CiteULike: jillhuang's library [118 articles]

Temporally selective attention modulates early perceptual processing: event-related potential evidence.

LD Sanders — 2008-07-02T18:51:20-00:00

Perception & psychophysics, Vol. 70, No. 4. (May 2008), pp. 732-742.

Some of the most important information we encounter changes so rapidly that our perceptual systems cannot process all of it in detail. Spatially selective attention is critical for perception when more information than can be processed in detail is presented simultaneously at distinct locations. When presented with complex, rapidly changing information, listeners may need to selectively attend to specific times rather than to locations. We present evidence that listeners can direct selective attention to time points that differ by as little as 500 msec, and that doing so improves target detection, affects baseline neural activity preceding stimulus presentation, and modulates auditory evoked potentials at a perceptually early stage. These data demonstrate that attentional modulation of early perceptual processing is temporally precise and that listeners can flexibly allocate temporally selective attention over short intervals, making it a viable mechanism for preferentially processing the most relevant segments in rapidly changing streams.

Anticipatory suppression of nonattended locations in visual cortex marks target location and predicts perception.

CM Sylvester — 2008-07-02T16:31:13-00:00

The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, No. 26. (25 June 2008), pp. 6549-6556.

Spatial attention is associated with modulations in prestimulus, anticipatory blood oxygen level-dependent (BOLD) activity across the brain. It is unclear, however, if these anticipatory modulations depend on the computational demands of the upcoming task. Here, we show that anticipation of low-contrast stimuli, relative to high-contrast stimuli, is associated with increased prestimulus BOLD activity in the frontal eye field (FEF) and the posterior inferior frontal sulcus (IFS) but not in the intraparietal sulcus (IPS). In visual cortex, anticipation of low-contrast stimuli is associated with increased suppression of activity corresponding to unattended (but not attended) locations, and this suppression predicts whether subjects will accurately perceive low-contrast stimuli. These results suggest that when a stimulus will be difficult to distinguish from the background, top-down signals from FEF and IFS can facilitate perception by marking its location through the suppression of unattended locations in visual cortex.

Prefrontal Cortex Function in the Representation of Temporally Complex Events

Philip Browning — 2008-04-09T21:16:04-00:00

J. Neurosci., Vol. 28, No. 15. (9 April 2008), pp. 3934-3940.

The frontal cortex and inferior temporal cortex are strongly functionally interconnected. Previous experiments on prefrontal function in monkeys have shown that a disconnection of prefrontal cortex from inferior temporal cortex impairs a variety of complex visual learning tasks but leaves simple concurrent objectreward association learning intact. We investigated the possibility that temporal components of visual learning tasks determine the sensitivity of those tasks to prefrontaltemporal disconnection by adding specific temporal components to the concurrent objectreward association learning task. Monkeys with crossed unilateral lesions of prefrontal cortex and inferior temporal cortex were impaired compared with unoperated controls at associating two-item sequences of visual objects with reward. The impairment was specific to the learning of visual sequences, because disconnection was without effect on objectreward association learning for an equivalent delayed reward. This result was replicated in monkeys with transection of the uncinate fascicle, thus determining the anatomical specificity of the dissociation. Previous behavioral results suggest that monkeys represent the two-item serial compound stimuli in a configural manner, similar to the way monkeys represent simultaneously presented compound stimuli. The representation of simultaneously presented configural stimuli depends on the perirhinal cortex. The present experiments show that the representation of serially presented compound stimuli depends on the interaction of prefrontal cortex and inferior temporal cortex. We suggest that prefrontaltemporal disconnection impairs a wide variety of learning tasks because in those tasks monkeys lay down similar temporally complex representations. 10.1523/JNEUROSCI.0633-08.2008

Maps of visual space in human occipital cortex are retinotopic, not spatiotopic.

JL Gardner — 2008-04-16T15:14:36-00:00

The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, No. 15. (9 April 2008), pp. 3988-3999.

We experience the visual world as phenomenally invariant to eye position, but almost all cortical maps of visual space in monkeys use a retinotopic reference frame, that is, the cortical representation of a point in the visual world is different across eye positions. It was recently reported that human cortical area MT (unlike monkey MT) represents stimuli in a reference frame linked to the position of stimuli in space, a "spatiotopic" reference frame. We used visuotopic mapping with blood oxygen level-dependent functional magnetic resonance imaging signals to define 12 human visual cortical areas, and then determined whether the reference frame in each area was spatiotopic or retinotopic. We found that all 12 areas, including MT, represented stimuli in a retinotopic reference frame. Although there were patches of cortex in and around these visual areas that were ostensibly spatiotopic, none of these patches exhibited reliable stimulus-evoked responses. We conclude that the early, visuotopically organized visual cortical areas in the human brain (like their counterparts in the monkey brain) represent stimuli in a retinotopic reference frame.

Visual short-term memory operates more efficiently on boundary features than on surface features.

GA Alvarez — 2008-04-02T14:53:55-00:00

Perception & psychophysics, Vol. 70, No. 2. (February 2008), pp. 346-364.

A change detection task was used to estimate the visual short-term memory storage capacity for either the orientation or the size of objects. On each trial, several,objects were briefly presented, followed by a blank interval and then by a second display of objects that either was identical to the first display or had a single object that was different (the object changed either orientation or size, in separate experiments). The task was to indicate whether the two displays were the same or different, and the number of objects remembered was estimated from the percent correct on this task. Storage capacity for a feature was nearly twice as large when that feature was defined by the object boundary, rather than by the surface texture of the object. This dramatic difference in storage capacity suggests that a particular feature (e.g., right tilted or small) is not stored in memory with an invariant abstract code. Instead, there appear to be different codes for the boundary and surface features of objects, and memory operates on boundary features more efficiently than it operates on surface features.

Precuing benefits for color and location in a visual search task.

E Vierck — 2008-04-02T14:51:18-00:00

Perception & psychophysics, Vol. 70, No. 2. (February 2008), pp. 365-373.

Selection in multiple-item displays has been shown to benefit immensely from advance knowledge of target location (e.g., Henderson, 1991), leading to the suggestion that location is completely dominant in visual selective attention (e.g., Tsal & Lavie, 1993). Recently, direct selection by color has been reported in displays in which location does not vary (Vierck & Miller, 2005). The present experiment investigated the possibility of independent selection by color in a task with multiple-item displays and location precues in order to see whether color is also used for selection even when target location does vary and supposedly dominant location precues can be used. Precues provided independent information about the location and color of a target, and each type of precue could be either valid or invalid. The precues were followed by brief displays of six letters in six different colors, and participants had to discriminate the case of a prespecified target letter (e.g., R vs. r). Performance was much better when location cues were valid than when they were invalid, confirming the large advantage associated with valid advance location information. Performance was also better with valid advance color information, however, both when location cues were valid and when they were invalid. But these color benefits were dependent on the closeness of the colored letter to the cued location. Our results thus suggest that selection by color in a multiple-item display, where location and color information are independent from each other and equalized, is mediated by location information.

