CiteULike: carmenv's ampk http://www.citeulike.org/user/carmenv/tag/ampk CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/carmenv/article/2776585 <i>Molecular carcinogenesis (30 April 2008)</i><br /><br />Considerable evidence has demonstrated that UVB irradiation is a strong carcinogen for nonmelanoma skin cancer. Up-regulation of cyclooxygenase -2 (Cox-2) has been shown to be a crucial event in human keratinocytes in their responses to UVB irradiation. To further understand the molecular mechanisms governing Cox-2 regulation, we found that UVB irradiation significantly increased Cox-2 mRNA stability by inducing cytoplasmic localization and protein abundance of human antigen R (HuR). We also found that AMP-activated kinase (AMPK) mediates these events and that UVB reduces AMPK activity by down-regulating LKB1 kinase. Finally, we propose a novel model in which UVB regulates Cox-2 mRNA stability through the LKB1/AMPK pathway. (c) 2008 Wiley-Liss, Inc. UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes. Jack Zhang G Tim Bowden doi:10.1002/mc.20450 Molecular carcinogenesis (30 April 2008) 2008-05-09T20:34:34-00:00 Molecular carcinogenesis 1098-2744 ampk keratinocytes