Sun, 27 Jul 2008 08:11:46 BST CiteULike: heliopais's library [479 articles] http://www.citeulike.org/user/heliopais/article/1342108 CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/heliopais/article/1342108 <i>Drug Discov Today, Vol. 12, No. 11-12. (June 2007), pp. 452-458.</i><br /><br />Recently, microRNAs (miRNAs) have been shown to be important regulators of genes in many organisms and have already been implicated in a growing number of diseases. MiRNAs are short (21-23 nucleotides) RNAs that bind to the 3' untranslated regions of target genes. This binding event causes translational repression of the target gene and, evidence now suggests, also stimulates rapid degradation of the target transcript. miRNAs represent a new species of regulator, controlling the levels of potentially large numbers of proteins, many of which might be important drug targets. The expression of miRNAs shows that they are highly differentially expressed, with specific miRNAs active in certain tissues at certain times. In many cancers, miRNA expression is significantly altered, and this has been shown to be a useful diagnostic tool. Several computational approaches have been developed for the prediction of miRNA targets. Prediction of microRNA targets. P Mazière AJ Enright doi:10.1016/j.drudis.2007.04.002 Drug Discov Today, Vol. 12, No. 11-12. (June 2007), pp. 452-458. 2007-05-30T07:26:25-00:00 2007 Drug Discov Today 1359-6446 12 11-12 452 458 microrna microrna_target_prediction review