Does attention move or spread during mental curve tracing?

D Crundall — 2008-04-02T14:45:43-00:00

Perception & psychophysics, Vol. 70, No. 2. (February 2008), pp. 374-388.

There are two theories that attempt to explain how attention is deployed when lines are traced. Initially, it was believed that a covert zoom lens moved along the line. Recent evidence has, however, suggested that attention spreads along the line, rather than moving along it, perhaps as part of an effortful object-parsing process. Three experiments tested the spreading and moving accounts of line tracing. Participants were presented with two intertwined lines and were required to trace one to find the correct target. On half the trials, a masked change occurred, most often near the top of the target line, that reversed the required response. If attention spreads along the line, the participants should have been able to notice the change whenever it occurred during the tracing process. However, the participants found it harder to spot the change if it occurred late in the tracing process. This suggests that resources were less frequently available to detect changes on portions of the line that had already been traced when the change occurred. The results argue against a spreading trace of attention that encompasses the whole line.

Saccade Target Selection in the Superior Colliculus: A Signal Detection Theory Approach

Byounghoon Kim — 2008-03-19T17:48:10-00:00

J. Neurosci., Vol. 28, No. 12. (19 March 2008), pp. 2991-3007.

How the brain selects one action from among multiple options is unknown. A main tenet of signal detection theory (SDT) is that sensory stimuli are represented as noisy information channels. Therefore, the accuracy of selection might be predicted by how well neuronal activity representing alternatives can be distinguished. Here, we apply an SDT framework to a motor system by recording from superior colliculus (SC) neurons during performance of a color, oddball selection task. We recorded from sets of four neurons simultaneously, each of the four representing one of the four possible targets. Because the electrode placement constrained the position of the stimuli in the visual field, the stimulus arrangement varied across experiments. This variability in stimulus arrangement led to variability in choices allowing us to explore the relationship between SC neuronal activity and performance accuracy. SC target neurons had higher levels of discharge than SC distractor neurons in subsets of trials when selection performance was very accurate. In subsets of trials when performance was poor, the discharge level decreased in target neurons and increased in distractor neurons. Accurate performance was associated with larger separations between neuronal activity from targets and distractors as quantified by the receiver operating characteristic (ROC) area and d' (an index of discriminability). Poorer performance was associated with less separation of target and distractor neuronal activity. ROC area and d' scaled approximately linearly with performance accuracy. Furthermore, ROC area and d' increased as saccade onset approached. Together, the results indicate that SC buildup neuronal activity signals the saccadic eye movement decision. 10.1523/JNEUROSCI.5424-07.2008

Bounded Integration in Parietal Cortex Underlies Decisions Even When Viewing Duration Is Dictated by the Environment

Roozbeh Kiani — 2008-03-19T18:16:47-00:00

J. Neurosci., Vol. 28, No. 12. (19 March 2008), pp. 3017-3029.

Decisions about sensory stimuli are often based on an accumulation of evidence in time. When subjects control stimulus duration, the decision terminates when the accumulated evidence reaches a criterion level. Under many natural circumstances and in many laboratory settings, the environment, rather than the subject, controls the stimulus duration. In these settings, it is generally assumed that subjects commit to a choice at the end of the stimulus stream. Indeed, failure to benefit from the full stream of information is interpreted as a sign of imperfect accumulation or memory leak. Contrary to these assumptions, we show that monkeys performing a direction discrimination task commit to a choice when the accumulated evidence reaches a threshold level (or bound), sometimes long before the end of stimulus. This bounded accumulation of evidence is reflected in the activity of neurons in the lateral intraparietal cortex. Thus, the readout of visual cortex embraces a termination rule to limit processing even when potentially useful information is available. 10.1523/JNEUROSCI.4761-07.2008

What Aspect of Handedness is General Motor Programming Related To?

AM Keane — 2008-03-10T16:19:10-00:00

Int J Neurosci, Vol. 118, No. 4. (April 2008), pp. 519-530.

As general motor programming had previously been found to be related to consistency of hand preference (Keane, 1999), the present study attempted to elucidate what general motor programming involves by reinvestigating responses to the Edinburgh Handedness Inventory in order to see if there was some consensus with regards to the items that tended to differentiate the consistent handers from the inconsistent handers. It was found that the opening a box item did differentiate the consistent handers from the inconsistent handers. Control of this type of bimanual task seems to be specifically related to the general motor programmer, and not hand preference as such.

Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.

S Nuber — 2008-03-10T16:15:28-00:00

J Neurosci, Vol. 28, No. 10. (5 March 2008), pp. 2471-2484.

Alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease. These disorders are characterized by various neurological and psychiatric symptoms based on progressive neuropathological alterations. Whether the neurodegenerative process might be halted or even reversed is presently unknown. Therefore, conditional mouse models are powerful tools to analyze the relationship between transgene expression and progression of the disease. To explore whether alpha-syn solely originates and further incites these alterations, we generated conditional mouse models by using the tet-regulatable system. Mice expressing high levels of human wild-type alpha-syn in midbrain and forebrain regions developed nigral and hippocampal neuropathology, including reduced neurogenesis and neurodegeneration in absence of fibrillary inclusions, leading to cognitive impairment and progressive motor decline. Turning off transgene expression in symptomatic mice halted progression but did not reverse the symptoms. Thus, our data suggest that approaches targeting alpha-syn-induced pathological pathways might be of benefit rather in early disease stages. Furthermore, alpha-syn-associated cytotoxicity is independent of filamentous inclusion body formation in our conditional mouse model.

