Thu, 21 Aug 2008 05:33:07 BST CiteULike: omalbam's Macmullen http://www.citeulike.org/user/omalbam/author/Macmullen CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/omalbam/article/2223120 <i>J Clin Endocrinol Metab, Vol. 92, No. 12. (1 December 2007), pp. 4706-4711.</i><br /><br />Objectives: Focal lesions in infants with congenital hyperinsulinism (HI) represent areas of adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation due to embryonic loss of heterozygosity for the maternal 11p region. This study evaluated the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]DOPA) positron emission tomography (PET) scans in diagnosing focal vs. diffuse disease and identifying the location of focal lesions. Design: A total of 50 infants with HI unresponsive to medical therapy were studied. Patients were injected iv with [18F]DOPA, and PET scans were obtained for 5060 min. Images were coregistered with abdominal computed tomography scans. PET scan interpretations were compared with histological diagnoses. Results: The diagnosis of focal or diffuse HI was correct in 44 of the 50 cases (88%). [18F]DOPA PET identified focal areas of high uptake of radiopharmaceutical in 18 of 24 patients with focal disease. The locations of these lesions matched the areas of increased [18F]DOPA uptake on the PET scans in all of the cases. PET scan correctly located five lesions that could not be visualized at surgery. The positive predictive value of [18F]DOPA in diagnosing focal adenomatosis was 100%, and the negative predictive value was 81%. Conclusions: [18F]DOPA PET scans correctly diagnosed 75% of focal cases and were 100% accurate in identifying the location of the lesion. These results suggest that [18F]DOPA PET imaging provides a useful guide to surgical resection of focal adenomatosis and should be considered as a guide to surgery in all infants with congenital HI who have medically uncontrollable disease. 10.1210/jc.2007-1637 Accuracy of [18F]Fluorodopa Positron Emission Tomography for Diagnosing and Localizing Focal Congenital Hyperinsulinism Olga Hardy Miguel Hernandez-Pampaloni Janet Saffer Joshua Scheuermann Linda Ernst Richard Freifelder Hongming Zhuang Courtney Macmullen Susan Becker Scott Adzick Chaitanya Divgi Abass Alavi Charles Stanley doi:10.1210/jc.2007-1637 J Clin Endocrinol Metab, Vol. 92, No. 12. (1 December 2007), pp. 4706-4711. 2008-01-12T18:37:49-00:00 2007 J Clin Endocrinol Metab 92 12 4706 4711 diagnosis hypoglycemia pet