Sat, 26 Jul 2008 07:55:26 BST CiteULike: omalbam's Roix http://www.citeulike.org/user/omalbam/author/Roix CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/omalbam/article/1281649 <i>Science (26 April 2007)</i><br /><br />New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single nucleotide polymorphisms (SNPs) in 1,464 patients with T2D and 1,467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D) we identify and confirm three loci associated with T2D -- in a non-coding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 -- and replicate associations near HHEX and in SLC30A8 found by a recent whole genome association study. We identify and confirm association of a SNP in an intron of glucokinase regulatory protein with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues into the pathogenesis of common diseases. Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels. Richa Saxena Benjamin F Voight Valeriya Lyssenko Noel P Burtt Paul I W de Bakker Hong Chen Jeffrey J Roix Sekar Kathiresan Joel N Hirschhorn Mark J Daly Thomas E Hughes Leif Groop David Altshuler Peter Almgren Jose C Florez Joanne Meyer Kristin Ardlie Kristina Bengtsson Bo Isomaa Guillaume Lettre Ulf Lindblad Helen N Lyon Olle Melander Christopher Newton-Cheh Peter Nilsson Marju Orho-Melander Lennart Råstam Elizabeth K Speliotes Marja-Riitta Taskinen Tiinamaija Tuomi Candace Guiducci Anna Berglund Joyce Carlson Lauren Gianniny Rachel Hackett Liselott Hall Johan Holmkvist Esa Laurila Marketa Sjögren Maria Sterner Aarti Surti Margareta Svensson Malin Svensson Ryan Tewhey Brendan Blumenstiel Melissa Parkin Matthew Defelice Rachel Barry Wendy Brodeur Jody Camarata Nancy Chia Mary Fava John Gibbons Bob Handsaker Claire Healy Kieu Nguyen Casey Gates Carrie Sougnez Diane Gage Marcia Nizzari Stacey B Gabriel Gung-Wei Chirn Qicheng Ma Hemang Parikh Delwood Richardson Darrell Ricke Shaun Purcell doi:10.1126/science.1142358 Science (26 April 2007) 2007-05-07T08:53:58-00:00 2007 Science 1095-9203 diabetes diagnosis gwa molecular