A Hierarchy of Temporal Receptive Windows in Human Cortex

Uri Hasson — 2008-03-06T09:31:12-00:00

J. Neurosci., Vol. 28, No. 10. (5 March 2008), pp. 2539-2550.

Real-world events unfold at different time scales and, therefore, cognitive and neuronal processes must likewise occur at different time scales. We present a novel procedure that identifies brain regions responsive to sensory information accumulated over different time scales. We measured functional magnetic resonance imaging activity while observers viewed silent films presented forward, backward, or piecewise-scrambled in time. Early visual areas (e.g., primary visual cortex and the motion-sensitive area MT+) exhibited high response reliability regardless of disruptions in temporal structure. In contrast, the reliability of responses in several higher brain areas, including the superior temporal sulcus (STS), precuneus, posterior lateral sulcus (LS), temporal parietal junction (TPJ), and frontal eye field (FEF), was affected by information accumulated over longer time scales. These regions showed highly reproducible responses for repeated forward, but not for backward or piecewise-scrambled presentations. Moreover, these regions exhibited marked differences in temporal characteristics, with LS, TPJ, and FEF responses depending on information accumulated over longer durations ([~]36 s) than STS and precuneus ([~]12 s). We conclude that, similar to the known cortical hierarchy of spatial receptive fields, there is a hierarchy of progressively longer temporal receptive windows in the human brain. 10.1523/JNEUROSCI.5487-07.2008

Neural Dissociation between Visual Awareness and Spatial Attention

Valentin Wyart — 2008-03-05T18:35:01-00:00

J. Neurosci., Vol. 28, No. 10. (5 March 2008), pp. 2667-2679.

To what extent does what we consciously see depend on where we attend to? Psychologists have long stressed the tight relationship between visual awareness and spatial attention at the behavioral level. However, the amount of overlap between their neural correlates remains a matter of debate. We recorded magnetoencephalographic signals while human subjects attended toward or away from faint stimuli that were reported as consciously seen only half of the time. Visually identical stimuli could thus be attended or not and consciously seen or not. Although attended stimuli were consciously seen slightly more often than unattended ones, the factorial analysis of stimulus-induced oscillatory brain activity revealed distinct and independent neural correlates of visual awareness and spatial attention at different frequencies in the gamma range (30150 Hz). Whether attended or not, consciously seen stimuli induced increased mid-frequency gamma-band activity over the contralateral visual cortex, whereas spatial attention modulated high-frequency gamma-band activity in response to both consciously seen and unseen stimuli. A parametric analysis of the data at the single-trial level confirmed that the awareness-related mid-frequency activity drove the seenunseen decision but also revealed a small influence of the attention-related high-frequency activity on the decision. These results suggest that subjective visual experience is shaped by the cumulative contribution of two processes operating independently at the neural level, one reflecting visual awareness per se and the other reflecting spatial attention. 10.1523/JNEUROSCI.4748-07.2008

Identifying natural images from human brain activity : Article : Nature

Kendrick — 2008-03-06T20:47:00-00:00

Nature (5 March 2008)

A challenging goal in neuroscience is to be able to read out, or decode, mental content from brain activity. Recent functional magnetic resonance imaging (fMRI) studies have decoded orientation1, 2, position3 and object category4, 5 from activity in visual cortex. However, these studies typically used relatively simple stimuli (for example, gratings) or images drawn from fixed categories (for example, faces, houses), and decoding was based on previous measurements of brain activity evoked by those same stimuli or categories. To overcome these limitations, here we develop a decoding method based on quantitative receptive-field models that characterize the relationship between visual stimuli and fMRI activity in early visual areas. These models describe the tuning of individual voxels for space, orientation and spatial frequency, and are estimated directly from responses evoked by natural images. We show that these receptive-field models make it possible to identify, from a large set of completely novel natural images, which specific image was seen by an observer. Identification is not a mere consequence of the retinotopic organization of visual areas; simpler receptive-field models that describe only spatial tuning yield much poorer identification performance. Our results suggest that it may soon be possible to reconstruct a picture of a person's visual experience from measurements of brain activity alone.

Prestimulus oscillatory activity in the alpha band predicts visual discrimination ability.

H van Dijk — 2008-02-25T15:19:16-00:00

J Neurosci, Vol. 28, No. 8. (20 February 2008), pp. 1816-1823.

Although the resting and baseline states of the human electroencephalogram and magnetoencephalogram (MEG) are dominated by oscillations in the alpha band (approximately 10 Hz), the functional role of these oscillations remains unclear. In this study we used MEG to investigate how spontaneous oscillations in humans presented before visual stimuli modulate visual perception. Subjects had to report if there was a subtle difference in gray levels between two superimposed presented discs. We then compared the prestimulus brain activity for correctly (hits) versus incorrectly (misses) identified stimuli. We found that visual discrimination ability decreased with an increase in prestimulus alpha power. Given that reaction times did not vary systematically with prestimulus alpha power changes in vigilance are not likely to explain the change in discrimination ability. Source reconstruction using spatial filters allowed us to identify the brain areas accounting for this effect. The dominant sources modulating visual perception were localized around the parieto-occipital sulcus. We suggest that the parieto-occipital alpha power reflects functional inhibition imposed by higher level areas, which serves to modulate the gain of the visual stream.

Activation of the medial septum reverses age-related hippocampal encoding deficits: a place field analysis.

S Sava — 2008-02-25T15:16:18-00:00

J Neurosci, Vol. 28, No. 8. (20 February 2008), pp. 1841-1853.

When a rat runs through a familiar environment, the hippocampus retrieves a previously stored spatial representation of the environment. When the environment is modified a new representation is seen, presumably corresponding to the hippocampus encoding the new information. The medial septum is hypothesized to modulate whether the hippocampus engages in retrieval or encoding. The cholinergic agonist carbachol was infused into the medial septum, and hippocampal CA1 place cells were recorded in freely moving rats. In a familiar environment, septal activation impaired the retrieval of a previously stored hippocampal place cell representation regardless of age. When the environment was changed, medial septal activation impaired the encoding process in young, but facilitated the encoding of the new information in aged rats. Moreover, the improved encoding was evident during a subsequent exposure to the modified environment 24 h later. The findings support the role the septum plays in modulating hippocampal retrieval/encoding states. Furthermore, our data indicate a mechanism of age-related cognitive impairment.

Nonlinearities and Contextual Influences in Auditory Cortical Responses Modeled with Multilinear Spectrotemporal Methods

Misha Ahrens — 2008-02-21T09:23:33-00:00

J. Neurosci., Vol. 28, No. 8. (20 February 2008), pp. 1929-1942.

The relationship between a sound and its neural representation in the auditory cortex remains elusive. Simple measures such as the frequency response area or frequency tuning curve provide little insight into the function of the auditory cortex in complex sound environments. Spectrotemporal receptive field (STRF) models, despite their descriptive potential, perform poorly when used to predict auditory cortical responses, showing that nonlinear features of cortical response functions, which are not captured by STRFs, are functionally important. We introduce a new approach to the description of auditory cortical responses, using multilinear modeling methods. These descriptions simultaneously account for several nonlinearities in the stimulusresponse functions of auditory cortical neurons, including adaptation, spectral interactions, and nonlinear sensitivity to sound level. The models reveal multiple inseparabilities in cortical processing of time lag, frequency, and sound level, and suggest functional mechanisms by which auditory cortical neurons are sensitive to stimulus context. By explicitly modeling these contextual influences, the models are able to predict auditory cortical responses more accurately than are STRF models. In addition, they can explain some forms of stimulus dependence in STRFs that were previously poorly understood. 10.1523/JNEUROSCI.3377-07.2008

Microstructural correlates of infant functional development: example of the visual pathways.

