memory mushroom visual