Sat, 26 Jul 2008 07:31:58 BST CiteULike: lechristophe's virus_entry http://www.citeulike.org/user/lechristophe/tag/virus_entry CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/lechristophe/article/2718925 <i>Science, Vol. 320, No. 5875. (25 April 2008), pp. 531-535.</i><br /><br />Viruses employ many different strategies to enter host cells. Vaccinia virus, a prototype poxvirus, enters cells in a pH-dependent fashion. Live cell imaging showed that fluorescent virus particles associated with and moved along filopodia to the cell body, where they were internalized after inducing the extrusion of large transient membrane blebs. p21-activated kinase 1 (PAK1) was activated by the virus, and the endocytic process had the general characteristics of macropinocytosis. The induction of blebs, the endocytic event, and infection were all critically dependent on the presence of exposed phosphatidylserine in the viral membrane, which suggests that vaccinia virus uses apoptotic mimicry to enter cells. 10.1126/science.1155164 Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells Jason Mercer Ari Helenius doi:10.1126/science.1155164 Science, Vol. 320, No. 5875. (25 April 2008), pp. 531-535. 2008-04-25T16:18:21-00:00 2008 Science 320 5875 531 535 cell_culture endocytosis virus_entry