J Dubois — 2008-02-25T15:08:43-00:00

J Neurosci, Vol. 28, No. 8. (20 February 2008), pp. 1943-1948.

The development of cognitive functions during childhood relies on several neuroanatomical maturation processes. Among these processes is myelination of the white matter pathways, which speeds up electrical conduction. Quantitative indices of such structural processes can be obtained in vivo with diffusion tensor imaging (DTI), but their physiological significance remains uncertain. Here, we investigated the microstructural correlates of early functional development by combining DTI and visual event-related potentials (VEPs) in 15 one- to 4-month-old healthy infants. Interindividual variations of the apparent conduction speed, computed from the latency of the first positive VEP wave (P1), were significantly correlated with the infants' age and DTI indices measured in the optic radiations. This demonstrates that fractional anisotropy and transverse diffusivity are structural markers of functionally efficient myelination. Moreover, these indices computed along the optic radiations showed an early wave of maturation in the anterior region, with the posterior region catching up later in development, which suggests two asynchronous fronts of myelination in both the geniculocortical and corticogeniculate fibers. Thus, in addition to microstructural information, DTI provides noninvasive exquisite information on the functional development of the brain in human infants.

Two hierarchically organized neural systems for object information in human visual cortex : Article : Nature Neuroscience

2008-01-22T17:57:37-00:00

Strategic Control of Attention to Objects and Locations

Adam Greenberg — 2008-01-21T15:40:35-00:00

J. Neurosci., Vol. 28, No. 3. (16 January 2008), pp. 564-565.

10.1523/JNEUROSCI.4386-07.2008

Attention effects during visual short-term memory maintenance: protection or prioritization?

M Matsukura — 2008-01-11T19:42:42-00:00

Percept Psychophys, Vol. 69, No. 8. (November 2007), pp. 1422-1434.

Interactions between visual attention and visual short-term memory (VSTM) play a central role in cognitive processing. For example, attention can assist in selectively encoding items into visual memory. Attention appears to be able to influence items already stored in visual memory, as well; cues that appear long after the presentation of an array of objects can affect memory for those objects (Griffin & Nobre, 2003). In five experiments, we distinguished two possible mechanisms for the effects of cues on items currently stored in VSTM. A protection account proposes that attention protects the cued item from becoming degraded during the retention interval. By contrast, aprioritization account suggests that attention increases a cued item's priority during the comparison process that occurs when memory is tested. The results of the experiments were consistent with the first of these possibilities, suggesting that attention can serve to protect VSTM representations while they are being maintained.

Asymmetry of Anticipatory Activity in Visual Cortex Predicts the Locus of Attention and Perception

Chad Sylvester — 2007-12-26T20:53:56-00:00

J. Neurosci., Vol. 27, No. 52. (26 December 2007), pp. 14424-14433.

Humans can use advance information to direct spatial attention before stimulus presentation and respond more accurately to stimuli at the attended location compared with unattended locations. Likewise, spatially directed attention is associated with anticipatory activity in the portion of visual cortex representing the attended location. It is unknown, however, whether and how anticipatory signals predict the locus of spatial attention and perception. Here, we show that prestimulus, preparatory activity is highly correlated across regions representing attended and unattended locations. Comparing activity representing attended versus unattended locations, rather than measuring activity for only one location, dramatically improves the accuracy with which preparatory signals predict the locus of attention, largely by removing this positive correlation common across locations. In V3A, moreover, only the difference in activity between attended and unattended locations predicts whether upcoming visual stimuli will be accurately perceived. These results suggest that the locus of attention is coded in visual cortex by an asymmetry of anticipatory activity between attended and unattended locations and that this asymmetry predicts the accuracy of perception. This coding strategy may bias activity in downstream brain regions to represent the stimulus at the attended location. 10.1523/JNEUROSCI.3759-07.2007

Medial Temporal Lobe Activity Predicts Successful Relational Memory Binding

Deborah Hannula — 2008-01-02T18:42:30-00:00

J. Neurosci., Vol. 28, No. 1. (2 January 2008), pp. 116-124.

Previous neuropsychological findings have implicated medial temporal lobe (MTL) structures in retaining object-location relations over the course of short delays, but MTL effects have not always been reported in neuroimaging investigations with similar short-term memory requirements. Here, we used event-related functional magnetic resonance imaging to test the hypothesis that the hippocampus and related MTL structures support accurate retention of relational memory representations, even across short delays. On every trial, four objects were presented, each in one of nine possible locations of a three-dimensional grid. Participants were to mentally rotate the grid and then maintain the rotated representation in anticipation of a test stimulus: a rendering of the grid, rotated 90degrees from the original viewpoint. The test stimulus was either a "match" display, in which object-location relations were intact, or a "mismatch" display, in which one object occupied a new, previously unfilled location (mismatch position), or two objects had swapped locations (mismatch swap). Encoding phase activation in anterior and posterior regions of the left hippocampus, and in bilateral perirhinal cortex, predicted subsequent accuracy on the short-term memory decision, as did bilateral posterior hippocampal activity after the test stimulus. Notably, activation in these posterior hippocampal regions was also sensitive to the degree to which object-location bindings were preserved in the test stimulus; activation was greatest for match displays, followed by mismatch-position displays, and finally mismatch-swap displays. These results indicate that the hippocampus and related MTL structures contribute to successful encoding and retrieval of relational information in visual short-term memory. 10.1523/JNEUROSCI.3086-07.2008

Universal memory mechanism for familiarity recognition and identification.

V Yakovlev — 2008-01-11T19:00:54-00:00

J Neurosci, Vol. 28, No. 1. (2 January 2008), pp. 239-248.

Macaque monkeys were tested on a delayed-match-to-multiple-sample task, with either a limited set of well trained images (in randomized sequence) or with never-before-seen images. They performed much better with novel images. False positives were mostly limited to catch-trial image repetitions from the preceding trial. This result implies extremely effective one-shot learning, resembling Standing's finding that people detect familiarity for 10,000 once-seen pictures (with 80% accuracy) (Standing, 1973). Familiarity memory may differ essentially from identification, which embeds and generates contextual information. When encountering another person, we can say immediately whether his or her face is familiar. However, it may be difficult for us to identify the same person. To accompany the psychophysical findings, we present a generic neural network model reproducing these behaviors, based on the same conservative Hebbian synaptic plasticity that generates delay activity identification memory. Familiarity becomes the first step toward establishing identification. Adding an inter-trial reset mechanism limits false positives for previous-trial images. The model, unlike previous proposals, relates repetition-recognition with enhanced neural activity, as recently observed experimentally in 92% of differential cells in prefrontal cortex, an area directly involved in familiarity recognition. There may be an essential functional difference between enhanced responses to novel versus to familiar images: The maximal signal from temporal cortex is for novel stimuli, facilitating additional sensory processing of newly acquired stimuli. The maximal signal for familiar stimuli arising in prefrontal cortex facilitates the formation of selective delay activity, as well as additional consolidation of the memory of the image in an upstream cortical module.

