Thu, 21 Aug 2008 14:59:29 BST CiteULike: inesdesantiago's Fraga http://www.citeulike.org/user/inesdesantiago/author/Fraga CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/inesdesantiago/article/2311496 <i>Oncogene, Vol. aop, No. current.</i> Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins L Lopez-Serra E Ballestar S Ropero F Setien LM Billard MF Fraga P Lopez-Nieva M Alaminos D Guerrero R Dante M Esteller doi:10.1038/sj.onc.1211022 Oncogene, Vol. aop, No. current. 2008-01-31T12:00:12-00:00 Oncogene 0950-9232 aop current Nature Publishing Group methylation http://www.citeulike.org/user/inesdesantiago/article/2257911 <i>Proceedings of the National Academy of Sciences, Vol. 102, No. 30. (26 July 2005), pp. 10604-10609.</i><br /><br />Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. 10.1073/pnas.0500398102 From The Cover: Epigenetic differences arise during the lifetime of monozygotic twins Mario Fraga Esteban Ballestar Maria Paz Santiago Ropero Fernando Setien Maria Ballestar Damia Heine-Suner Juan Cigudosa Miguel Urioste Javier Benitez Manuel Boix-Chornet Abel Sanchez-Aguilera Charlotte Ling Emma Carlsson Pernille Poulsen Allan Vaag Zarko Stephan Tim Spector Yue-Zhong Wu Christoph Plass Manel Esteller doi:10.1073/pnas.0500398102 Proceedings of the National Academy of Sciences, Vol. 102, No. 30. (26 July 2005), pp. 10604-10609. 2008-01-19T19:39:44-00:00 2005 Proceedings of the National Academy of Sciences 102 30 10604 10609 methylation http://www.citeulike.org/user/inesdesantiago/article/1394954 <i>Trends Genet (6 June 2007)</i><br /><br />'Aging epigenetics' is an emerging field that promises exciting revelations in the near future. Here we focus on the functional and biological significance of the epigenetic alterations that accumulate during aging and are important in tumorigenesis. Paradigmatic examples are provided by the global loss of DNA methylation in aging and cancer and by the promoter hypermethylation of genes with a dual role in tumor suppression and progeria, such as the Werner syndrome (WRN) and lamin A/C genes. Another twist is provided by sirtuins, a family of NAD-dependent deacetylases that act on Lys16 of histone H4, which are emerging as a link between cellular transformation and lifespan. Epigenetics and aging: the targets and the marks. Mario Fraga Manel Esteller doi:10.1016/j.tig.2007.05.008 Trends Genet (6 June 2007) 2007-06-17T11:02:31-00:00 2007 Trends Genet 0168-9525 cancer review