Sat, 05 Jul 2008 12:57:47 BST CiteULike: emptyhb's noiserobustness http://www.citeulike.org/user/emptyhb/tag/noiserobustness CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/emptyhb/article/386210 <i>Nature, Vol. 438, No. 7065., pp. 220-223.</i> A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression Scott Rifkin David Houle Junhyong Kim Kevin White doi:10.1038/nature04114 Nature, Vol. 438, No. 7065., pp. 220-223. 2005-11-10T04:45:11-00:00 Nature 0028-0836 438 7065 220 223 Nature Publishing Group expression noiserobustness http://www.citeulike.org/user/emptyhb/article/2836281 <i>Mathematical Biosciences, Vol. In Press, Corrected Proof</i><br /><br />Conventional population genetics considers the evolution of a limited number of genotypes corresponding to phenotypes with different fitness. As model phenotypes, in particular RNA secondary structure, have become computationally tractable, however, it has become apparent that the context dependent effect of mutations and the many-to-one nature inherent in these genotype-phenotype maps can have fundamental evolutionary consequences. It has previously been demonstrated that populations of genotypes evolving on the neutral networks corresponding to all genotypes with the same secondary structure only through neutral mutations can evolve mutational robustness [E. van Nimwegen, J.P. Crutchfield, M. Huynen, Neutral evolution of mutational robustness, Proc. Natl. Acad. Sci. USA 96(17), 9716-9720 (1999)], by concentrating the population on regions of high neutrality. Introducing recombination we demonstrate, through numerically calculating the stationary distribution of an infinite population on ensembles of random neutral networks that mutational robustness is significantly enhanced and further that the magnitude of this enhancement is sensitive to details of the neutral network topology. Through the simulation of finite populations of genotypes evolving on random neutral networks and a scaled down microRNA neutral network, we show that even in finite populations recombination will still act to focus the population on regions of locally high neutrality. The effect of recombination on the neutral evolution of genetic robustness Gergely Szöllosi Imre Derényi doi:10.1016/j.mbs.2008.03.010 Mathematical Biosciences, Vol. In Press, Corrected Proof 2008-05-27T00:42:37-00:00 Mathematical Biosciences In Press, Corrected Proof noiserobustness population_genetics_modeling http://www.citeulike.org/user/emptyhb/article/127086 <i>Science, Vol. 304, No. 5678. (18 June 2004), pp. 1811-1814.</i><br /><br />Noise, or random fluctuations, in gene expression may produce variability in cellular behavior. To measure the noise intrinsic to eukaryotic gene expression, we quantified the differences in expression of two alleles in a diploid cell. We found that such noise is gene-specific and not dependent on the regulatory pathway or absolute rate of expression. We propose a model in which the balance between promoter activation and transcription influences the variability in messenger RNA levels. To confirm the predictions of our model, we identified both cis- and trans-acting mutations that alter the noise of gene expression. These mutations suggest that noise is an evolvable trait that can be optimized to balance fidelity and diversity in eukaryotic gene expression. Control of stochasticity in eukaryotic gene expression. JM Raser EK O'Shea doi:10.1126/science.1098641 Science, Vol. 304, No. 5678. (18 June 2004), pp. 1811-1814. 2005-03-15T04:35:29-00:00 2004 Science 1095-9203 304 5678 1811 1814 cis_regulatory_elements noiserobustness transcriptional_regulation