The relationship between covert and overt attention in endogenous cuing.

S Van der Stigchel — 2007-10-15T14:07:12-00:00

Percept Psychophys, Vol. 69, No. 5. (July 2007), pp. 719-731.

In a standard Posner paradigm, participants were endogenously cued to attend to a peripheral location in visual space without making eye movements. They responded faster to target letters presented at cued than at uncued locations. On some trials, instead of a manual response, they had to move their eyes to a location in space. Results showed that the eyes deviated away from the validly cued location; when the cue was invalid and attention had to be allocated to the uncued location, eye movements also deviated away, but now from the uncued location. The extent to which the eyes deviated from cued and uncued locations was related to the dynamics of attention allocation. We hypothesized that this deviation was due to the successful inhibition of the attended location. The results imply that the oculomotor system is not only involved during the endogenous direction of covert attention to a cued location, but also when covert attention is directed to an uncued location. It appears that the oculomotor system is activated wherever spatial attention is allocated. The strength of saccade deviation might turn out to be an important measure for the amount of attention allocated to any particular location over time.

Task-dependent costs in processing two simultaneous auditory stimuli.

FJ Gallun — 2007-10-15T14:04:00-00:00

Percept Psychophys, Vol. 69, No. 5. (July 2007), pp. 757-771.

A listener presented with two speech signals must at times sacrifice the processing of one signal in order to understand the other. This study was designed to distinguish costs related to interference from a second signal (selective attention) from costs related to performing two tasks simultaneously (divided attention). Listeners presented with two processed speech-in-noise stimuli, one to each ear, either (1) identified keywords in both or (2) identified keywords in one and detected the presence of speech in the other. Listeners either knew which ear to report in advance (single task) or were cued afterward (partial-report dual task). When the dual task required two identification judgments, performance suffered relative to the single-task condition (as measured by percent correct judgments). Two different tasks (identification for one stimulus and detection for the other) resulted in much smaller reductions in performance when the cue came afterward. We concluded that the degree to which listeners can simultaneously process dichotic speech stimuli seems to depend not only on the amount of interference between the two stimuli, but also on whether there is competition for limited processing resources. We suggest several specific hypotheses as to the structural mechanisms that could constitute these limited resources.

Information persistence in the integration of partial cues for object recognition.

E Greene — 2007-10-15T14:00:39-00:00

Percept Psychophys, Vol. 69, No. 5. (July 2007), pp. 772-784.

A great many studies have shown that the perceptual effects of very brief visual stimuli can persist beyond the duration of the stimulus itself. These effects include sustained perception of the stimulus even though it is no longer present and the integration of information across an interstimulus interval. These two forms of sustained activity can be characterized as visible persistence and information persistence. Iconic memory protocols and a number of discrimination tasks have demonstrated the existence of information persistence that can last up to several hundred milliseconds, but there is little evidence that the cues needed for identification of objects can be transferred across intervals in this range. In the present experiments, a minimal transient discrete cue protocol was used to demonstrate that shape cues, these being provided by subsets of dots that mark the outer boundary of nameable objects, can be integrated over several hundred milliseconds and that the duration is a function of ambient room illumination. The experiments further evaluated whether this information persistence is mediated by visible persistence. Although both perceptual effects have durations that are an inverse function of room illumination, the ability to integrate partial shape cues was not determined by the duration of visible persistence.

Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual Cortex

Jessica Cardin — 2007-09-26T19:26:53-00:00

J. Neurosci., Vol. 27, No. 39. (26 September 2007), pp. 10333-10344.

Although several lines of evidence suggest that stimulus selectivity in somatosensory and visual cortices is critically dependent on unselective inhibition, particularly in the thalamorecipient layer 4, no comprehensive comparison of the responses of excitatory and inhibitory cells has been conducted. Here, we recorded intracellularly from a large population of regular spiking (RS; presumed excitatory) and fast spiking (FS; presumed inhibitory) cells in layers 26 of primary visual cortex. In layer 4, where selectivity for orientation and spatial frequency first emerges, we found no untuned FS cells. Instead, the tuning of the spike output of layer 4 FS cells was significantly but moderately broader than that of RS cells. However, the tuning of the underlying synaptic responses was not different, indicating that the difference in spike-output selectivity resulted from differences in the transformation of synaptic input into firing rate. Layer 4 FS cells exhibited significantly lower input resistance and faster time constants than layer 4 RS cells, leading to larger and faster membrane potential (Vm) fluctuations. FS cell Vm fluctuations were more broadly tuned than those of RS cells and matched spike-output tuning, suggesting that the broader spike tuning of these cells was driven by visually evoked synaptic noise. These differences were not observed outside of layer 4. Thus, cell type-specific differences in stimulus feature selectivity at the first level of cortical sensory processing may arise as a result of distinct biophysical properties that determine the dynamics of synaptic integration. 10.1523/JNEUROSCI.1692-07.2007

Attention Improves Population-Level Frequency Tuning in Human Auditory Cortex

Hidehiko Okamoto — 2007-09-26T21:03:25-00:00

J. Neurosci., Vol. 27, No. 39. (26 September 2007), pp. 10383-10390.

Attention improves auditory performance in noisy environments by either enhancing the processing of task-relevant stimuli ("gain"), suppressing task-irrelevant information ("sharpening"), or both. In the present study, we investigated the effect of focused auditory attention on the population-level frequency tuning in human auditory cortex by means of magnetoencephalography. Using complex stimuli consisting of a test tone superimposed on different band-eliminated noises during active listening or distracted listening conditions, we observed that focused auditory attention caused not only gain, but also sharpening of frequency tuning in human auditory cortex as reflected by the N1m auditory evoked response. This combination of gain and sharpening in the auditory cortex may contribute to better auditory performance during focused auditory attention. 10.1523/JNEUROSCI.2963-07.2007

Off-line processing: reciprocal interactions between declarative and procedural memories.

RM Brown — 2007-10-03T15:20:03-00:00

J Neurosci, Vol. 27, No. 39. (26 September 2007), pp. 10468-10475.

