Wed, 20 Aug 2008 21:17:41 BST CiteULike: lisa1's Gout http://www.citeulike.org/user/lisa1/author/Gout CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/lisa1/article/2597355 <i>Nature, Vol. 370, No. 6490. (18 August 1994), pp. 527-532.</i><br /><br />Ras (p21ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras mutant N17 inhibits growth factor induced production of 3' phosphorylated phosphoinositides in PC12 cells, and transfection of Ras, but not Raf, into COS cells results in a large elevation in the level of these lipids. Therefore Ras can probably regulate phosphatidylinositol-3-OH kinase, providing a point of divergence in signalling pathways downstream of Ras. Phosphatidylinositol-3-OH kinase as a direct target of Ras. P Rodriguez-Viciana PH Warne R Dhand B Vanhaesebroeck I Gout MJ Fry MD Waterfield J Downward doi:10.1038/370527a0 Nature, Vol. 370, No. 6490. (18 August 1994), pp. 527-532. 2008-03-26T15:05:17-00:00 1994 Nature 0028-0836 370 6490 527 532 h pi3k ras