The acquisition of declarative (i.e., facts) and procedural (i.e., skills) memories may be supported by independent systems. This same organization may exist, after memory acquisition, when memories are processed off-line during consolidation. Alternatively, memory consolidation may be supported by interactive systems. This latter interactive organization predicts interference between declarative and procedural memories. Here, we show that procedural consolidation, expressed as an off-line motor skill improvement, can be blocked by declarative learning over wake, but not over a night of sleep. The extent of the blockade on procedural consolidation was correlated to participants' declarative word recall. Similarly, in another experiment, the reciprocal relationship was found: declarative consolidation was blocked by procedural learning over wake, but not over a night of sleep. The decrease in declarative recall was correlated to participants' procedural learning. These results challenge the concept of fixed independent memory systems; instead, they suggest a dynamic relationship, modulated by when consolidation takes place, allowing at times for a reciprocal interaction between memory systems.

Gain Mechanisms for Contextually Guided Visuomotor Transformations

Marina Brozovic — 2007-09-26T19:28:17-00:00

J. Neurosci., Vol. 27, No. 39. (26 September 2007), pp. 10588-10596.

A prevailing question in sensorimotor research is the integration of sensory signals with abstract behavioral rules (contexts) and how this results in decisions about motor actions. We used neural network models to study how context-specific visuomotor remapping may depend on the functional connectivity among multiple layers. Networks were trained to perform different rotational visuomotor associations, depending on the stimulus color (a nonspatial context signal). In network I, the context signal was propagated forward through the network (bottom-up), whereas in network II, it was propagated backwards (top-down). During the presentation of the visual cue stimulus, both networks integrate the context with the sensory information via a mechanism similar to the classic gain field. The recurrence in the networks hidden layers allowed a simulation of the multimodal integration over time. Network I learned to perform the proper visuomotor transformations based on a context-modulated memory of the visual cue in its hidden layer activity. In network II, a brief visual response, which was driven by the sensory input, is quickly replaced by a context-modulated motor-goal representation in the hidden layer. This happens because of a dominant feedback signal from the output layer that first conveys context information, and then, after the disappearance of the visual cue, conveys motor goal information. We also show that the origin of the context information is not necessarily closely tied to the top-down feedback. However, we suggest that the predominance of motor-goal representations found in the parietal cortex during context-specific movement planning might be the consequence of strong top-down feedback originating from within the parietal lobe or from the frontal lobe. 10.1523/JNEUROSCI.2685-07.2007

The serial reaction time task: implicit motor skill learning?

EM Robertson — 2007-09-24T14:05:22-00:00

J Neurosci, Vol. 27, No. 38. (19 September 2007), pp. 10073-10075.

Temporal encoding of movement in motor cortical neurons.

JA Pruszynski — 2007-09-24T14:04:52-00:00

J Neurosci, Vol. 27, No. 38. (19 September 2007), pp. 10076-10077.

Auditory spatial perception dynamically realigns with changing eye position.

B Razavi — 2007-09-24T13:58:55-00:00

J Neurosci, Vol. 27, No. 38. (19 September 2007), pp. 10249-10258.

Audition and vision both form spatial maps of the environment in the brain, and their congruency requires alignment and calibration. Because audition is referenced to the head and vision is referenced to movable eyes, the brain must accurately account for eye position to maintain alignment between the two modalities as well as perceptual space constancy. Changes in eye position are known to variably, but inconsistently, shift sound localization, suggesting subtle shortcomings in the accuracy or use of eye position signals. We systematically and directly quantified sound localization across a broad spatial range and over time after changes in eye position. A sustained fixation task addressed the spatial (steady-state) attributes of eye position-dependent effects on sound localization. Subjects continuously fixated visual reference spots straight ahead (center), to the left (20 degrees), or to the right (20 degrees) of the midline in separate sessions while localizing auditory targets using a laser pointer guided by peripheral vision. An alternating fixation task focused on the temporal (dynamic) aspects of auditory spatial shifts after changes in eye position. Localization proceeded as in sustained fixation, except that eye position alternated between the three fixation references over multiple epochs, each lasting minutes. Auditory space shifted by approximately 40% toward the new eye position and dynamically over several minutes. We propose that this spatial shift reflects an adaptation mechanism for aligning the "straight-ahead" of perceived sensory-motor maps, particularly during early childhood when normal ocular alignment is achieved, but also resolving challenges to normal spatial perception throughout life.

Alteration of Visual Input Results in a Coordinated Reorganization of Multiple Visual Cortex Maps

Brandon Farley — 2007-09-19T18:13:32-00:00

J. Neurosci., Vol. 27, No. 38. (19 September 2007), pp. 10299-10310.

In the adult visual cortex, multiple feature maps exist and have characteristic spatial relationships with one another. The relationships can be reproduced by "dimension-reduction" computational models, suggesting that the principles of continuity and coverage may underlie cortical map organization. However, the mechanisms responsible for establishing these relationships are unknown. We explored whether removing one feature map during development causes a coordinated reorganization of the remaining maps or whether the remaining maps are unaffected. We removed the ocular dominance map by monocular enucleation in newborn ferrets, so that single eye stimulation drove the cortex in a more spatially uniform manner in adult monocular animals compared with normal animals. Maps of orientation, spatial frequency, and retinotopy formed in monocular ferrets, but their structures and spatial relationships differed from those in normal ferrets. The wavelength of the orientation map increased, so that the average orientation gradient across the cortex decreased. The decrease in the orientation gradient in monocular animals was most prominent in the high gradient regions of the spatial frequency map, indicating a coordinated reorganization between these two maps. In monocular animals, the orthogonal relationship between the orientation and spatial frequency maps was preserved, and the orthogonal relationship between the orientation and retinotopic maps became more pronounced. These results were consistent with detailed predictions of a dimension-reduction model of cortical organization. Thus, the number of feature maps in a cortical area influences the relationships between them, and inputs to the cortex have a significant role in generating these relationships. 10.1523/JNEUROSCI.2257-07.2007

Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements.

HC Leung — 2007-09-20T14:05:42-00:00

J Neurosci, Vol. 27, No. 37. (12 September 2007), pp. 9893-9900.

The inferior frontal cortex, particularly the ventrolateral prefrontal cortex (VLPFC) in the right hemisphere, has been implicated to serve as a general inhibitory mechanism in the cognitive control of behavior. Because this notion was primarily based on studies of response inhibition in manual tasks, it has yet to be validated in other response modalities. We conducted a functional magnetic resonance imaging study to examine whether the VLPFC is commonly activated during inhibition of responses by hand and by eye within the same subjects. We used the stop-signal task, a relatively pure measure of response inhibition, as the behavioral paradigm. Results from 12 subjects showed that both the right and the left caudal VLPFC and anterior insula, rostral to the premotor area, are activated during inhibition of both manual and saccadic responses. Within the posterior VLPFC, activations overlapped to a significant extent across the two response modalities, although a weaker functionally differentiation was also found along the dorsoventral axis. Other areas such as medial superior frontal gyrus (pre-supplementary motor area/supplementary eye field), dorsolateral prefrontal cortex, and inferior parietal cortex were also activated during canceling both hand and eye movements. Our findings suggest that a common VLPFC network is involved in response inhibition, although the specific control of the different response modalities may be partially segregated within the lateral prefrontal cortex.

Motor force field learning influences visual processing of target motion.

LE Brown — 2007-09-20T14:00:47-00:00

J Neurosci, Vol. 27, No. 37. (12 September 2007), pp. 9975-9983.

There are reciprocal connections between visual and motor areas of the cerebral cortex. Although recent studies have provided intriguing new insights, in comparison with volume of research on the visual control of movement, relatively little is known about how movement influences vision. The motor system is perfectly suited to learn about environmental forces. Does environmental force information, learned by the motor system, influence visual processing? Here, we show that learning to compensate for a force applied to the hand influenced how participants predicted target motion for interception. Ss trained in one of three constant force fields by making reaching movements while holding a robotic manipulandum. The robot applied forces in a null [null force field (NFF)], leftward [leftward force field (LFF)], or [rightward force field (RFF)] direction. Training was followed immediately with an interception task. The target accelerated from left to right and Ss's task was to stab it. When viewing time was optimal for prediction, the RFF group initiated their responses earlier and hit more targets, and the LFF group initiated their responses later and hit fewer targets, than the NFF group. In follow-up experiments, we show that motor learning is necessary, and we rule out the possibility that explicit force direction information drives how Ss altered their predictions of visual motion. Environmental force information, acquired by motor learning, influenced how the motion of nearby visual targets was predicted.

Effects of Selective Attention on the Electrophysiological Representation of Concurrent Sounds in the Human Auditory Cortex

Aurelie Bidet-Caulet — 2007-08-29T17:39:13-00:00

J. Neurosci., Vol. 27, No. 35. (29 August 2007), pp. 9252-9261.

In noisy environments, we use auditory selective attention to actively ignore distracting sounds and select relevant information, as during a cocktail party to follow one particular conversation. The present electrophysiological study aims at deciphering the spatiotemporal organization of the effect of selective attention on the representation of concurrent sounds in the human auditory cortex. Sound onset asynchrony was manipulated to induce the segregation of two concurrent auditory streams. Each stream consisted of amplitude modulated tones at different carrier and modulation frequencies. Electrophysiological recordings were performed in epileptic patients with pharmacologically resistant partial epilepsy, implanted with depth electrodes in the temporal cortex. Patients were presented with the stimuli while they either performed an auditory distracting task or actively selected one of the two concurrent streams. Selective attention was found to affect steady-state responses in the primary auditory cortex, and transient and sustained evoked responses in secondary auditory areas. The results provide new insights on the neural mechanisms of auditory selective attention: stream selection during sound rivalry would be facilitated not only by enhancing the neural representation of relevant sounds, but also by reducing the representation of irrelevant information in the auditory cortex. Finally, they suggest a specialization of the left hemisphere in the attentional selection of fine-grained acoustic information. 10.1523/JNEUROSCI.1402-07.2007

The representation of complex images in spatial frequency domains of primary visual cortex.

JX Zhang — 2007-09-03T15:46:55-00:00

J Neurosci, Vol. 27, No. 35. (29 August 2007), pp. 9310-9318.

The organization of cat primary visual cortex has been well mapped using simple stimuli such as sinusoidal gratings, revealing superimposed maps of orientation and spatial frequency preferences. However, it is not yet understood how complex images are represented across these maps. In this study, we ask whether a linear filter model can explain how cortical spatial frequency domains are activated by complex images. The model assumes that the response to a stimulus at any point on the cortical surface can be predicted by its individual orientation, spatial frequency, and temporal frequency tuning curves. To test this model, we imaged the pattern of activity within cat area 17 in response to stimuli composed of multiple spatial frequencies. Consistent with the predictions of the model, the stimuli activated low and high spatial frequency domains differently: at low stimulus drift speeds, both domains were strongly activated, but activity fell off in high spatial frequency domains as drift speed increased. To determine whether the filter model quantitatively predicted the activity patterns, we measured the spatiotemporal tuning properties of the functional domains in vivo and calculated expected response amplitudes from the model. The model accurately predicted cortical response patterns for two types of complex stimuli drifting at a variety of speeds. These results suggest that the distributed activity of primary visual cortex can be predicted from cortical maps like those of orientation and SF preference generated using simple, sinusoidal stimuli, and that dynamic visual acuity is degraded at or before the level of area 17.

Differential recruitment of the hippocampus, medial prefrontal cortex, and the human motion complex during path integration in humans.

T Wolbers — 2007-09-04T15:20:45-00:00

J Neurosci, Vol. 27, No. 35. (29 August 2007), pp. 9408-9416.

Path integration, the ability to sense self-motion for keeping track of changes in orientation and position, constitutes a fundamental mechanism of spatial navigation and a keystone for the development of cognitive maps. Whereas animal path integration is predominantly supported by the head-direction, grid, and place cell systems, the neural foundations are not well understood in humans. Here we used functional magnetic resonance imaging and a virtual rendition of a triangle completion paradigm to test whether human path integration recruits a cortical system similar to that of rodents and nonhuman primates. Participants traveled along two legs of a triangle before pointing toward the starting location. In accordance with animal models, stronger right hippocampal activation predicted more accurate updating of the starting location on a trial-by-trial basis. Moreover, between-subjects fluctuations in response consistency were negatively correlated with bilateral hippocampal and medial prefrontal activation, and bilateral recruitment of the human motion complex (hMT+) covaried with individual path integration capability. Given that these effects were absent in a perceptual control task, the present study provides the first evidence that visual path integration is related to the dynamic interplay of self-motion processing in hMT+, higher-level spatial processes in the hippocampus, and spatial working memory in medial prefrontal cortex.

Lateral and vertical attentional biases in normal individuals.

V Drago — 2007-09-04T15:14:09-00:00

Int J Neurosci, Vol. 117, No. 10. (October 2007), pp. 1415-1424.

Background: When normal people attempt to bisect lines they often make their mark to the left of midline (pseudoneglect) and when attempting to bisect radial lines normal people tend to bisect distal to the actual midline. These biases might be related to asymmetrical activation induced by making spatial computations or attention-intentional preferences. The purpose of this study was to learn if in the absence of spatial computations normal subjects would demonstrate a left and upward bias. Methods: Normal subjects (139) were given 8 pegs and asked to place these pegs anywhere on a 2-foot-square board. Results: Overall, the subjects displaced the pegs to the left and upward. Conclusions: The overall left-distal bias observed in this experiment was not induced by spatial computation or misperceptions, but is consistent with the postulate that the right hemisphere is dominant for attention-intention and has a relatively distal bias.

Concurrent task performance enhances low-level visuomotor learning.

RA Roche — 2007-09-04T15:11:23-00:00

Percept Psychophys, Vol. 69, No. 4. (May 2007), pp. 513-522.

Visuomotor association learning involves learning to make a motor response to an arbitrary visual stimulus. This learning is essential for visual search and discrimination performance and is reliant upon a well-defined neural circuit in the brain that includes the prefrontal cortex and the hippocampal formation. In the present study, we investigated the possible role of attentional processes during such learning using dual-task interference. A motor, verbal, or perceptual concurrent task was performed during the learning/training block of a simple visual discrimination task. Contrary to expectation, the dual-task groups showed improved learning and learning-dependent performance compared with untrained control and non-dual-task trained groups. A second experiment revealed that this effect did not appear to be due to increased arousal level; the inclusion of alerting tones during learning did not result in facilitation. These findings suggest that the engagement of attention, but not arousal, during the acquisition of a visuomotor association can facilitate this learning and its expression.

Feature-based attention influences later temporal perception.

F Ono — 2007-09-04T15:06:57-00:00

Percept Psychophys, Vol. 69, No. 4. (May 2007), pp. 544-549.

We investigated the influence of feature-based visual attention on later temporal perception. Although there is ample evidence that space-based attention modulates temporal perception, it is not known whether feature-based attention also serves this function. The present study combined a visual selection task with a temporal interval production task to determine whether feature-based attention interacted with temporal perception. The results indicated that temporal perception of visual stimuli depended on whether the same stimulus had been attended to or ignored in a previous visual selection task. The temporal production of previously ignored stimuli was longer than the temporal production of either previously attended to or novel stimuli. This is the first demonstration of the effect of feature-based attention on later temporal perception. We concluded that temporal perception is affected by previously ignored stimuli.

The role of location and motion information in the tracking and recovery of moving objects.

DE Fencsik — 2007-09-04T15:03:51-00:00

Percept Psychophys, Vol. 69, No. 4. (May 2007), pp. 567-577.

Observers in a multiple object tracking task can track about four to five independently moving targets among several moving distractors, even if all of the stimuli disappear for a 300-msec gap. How observers reacquire targets following such a gap reveals what kind of information they can maintain for targets. Previous research has suggested that participants maintain minimal information about a set of moving objects--namely, just their present spatial locations. We report five new experiments that demonstrate retention of location information for at least four objects, and extrapolated motion information for around two objects.

Deployment of spatial attention to words in central and peripheral vision.

S Ducrot — 2007-09-04T14:56:55-00:00

Percept Psychophys, Vol. 69, No. 4. (May 2007), pp. 578-590.

Four perceptual identification experiments examined the influence of spatial cues on the recognition of words presented in central vision (with fixation on either the first or last letter of the target word) and in peripheral vision (displaced left or right of a central fixation point). Stimulus location had a strong effect on word identification accuracy in both central and peripheral vision, showing a strong right visual field superiority that did not depend on eccentricity. Valid spatial cues improved word identification for peripherally presented targets but were largely ineffective for centrally presented targets. Effects of spatial cuing interacted with visual field effects in Experiment 1, with valid cues reducing the right visual field superiority for peripherally located targets, but this interaction was shown to depend on the type of neutral cue. These results provide further support for the role of attentional factors in visual field asymmetries obtained with targets in peripheral vision but not with centrally presented targets.

Shifting attention into and out of objects: evaluating the processes underlying the object advantage.

JM Brown — 2007-09-04T14:53:15-00:00

Percept Psychophys, Vol. 69, No. 4. (May 2007), pp. 606-618.

Visual cuing studies have been widely used to demonstrate and explore contributions from both object- and location-based attention systems. A common finding has been a response advantage for shifts of attention occurring within an object, relative to shifts of an equal distance between objects. The present study examined this advantage for within-object shifts in terms of engage and disengage operations within the object- and location-based attention systems. The rationale was that shifts of attention between objects require object-based attention to disengage from one object before shifting to another, something that is not required for shifts of attention within an object or away from a location. One- and two-object displays were used to assess object-based contributions related to disengaging and engaging attention within, between, into, and out of objects. The results suggest that the "object advantage" commonly found in visual cuing experiments in which shifts of attention are required is primarily due to disengage operations associated with object-based attention.

Typicality effects in face and object perception: further evidence for the attractor field model.

JW Tanaka — 2007-09-04T14:49:54-00:00

Percept Psychophys, Vol. 69, No. 4. (May 2007), pp. 619-627.

In a previous study, it was shown that a 50/50 morph of a typical and an atypical parent face was perceived to be more similar to the atypical parent face than to the typical parent face (Tanaka, Giles, Kremen, & Simon, 1998). Experiments 1 and 2 examine face typicality effects in a same/different discrimination task in which typical or atypical faces and their 80%, 70%, 60%, and 50% morphs were presented sequentially (Experiment 1) or simultaneously (Experiment 2). The main finding was that in both modes of presentation, atypical morphs were more poorly discriminated than their corresponding typical morphs. In Experiment 3, typicality effects were extended to the perception of nonface objects; in this instance, it was found that 50/50 morphs of birds and cars were judged to be more similar to their atypical parents than to their typical parents. These results are consistent with an attractor field model, in which it is proposed that the perception of a face or object stimulus depends not only on its fit to an underlying representation, but also on the representation's location in the similarity space.

Virtual environment navigation tasks and the assessment of cognitive deficits in individuals with brain injury.

Sharon A Livingstone — 2007-09-01T14:54:03-00:00

Behav Brain Res (17 July 2007)

Navigation in real environments is often impaired by traumatic brain injury (TBI). These deficits in wayfinding appear to be due to disruption of cognitive processes underlying navigation and may in turn be due to damage to the hippocampus and frontal lobes. These wayfinding problems after TBI were investigated using a virtual simulation of a Morris Water Maze (MWM), a standard test of hippocampal function in laboratory animals. The virtual environment consisted of a large virtual arena in a very large virtual room whose walls provided views of a naturalistic landscape. Eleven community-dwelling TBI survivors and 12 comparison participants, matched for gender, age and education were tested to see if they could find a location in the arena marked by one of the following: (a) a visible platform, (b) a single proximal object, (c) a single proximal object among seven other distracter objects, or (d) distal features inside and outside the room. The proximal objects allowed participants to use egocentric (body-centered) navigational strategies that rely on relatively simple stimulus-response associations. The absence of proximal cues forced the participants to rely on distal features of the environment (room walls, landscape elements) and tested their ability to use allocentric (world-based) navigational strategies requiring cognitive mapping. Results indicated that the navigation of TBI survivors was not impaired when the proximal cues were present but was impaired when proximal cues were absent. These results provide more evidence that the navigational deficit after TBI is due to an inability to form, remember or use cognitive maps.